Abstract
Very often, porosity is the main factor taken into account during the design and synthesis of a material. Many applications can be directly correlated to the porosity of a given material, in uses such as catalysts, absorbents, drug carriers, combustible production, waste management, micro-electronics, medical diagnosis, among others. Three main characteristics describe the catalytic properties of a pore: it allows specific interactions, can be chemically and physically built from scratch to guarantee the best interaction with the target molecule, and its presence exponentially increases the available surface area. In the current chapter, we will focus on porosity in soft materials designed for biomedical applications, specifically hydrogels, giving an overview of their physicochemical behavior and the role of porosity in biomaterial development and characterization.
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References
Smith L (2017) Chapter twelve – Historical perspectives on water purification A2. In: Ahuja S (ed) Chemistry and water. Elsevier, Amsterdam, pp 421–468
Liu PS, Chen GF (2014) Chapter eight – Applications of polymer foams. In: Porous materials. Butterworth-Heinemann, Boston, pp 383–410
Zdravkov BD et al (2007) Pore classification in the characterization of porous materials: a perspective. Cent Eur J Chem 5(2):385–395
Kodikara J, Barbour S, Fredlund D (1999) Changes in clay structure and behaviour due to wetting and drying. In: Proceedings 8th Australia New Zealand conference on geomechanics: consolidating knowledge. Australian Geomechanics Society. Barton, ACT
Kaneko K (1994) Determination of pore size and pore size distribution. J Membr Sci 96(1): 59–89
Rouquerol J et al (1994) Recommendations for the characterization of porous solids (Technical report). Pure Appl Chem 66(8):1739–1758
Loucks RG et al (2012) Spectrum of pore types and networks in mudrocks and a descriptive classification for matrix-related mudrock pores. AAPG Bull 96(6):1071–1098
Champoux Y, Allard JF (1991) Dynamic tortuosity and bulk modulus in air-saturated porous media. J Appl Phys 70(4):1975–1979
Van Keulen J (1973) Density of porous solids. Mater Constr 6(3):181–183
Sarkisov L (2012) Accessible surface area of porous materials: understanding theoretical limits. Adv Mater 24(23):3130–3133
He T et al (2014) Bio-template mediated in situ phosphate transfer to hierarchically porous TiO2 with localized phosphate distribution and enhanced photoactivities. J Phys Chem C 118(9):4607–4617
Rodriguez-Albelo LM et al (2017) Selective sulfur dioxide adsorption on crystal defect sites on an isoreticular metal organic framework series. Nat Commun 8:1–10
Alaaeddin A et al (2015) Rapid removal of organic micropollutants from water by a porous β-cyclodextrin polymer. Nature 529:190–194
Wang CF, Chen LT (2017) Preparation of superwetting porous materials for ultrafast separation of water-in-oil emulsions. Langmuir 33(8):1969–1973
Thommes M (2010) Physical adsorption characterization of nanoporous materials. Chem Ing Tech 82(7):1059–1073
Vanson J-M et al (2015) Unexpected coupling between flow and adsorption in porous media. Soft Matter 11(30):6125–6133
Lu M et al (2016) Chemisorption mechanism of DNA on mg/Fe layered double hydroxide nanoparticles: insights into engineering effective SiRNA delivery systems. Langmuir 32(11): 2659–2667
McCusker LB, Liebau F, Engelhardt G (2003) Nomenclature of structural and compositional characteristics of ordered microporous and mesoporous materials with inorganic hosts:(IUPAC recommendations 2001): (IUPAC recommendations 2001). Microporous Mesoporous Mater 58(1):3–13
Weisz PB (1995) Molecular-diffusion in microporous materials-formalisms and mechanisms. Ind Eng Chem Res 34(8):2692–2699
Vattipalli V et al (2016) Long walks in hierarchical porous materials due to combined surface and configurational diffusion. Chem Mater 28(21):7852–7863
Reinecke SA, Sleep BE (2002) Knudsen diffusion, gas permeability, and water content in an unconsolidated porous medium. Water Resour Res 38(12):1280–1296
Vincent O, Marguet B, Stroock AD (2017) Imbibition triggered by capillary condensation in Nanopores. Langmuir 33(7):1655–1661
Espanol M et al (2016) Impact of porosity and electrolyte composition on the surface charge of hydroxyapatite biomaterials. ACS Appl Mater Interfaces 8(1):908–917
Hao GP et al (2016) Design of Hierarchically Porous Carbons with interlinked hydrophilic and hydrophobic surface and their capacitive behavior. Chem Mater 28(23):8715–8725
Li J et al (2013) Hydrophobic liquid-infused porous polymer surfaces for antibacterial applications. ACS Appl Mater Interfaces 5(14):6704–6711
Odian GG, Odian GG (2004) Principles of polymerization. Wiley, Hoboken
Robert O. Ebewele. Thermal transitions in polymers (2000) In: Polymer science and technology. CRC Press, Boca Raton
Kurihara S (2004) Fast responsive liquid crystalline polymer systems. In: Reflexive polymers and hydrogels. CRC Press, Boca Raton
Koetting MC et al (2015) Stimulus-responsive hydrogels: theory, modern advances, and applications. Proc Mater Sci 93:1–49
Lee KY, Yuk SH (2007) Polymeric protein delivery systems. Prog Polym Sci 32(7):669–697
Schmaljohann D (2006) Thermo- and pH-responsive polymers in drug delivery. Adv Drug Deliv Rev 58(15):1655–1670
Langer R, Peppas NA (2003) Advances in biomaterials, drug delivery, and bionanotechnology. AICHE J 49(12):2990–3006
Kim B, La Flamme K, Peppas NA (2003) Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery. J Appl Polym Sci 89(6):1606–1613
van Der Sman RGM (2015) Biopolymer gel swelling analysed with scaling laws and Flory-Rehner theory. Food Hydrocoll 48:94–101
Bajpai AK et al (2008) Responsive polymers in controlled drug delivery. Prog Polym Sci 33(11):1088–1118
Vrentas JS, Vrentas CM (2003) Steady viscoelastic diffusion. J Appl Polym Sci 88(14): 3256–3263
Amsden B (1998) Solute diffusion within hydrogels. Mechanisms and models. Macromolecules 31(23):8382–8395
Ganji F, Vasheghani-Farahani S, Vasheghani-Farahani E (2010) Theoretical description of hydrogel swelling: a review. Iranian Polym J 19(5):375–398
Cukier RI (1984) Diffusion of brownian spheres in semidilute polymer-solutions. Macromolecules 17(2):252–255
Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deliv Rev 64:18–23
Peppas NA, Khare AR (1993) Preparation, structure and diffusional behavior of hydrogels in controlled release. Adv Drug Deliv Rev 11(1):1–35
Fernandez-Nieves A et al (2000) Charge controlled swelling of microgel particles. Macromolecules 33(6):2114–2118
Hoare TR, Kohane DS (2008) Hydrogels in drug delivery: progress and challenges. Polymer 49(8):1993–2007
Brannon-Peppas L, Peppas NA (1991) Equilibrium swelling behavior of pH-sensitive hydrogels. Chem Eng Sci 46(3):715–722
Li H et al (2005) Modeling and simulation of the swelling behavior of pH-stimulus-responsive hydrogels. Biomacromolecules 6(1):109–120
Ricka J, Tanaka T (1984) Swelling of ionic gels-quantitative performance of the Donnan theory. Macromolecules 17(12):2916–2921
Kurnia JC, Birgersson E, Mujumdar AS (2011) Analysis of a model for pH-sensitive hydrogels. Polymer 53(2):613–622
Chai Q, Jiao Y, Yu X (2017) Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. Gels 3(1):6–21
Oyen ML (2014) Mechanical characterisation of hydrogel materials. Int Mater Rev 59(1): 44–59
Anseth KS, Bowman CN, Brannon-Peppas L (1996) Mechanical properties of hydrogels and their experimental determination. Biomaterials 17(17):1647–1657
Rajinder Pal, Dynamic viscoelastic behavior of composites (2006) In: Rheology of particulate dispersions and composites. CRC Press, Boca Raton, pp 355–372
Deligkaris K et al (2010) Hydrogel-based devices for biomedical applications. Sens Actuators B 147(2):765–774
Hamidi M, Azadi A, Rafiei P (2008) Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev 60(15):1638–1649
Ullah F et al (2015) Classification, processing and application of hydrogels: a review. Mater Sci Eng C Mater 57:414–433
Zhai M et al (2002) Syntheses of PVA/starch grafted hydrogels by irradiation. Carbohydr Polym 50(3):295–303
Pescosolido L et al (2011) In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications. Acta Biomater 7(4):1627–1633
Bajpai AK, Bajpai J, Shukla S (2002) Water sorption through a semi-interpenetrating polymer network (IPN) with hydrophilic and hydrophobic chains. React Funct Polym 50(1):9–21
Haque MA, Kurokawa T, Gong JP (2012) Super tough double network hydrogels and their application as biomaterials. Polymer 53(9):1805–1822
Zhou C, Wu Q (2011) A novel polyacrylamide nanocomposite hydrogel reinforced with natural chitosan nanofibers. Colloid Surf B 84(1):155–162
Zain NAM, Suhaimi MS, Idris A (2011) Development and modification of PVA– alginate as a suitable immobilization matrix. Process Biochem 46(11):2122–2129
Martínez-Gómez F et al (2017) In vitro release of metformin hydrochloride from sodium alginate/polyvinyl alcohol hydrogels. Carbohydr Polym 155:182–191
Martínez-Gómez F et al (2015) Preparation and swelling properties of homopolymeric alginic acid fractions/poly(N-isopropyl acrylamide) graft copolymers. J Appl Polym Sci 132(32): 42398–42408
Brunel F, El Gueddari NE, Moerschbacher BM (2013) Complexation of copper(II) with chitosan nanogels: toward control of microbial growth. Carbohydr Polym 92(2):1348–1356
Yadav M, Rhee KY, Park SJ (2014) Synthesis and characterization of graphene oxide/carboxymethylcellulose/alginate composite blend films. Carbohydr Polym 110:18–25
Li H et al (2017) Surface enhanced Raman scattering properties of dynamically tunable Nanogaps between au nanoparticles self-assembled on hydrogel microspheres controlled by pH. J Colloid Interface Sci 505:467–475
Dong X et al (2016) Self-assembly of monodisperse composite microgels with bimetallic nanorods as core and PNIPAM as shell into close-packed monolayers and SERS efficiency. Mater Des 104:303–311
Dumitriu RP, Mitchell GR, Vasile C (2011) Multi-responsive hydrogels based on N-isopropylacrylamide and sodium alginate. Polym Int 60(2):222–233
Agrahari V et al (2017) Real-time analysis of tenofovir release kinetics using quantitative phosphorus (31P) nuclear magnetic resonance spectroscopy. J Pharm Sci 106:3005. In Press
Sallouh M et al (2015) 1H HR-MAS NMR spectroscopy as a simple tool to characterize peptide – functionalized hydrogels as a function of cross linker density. Polymer 56:141–146
Medronho B et al (2017) From a new cellulose solvent to the cyclodextrin induced formation of hydrogels. Colloid Surf A 532:548. In Press
Grant SC et al (2005) Alginate assessment by NMR microscopy. J Mater Sci Mater Med 16(6):511–514
Hills BP et al (2000) NMR studies of calcium induced alginate gelation. Part II. The internal bead structure. Magn Reson Chem 38(9):719–728
Chu KC, Rutt BK (1997) Polyvinyl alcohol cryogel: an ideal phantom material for MR studies of arterial flow and elasticity. Magn Reson Med 37(2):314–319
de Celis Alonso B et al (2010) NMR relaxometry and rheology of ionic and acid alginate gels. Carbohydr Polym 82(3):663–669
Colsenet R, Mariette F, Cambert M (2005) NMR relaxation and water self-diffusion studies in whey protein solutions and gels. J Agric Food Chem 53(17):6784–6790
Taglienti A, Sequi P, Valentini M (2009) Kinetics of drug release from a hyaluronan-steroid conjugate investigated by NMR spectroscopy. Carbohydr Res 344(2):245–249
Zhang C et al (2016) Hierarchical porous structures in cellulose: NMR relaxometry approach. Polymer 98:237–243
Iijima M et al (2007) AFM studies on gelation mechanism of xanthan gum hydrogels. Carbohydr Polym 68(4):701–707
Pramanick AK et al (2011) Topographical heterogeneity in transparent PVA hydrogels studied by AFM. Mater Sci Eng C 32(2):222–227
Vulpe R et al (2016) Crosslinked hydrogels based on biological macromolecules with potential use in skin tissue engineering. Int J Biol Macromol 84:174–181
Kulkarni RV et al (2010) Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin. Int J Biol Macromol 47(4):520–527
Zhang Y-T et al (2017) Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models. Int J Pharm 528(1–2):100–106
Rasoulzadeh M, Namazi H (2017) Carboxymethyl cellulose/graphene oxide bio-nanocomposite hydrogel beads as anticancer drug carrier agent. Carbohyd Polym 168: 320–326
Zhang XZ et al (2001) Preparation and characterization of fast response macroporous poly(N-isopropylacrylamide) hydrogels. Langmuir 17(20):6094–6099
Zhang J-T, Bhat R, Jandt KD (2009) Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties. Acta Biomater 5(1):488–497
Dumitriu RP, Mitchell GR, Vasile C (2011) Rheological and thermal behaviour of poly(N-isopropylacrylamide)/alginate smart polymeric networks. Polym Int 60(9):1398–1407
Işıklan N, Küçükbalcı G (2012) Microwave-induced synthesis of alginate-graft-poly(N-isopropylacrylamide) and drug release properties of dual pH- and temperature-responsive beads. Eur J Pharm Biopharm 82(2):316–331
Cheaburu CN et al (2013) Thermoresponsive sodium alginate-g-poly(N-isopropylacrylamide) copolymers III. Solution properties. J Appl Polym Sci 127(5):3340–3348
Editorial Nature Materials (2009) Boom time for biomaterials. Nat Mater 8(6):439–439
Caló E, Khutoryanskiy VV (2015) Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J 65:252–267
Wichterle O, Lim D (1960) Hydrophilic gels for biological use. Nature 185(4706):117–118
Liu W et al (2008) Recombinant human collagen for tissue engineered corneal substitutes. Biomaterials 29(9):1147–1158
Alarcon EI et al (2016) Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine. Nanoscale 8(12): 6484–6489
Lloyd AW, Faragher RG, Denyer SP (2001) Ocular biomaterials and implants. Biomaterials 22(8):769–785
am Ende MT, Mikos AG (1997) Diffusion-controlled delivery of proteins from hydrogels and other hydrophilic systems. Pharm Biotechnol 10:139–165
Lim HL et al (2014) Smart hydrogels as functional biomimetic systems. Biomater Sci 2(5): 603–618
Schwalfenberg GK (2012) The alkaline diet: is there evidence that an alkaline pH diet benefits health? J Environ Public Health 2012:1–7
Gupta P, Vermani K, Garg S (2002) Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today 7(10):569–579
Qi H et al (2017) Dual responsive zein hydrogel membrane with selective protein adsorption and sustained release property. Mater Sci Eng C Mater 70:347–356
Ma G et al (2017) Development of ionic strength/pH/enzyme triple-responsive zwitterionic hydrogel of the mixed l – glutamic acid and l – lysine polypeptide for site-specific drug delivery. J Mater Chem B 5(5):935–943
Gutowska AB, Han Y, Feijen J, Kim SW (1992) Heparin release from thermosensitive hydrogels. J Control Release 22:95–104
Jeong B et al (1997) Biodegradable block copolymers as injectable drug-delivery systems. Nature 388(6645):860–862
Dong L, Jiang H (2007) Autonomous microfluidics with stimuli-responsive hydrogels. Soft Matter 3(10):1223–1230
Holtz JH, Asher SA (1997) Polymerized colloidal crystal hydrogel films as intelligent chemical sensing materials. Nature 389(6653):829–832
Brown LR et al (1996) Characterization of glucose-mediated insulin release from implantable polymers. J Pharm Sci 85(12):1341–1345
Heller J et al (1978) Controlled drug release by polymer dissolution. I. Partial esters of maleic anhydride copolymers – properties and theory. J Appl Polym Sci 22(7):1991–2009
D’Emanuele A, Staniforth JN (1991) An electrically modulated drug delivery device: I. Pharm Res 8(7):913–918
Baroli B (2007) Hydrogels for tissue engineering and delivery of tissue-inducing substances. J Pharm Sci 96(9):2197–2223
Nicodemus GD, Bryant SJ (2008) Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng Part B Rev 14(2):149–165
Peretti GM et al (2006) Tissue engineered cartilage integration to live and devitalized cartilage: a study by reflectance mode confocal microscopy and standard histology. Connect Tissue Res 47(4):190–199
Langer R, Tirrell DA (2004) Designing materials for biology and medicine. Nature 428(6982): 487–492
Caliari SR, Burdick JA (2016) A practical guide to hydrogels for cell culture. Nat Methods 13(5):405–414
El-Sherbiny IM, Yacoub MH (2013) Hydrogel scaffolds for tissue engineering: progress and challenges. Glob Cardiol Sci Pract 2013(3):316–342
Chen A, Davis BH (1999) UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells. J Biol Chem 274(1):158–164
Yang S et al (2001) The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 7(6):679–689
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Ahumada, M., Jacques, E., Calderon, C., Martínez-Gómez, F. (2019). Porosity in Biomaterials: A Key Factor in the Development of Applied Materials in Biomedicine. In: Martínez, L., Kharissova, O., Kharisov, B. (eds) Handbook of Ecomaterials. Springer, Cham. https://doi.org/10.1007/978-3-319-68255-6_162
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DOI: https://doi.org/10.1007/978-3-319-68255-6_162
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