Synonyms
Historical Background
The activity of G-protein-coupled receptor kinase 1 (GRK1) was first observed in the light-dependent phosphorylation of rhodopsin in rod outer segment (ROS). As GRK1 was unstable during biochemical manipulations, isolating it in sufficient quantity and quality was proven to be difficult over a period of 30 years (Maeda et al. 2003). The GRK1 gene was cloned in the early 1990s (Lorenz et al. 1991), and many findings regarding its roles in phototransduction recovery, light and dark adaptation, and stationary night blindness of human Oguchi disease took place in the following decade (Chen et al. 1999; Lyubarsky et al. 2000; Khani et al. 1998; Cideciyan et al. 1998). GRK1 is posttranslationally modified by isoprenylation and phosphorylation, and its catalytic activity can be regulated by other proteins such as recoverin (Chen et al. 1995) and protein kinase A (Horner et al. 2005). It is...
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Ames JB, Levay K, et al. Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin. J Biol Chem. 2006;281(48):37237–45.
Azam M, Collin RW, et al. A novel mutation in GRK1 causes Oguchi disease in a consanguineous Pakistani family. Mol Vis. 2009;15:1788–93.
Boguth CA, Singh P, et al. Molecular basis for activation of G protein-coupled receptor kinases. EMBO J. 2009;29(19):3249–59.
Carr RE, Gouras P. Oguchi’s disease. Arch Ophthalmol. 1965;73:646–56.
Chen CK. The vertebrate phototransduction cascade: amplification and termination mechanisms. Rev Physiol Biochem Pharmacol. 2005;154:101–21.
Chen CK, Inglese J, et al. Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. J Biol Chem. 1995;270(30):18060–6.
Chen CK, Burns ME, et al. Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci USA. 1999;96(7):3718–22.
Chen CK, Zhang K, et al. Characterization of human GRK7 as a potential cone opsin kinase. Mol Vis. 2001;7:305–13.
Chen CK, Woodruff ML, et al. Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods. J Neurosci. 2010;30(4):1213–20.
Choi S, Hao W, et al. Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas. Proc Natl Acad Sci USA. 2001;98(23):13096–101.
Cideciyan AV, Zhao X, et al. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci USA. 1998;95(1):328–33.
Dorn 2nd GW. GRK mythology: G-protein receptor kinases in cardiovascular disease. J Mol Med. 2009;87(5):455–63.
Fan J, Sakurai K, et al. Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J Neurosci. 2010;30(7):2496–503.
Hao W, Wenzel A, et al. Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat Genet. 2002;32(2):254–60.
Hashimoto H, Kishi S. Shortening of the rod outer segment in Oguchi disease. Graefes Arch Clin Exp Ophthalmol. 2009 Nov;247(11):1561–3.
Hayashi T, Gekka T, et al. A novel homozygous GRK1 mutation (P391H) in 2 siblings with Oguchi disease with markedly reduced cone responses. Ophthalmology. 2007;114(1):134–41.
Higgins MK, Oprian DD, et al. Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase. J Biol Chem. 2006;281(28):19426–32.
Horner TJ, Osawa S, et al. Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. J Biol Chem. 2005;280(31):28241–50.
Inglese J, Glickman JF, et al. Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. J Biol Chem. 1992;267(3):1422–5.
Khani SC, Nielsen L, et al. Biochemical evidence for pathogenicity of rhodopsin kinase mutations correlated with the oguchi form of congenital stationary night blindness. Proc Natl Acad Sci USA. 1998;95(6):2824–7.
Krishnan J, Lee G, et al. Characterization of phototransduction gene knockouts revealed important signaling networks in the light-induced retinal degeneration. J Biomed Biotechnol. 2008;2008:327468.
Krispel CM, Chen D, et al. RGS expression rate-limits recovery of rod photoresponses. Neuron. 2006;51(4):409–16.
Lorenz W, Inglese J, et al. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci USA. 1991;88(19):8715–9.
Lyubarsky AL, Chen C, et al. Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci. 2000;20(6):2209–17.
Maeda T, Imanishi Y, et al. Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res. 2003;22(4):417–34.
Makino CL, Dodd RL, et al. Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. J Gen Physiol. 2004;123(6):729–41.
McTaggart SJ. Isoprenylated proteins. Cell Mol Life Sci. 2006;63(3):255–67.
Ribas C, Penela P, et al. The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta. 2007;1768(4):913–22.
Singh P, Wang B, et al. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem. 2008;283(20):14053–62.
Strissel KJ, Lishko PV, et al. Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. J Biol Chem. 2005;280(32):29250–5.
Weiss ER, Raman D, et al. The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. Mol Vis. 1998;4:27.
Weiss ER, Ducceschi MH, et al. Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. J Neurosci. 2001;21(23):9175–84.
Whitcomb T, Sakurai K, et al. Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability. Invest Ophthalmol Vis Sci. 2010;51(3):1728–37.
Yamamoto S, Sippel KC, et al. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet. 1997;15(2):175–8.
Zhang Q, Zulfiqar F, et al. A variant form of Oguchi disease mapped to 13q34 associated with partial deletion of GRK1 gene. Mol Vis. 2005;11:977–85.
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Chen, F.S., Chen, CK.(. (2018). G-Protein-Coupled Receptor Kinase 1 (GRK1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_589
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DOI: https://doi.org/10.1007/978-3-319-67199-4_589
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