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RasGRP1

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Synonyms

Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Guanine nucleotide exchange factor, calcium- and DAG-regulated; MGC129998; MGC129999; Ras guanyl nucleotide-releasing protein 1; Ras guanyl-releasing protein; Ras guanyl-releasing protein 1; RasGRP

Historical Background

Antigen receptor stimulation of T cells and B cells results in the rapid conversion of the small GTPase Ras from its “inactive” GDP-bound form to its “active” GTP-bound form (Alberola-Ila and Hernández-Hoyos 2003). However, the mechanisms of Ras regulation in lymphocytes, particularly by phorbol esters, had long remained a mystery as known signaling pathways could not account for its activation. The discovery of the Ras guanyl-nucleotide exchange factor RasGRP1, cloned by two groups searching for novel Ras activators in rat brain and murine T cells, was a major advance leading to a better understanding of Ras regulation in lymphocytes (Stone 2011). Ectopic expression of RasGRP1 in...

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References

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Correspondence to John J. Priatel .

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Priatel, J.J., Tsai, K., Harder, K.W. (2018). RasGRP1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_154

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