This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bertaso F, Roussignol G, Worley P, Bockaert J, Fagni L, Ango F. Homer 1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. PLoS ONE. 2010;5:e9755.
Cao L, Tian Y, Jiang Y, Zhang GJ, Lei H, Di ZL. Down-regulation of Homer 1b/c protects against chemically induced seizures through inhibition of mTOR signaling. Cell Physiol Biochem. 2015;35:1633–42. PMID: 25824461.
Duncan RS, Hwang SY, Koulen P. Effects of Vesl/Homer proteins on intracellular signaling. Exp Biol Med Maywood. 2005;230:527–35.
Duncan RS, Goad DL, Grillo MA, Kaja S, Payne AJ, Koulen P. Control of intracellular calcium signaling as a neuroprotective strategy. Molecules. 2010;15(3):1168–95.
Gutierrez-Mecinas M, Kuehn ED, Abraira VE, Polgár E, Watanabe M, Todd AJ. Immunostaining for Homer reveals the majority of excitatory synapses in laminae I–III of the mouse spinal dorsal horn. Neuroscience. 2016;329:171–81. PMID: 27185486.
Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM. Metabotropic glutamate. receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease. Brain. 2016;139:526–46. PMID: 26667279.
Hayashi MK, Ames HM, Hayashi Y. Tetrameric hub structure of postsynaptic scaffolding protein homer. J Neurosci. 2006;26:8492–501.
Hayashi MK, Tang C, Verpelli C, Narayanan R, Stearns MH, Xu RM, et al. The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell. 2009;137:159–71.
Hwang SY, Wei J, Westhoff JH, Duncan RS, Ozawa F, Volpe P, et al. Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling. Cell Calcium. 2003;34:177–84.
Kaastrup Müller H, Orlowski D, Reidies Bjarkam C, Wegener G, Elfving B. Potential roles for Homer 1 and Spinophilin in the preventive effect of electroconvulsive seizures on stress-induced CA3c dendritic retraction in the hippocampus. Eur Neuropsychopharmacol. 2015;25:1324–31. PMID: 25935093.
Kaja S, Yang SH, Wei J, Fujitani K, Liu R, Brun-Zinkernagel AM, et al. Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1 L/Homer 1c immunoreactive synaptic connections. Invest Ophthalmol Vis Sci. 2003;44:3155–62.
Kaja S, Sumien N, Borden PK, Khullar N, Iqbal M, Collins JL, Forster MJ, Koulen P. Homer-1a immediate early gene expression correlates with better cognitive performance in aging. Age. 2013;35:1799–808. PMID: 23054826.
Kaja S, Naumchuk Ym Grillo SL, Borden PK, Koulen P. Differential up-regulation of Vesl-1/Homer 1 protein isoforms associated with decline in visual performance in a preclinical glaucoma model. Vis Res. 2014;94:16–23. PMID: 24219919.
Kammermeier PJ. Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons. J Neurosci. 2008;28:8560–7.
Lu J, Helton TD, Blanpied TA, Racz B, Newpher TM, Weinberg RJ, et al. Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Neuron. 2007;55:874–89.
Mahan AL, Mou L, Shah N, Hu JH, Worley PF, Ressler KJ. Epigenetic modulation of Homer 1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning. J Neurosci. 2012;32:4651–9. PMID: 22457511.
Pouliquin P, Dulhunty AF. Homer and the ryanodine receptor. Eur Biophys J. 2009;39:91–102.
Reems J-A, Wang W, Tsubata K, Abdurrahman N, Sundell B, Tijssen MR, et al. Dynamin 3 participates in the growth and development of megakaryocytes. Exp Hematol. 2008;36:1714–27.
Rychkov G, Barritt GJ. TRPC1 Ca(2+)-permeable channels in animal cells. Handb Exp Pharmacol. 2007;179:23–52.
Sakamoto K, Yoshida S, Ikegami K, Minakami R, Kato A, Udo H, et al. Homer 1c interacts with Hippi and protects striatal neurons from apoptosis. Biochem Biophys Res Commun. 2007;352:1–5.
Sgambato-Faure V, Xiong Y, Berke JD, Hyman SE, Strehler EE. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Biochem Biophys Res Commun. 2006;343:630–7.
Shiraishi-Yamaguchi Y, Sato Y, Sakai R, Mizutani A, Knopfel T, Mori N, et al. Interaction of Cupidin/Homer 2 with two actin cytoskeletal regulators, Cdc42 small GTPase and drebrin, in dendritic spines. BMC Neurosci. 2009;10:25.
Stokely M, Hwang S-Y, Hwang J-Y, Fan B, King M, Inokuchi K, Koulen P. Polycystin-1 can interact with Homer 1/Vesl-1 in postnatal hippocampal neurons. J Neurosci Res. 2006;84(8):1727–37.
Tanaka M, Duncan RS, McClung N, Yannazzo JA, Hwang SY, Marunouchi T, et al. Homer proteins control neuronal differentiation through IP(3) receptor signaling. FEBS Lett. 2006;580:6145–50.
Wang F, Zhang Y, Wang L, Sun P, Luo X, Ishigaki Y, Sugai T, Yamamoto R, Kato N. Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice. Neuropharmacology. 2015;97:210–9. PMID: 26051398.
Westhoff JH, Hwang SY, Duncan RS, Ozawa F, Volpe P, Inokuchi K, et al. Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling. Cell Calcium. 2003;34:261–9.
Acknowledgments
This chapter is part of the Encyclopedia of Signaling Molecules, 2nd Edition and is based on a chapter of the same name previously published in the first edition of Encyclopedia of Signaling Molecules. This study was supported in part by grants EY014227 and EY022774 from NIH/NEI; RR022570 and RR027093 from NIH/NCRR and NIH/NIGMS; and AG010485, AG022550, and AG027956 from NIH/NIA, by the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research (PK) and the Dr. John P. and Therese E. Mulcahy Endowed Professorship in Ophthalmology (SK). We thank Margaret, Richard, and Sara Koulen for generous support and encouragement.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Kaja, S., Payne, A.J., Grillo, S.L., Koulen, P. (2018). Homer. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_372
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_372
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences