Synonyms
Historical Background
Classical physiological experiments identified cAMP as a diffusible intracellular secondary messenger capable of activating cAMP-dependent protein kinase (PKA). These studies defined hormone- and location-specific patterns of PKA activation, suggesting that PKA signaling was compartmentalized. For example, in perfused rat cardiomyocytes, adrenergic stimulation selectively activates a pool of PKA isolated from certain fractions, while prostanoids predominately activate cytosolic PKA (Scott et al. 2013).
The first AKAP to be identified, microtubule-associated protein 2 (MAP2), was copurified with the PKA regulatory subunit subtype II (RII) from rat brain extracts. Over 50 additional AKAP family members have subsequently been identified (Fraser and Scott 1999; Scott et al. 2013). AKAPs are structurally diverse and share little primary sequence similarity, but are functionally similar and are classified by their ability to...
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Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, et al. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Mol Cell Neurosci. 2003;22:87–97.
Canton DA, Keene CD, Swinney K, Langeberg LK, Nguyen V, Pelletier L, et al. Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell. 2012. https://doi.org/10.1016/j.molcel.2012.09.002.
Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, et al. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008;32:169–79.
Chen L, Marquardt ML, Tester DJ, Sampson KJ, Ackerman MJ, Kass RS. Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc Natl Acad Sci U S A. 2007;104:20990–5.
Diviani D, Abuin L, Cotecchia S, Pansier L. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J. 2004;23:2811–20.
Fraser ID, Scott JD. Modulation of ion channels: a “current” view of AKAPs. Neuron. 1999;23:423–6.
Gelman IH. Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12. Cancer Metastasis Rev. 2012;31:493–500. https://doi.org/10.1007/s10555-012-9360-1.
Gold MG, Reichow SL, O’Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, et al. AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. EMBO Mol Med. 2012;4:15–26. https://doi.org/10.1002/emmm.201100184.
Hehnly H, Canton D, Bucko P, Langeberg LK, Ogier L, Gelman I, et al. A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. eLife. 2015;4:e09384. https://doi.org/10.7554/eLife.09384.
Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, et al. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012;31:3991–4004. https://doi.org/10.1038/emboj.2012.244.
Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010;37:541–50. https://doi.org/10.1016/j.molcel.2010.01.014.
Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. Identification of a novel protein kinase A anchoring protein that binds both type I and type II reulatory subunits. J Biol Chem. 1997;272:8057–64.
Langeberg LK, Scott JD. Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol. 2015;16:232–44. https://doi.org/10.1038/nrm3966.
Lehnart SE, Marks AR. Phosphodiesterase 4D and heart failure: a cautionary tale. Expert Opin Ther Targets. 2006;10:677–88. https://doi.org/10.1517/14728222.10.5.677.
Li Y, Chen L, Kass RS, Dessauer CW. The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart. J Biol Chem. 2012;287:29815–24. https://doi.org/10.1074/jbc.M112.380568.
Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, et al. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci USA. 2011;108:E1227–35. https://doi.org/10.1073/pnas.1107182108.
Mosenden R, Tasken K. Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells. Cell Signal. 2011;23:1009–16. https://doi.org/10.1016/j.cellsig.2010.11.018.
Nauert JB, Klauck TM, Langeberg LK, Scott JD. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Curr Biol. 1997;7:52–62.
Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, et al. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res. 2010;106:748–56. https://doi.org/10.1161/CIRCRESAHA.109.213363.
Newhall KJ, Criniti AR, Cheah CS, Smith KC, Kafer KE, Burkart AD, et al. Dynamic anchoring of PKA is essential during oocyte maturation. Curr Biol. 2006;16:321–7.
Scott JD, Dessauer CW, Tasken K. Creating order from chaos: cellular regulation by kinase anchoring. Annu Rev Pharmacol Toxicol. 2013;53:187–210. https://doi.org/10.1146/annurev-pharmtox-011112-140204.
Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, et al. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010;12:1242–9. https://doi.org/10.1038/ncb2130.
Smith FD, Reichow SL, Esseltine JL, Shi D, Langeberg LK, Scott JD, et al. Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation. eLife. 2013;2:e01319. https://doi.org/10.7554/eLife.01319.
Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF. Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression. J Biol Chem. 2005;280:16962–8.
Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, et al. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci USA. 2003;100:1723–8.
Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, et al. Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci USA. 2008;105:12557–62.
Whiting JL, Ogier L, Forbush KA, Bucko P, Gopalan J, Seternes OM, et al. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci USA. 2016;113:E4328–37. https://doi.org/10.1073/pnas.1607745113.
Wong W, Scott JD. AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol. 2004;5:959–71.
Zhang J, Carver CM, Choveau FS, Shapiro MS. Clustering and functional coupling of diverse ion channels and signaling proteins revealed by super-resolution STORM microscopy in neurons. Neuron. 2016;92:461–78. https://doi.org/10.1016/j.neuron.2016.09.014.
Acknowledgments
This work was supported by the following grants from the National Institutes of Health: 5R01DK105542 (J.D.S.) and 4P01DK05441 (J.D.S.).
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Gabrovsek, L., Bucko, P., Carnegie, G.K., Scott, J.D. (2018). A-Kinase Anchoring Protein (AKAP). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_218
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DOI: https://doi.org/10.1007/978-3-319-67199-4_218
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