Historical Background
Since the discovery of epidermal growth factor (EGF) in 1962, a total of seven mammalian ligands that bind the EGF receptor (EGFR/ErbB1) have been identified, including transforming growth factor-α (TGFα), amphiregulin (ARG), betacellulin (BTC), epiregulin (ERG), epigen (EPG), and heparin-binding EGF-like growth factor (HB-EGF) (Harris et al. 2003). Historically, HB-EGF was the fourth growth factor to be identified among EGFR-ligands. Major findings regarding HB-EGF are:
Discovery of HB-EGF (Higashiyama et al. 1991)
Identification of HB-EGF as the diphtheria toxin receptor (DTR) (Naglich et al. 1992; Iwamoto et al. 1994)
Identification of HB-EGF’s major role in EGFR transactivation (Prenzel et al. 1999)
Establishment of HB-EGF-null mouse lines (Iwamoto et al. 2003; Jackson et al. 2003)
Proof of the physiological significance of HB-EGF shedding...
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Iwamoto, R., Mekada, E. (2018). HB-EGF (Heparin-Binding EGF-Like Growth Factor). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_127
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