Background
Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive sphingolipid metabolite. Sphingolipids are essential structural constituents of the plasma membrane of all eukaryotic organisms and are also produced by some bacteria. In response to a wide range of stressful stimuli, membrane sphingomyelin and to lesser extent other complex sphingolipids are rapidly metabolized to the bioactive sphingolipid intermediate, ceramide and subsequently to sphingosine (Hannun and Obeid 2008). Phosphorylation of sphingosine by two sphingosine kinases (SphKs) results in the formation of S1P. It has emerged as a potent signaling molecule that regulates diverse cellular processes including cell proliferation, survival, differentiation, and migration (Spiegel and Milstien 2003). S1P plays a critical role in several physiological processes including lymphocyte...
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Kumar, A., Saba, J.D. (2018). Sphingosine-1-Phosphate. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_452
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DOI: https://doi.org/10.1007/978-3-319-67199-4_452
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