Synonyms
Historical Background
The RIN1 and RIN2 genes were first identified in a selection for expressed human cDNAs that suppress phenotypes associated with oncogenic RAS mutations in a yeast model system (Colicelli et al. 1991). Subsequent analysis demonstrated that RIN1 binds specifically to activated (GTP-bound) human HRAS (Han and Colicelli 1995; Han et al. 1997), suggesting that RIN1 is a downstream effector of RAS family proteins. RIN2 and RIN3 also bind to activated HRAS (Rodriguez-Viciana et al. 2004). All three RIN proteins contain a carboxy terminal RAS association (RA) domain that mediates this interaction (Colicelli (2004)).
It was subsequently reported that RIN1 encodes a VPS9-related guanine nucleotide exchange factor (GEF) function specific for the RAB5 family of early endocytosis GTPase (Tall et al. 2001). RIN2 and RIN3 also encode VPS9-type GEF domains upstream of the RA domain. This suggests that RIN family proteins are RAS effectors...
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Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A. 1997;94(10):4954–9.
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Colicelli, J., Ting, P.Y., Janson, C. (2018). RIN Family Proteins (RIN1, RIN2, and RIN3). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_217
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DOI: https://doi.org/10.1007/978-3-319-67199-4_217
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