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Encyclopedia of Signaling Molecules pp 5665–5675Cite as

Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4)

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Synonyms

BCYM3; CMT2C; HMSN2C; Osm-9-like TRP channel 4 (OTRPC4); SMAL; SPSMA; SSQTL1; Transient receptor potential protein 12 (TRP12); Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2 (VRL-2); Vanilloid receptor-related osmotically activated channel (VR-OAC)

Historical Background

The transient receptor potential cation channel vanilloid isoform 4 (TRPV4), one of the six members of the TRPV subfamily, is a broadly expressed and versatile vertebrate cellular sensor. It was independently identified using candidate gene strategies as the vanilloid receptor-related osmotically activated channel (VR-OAC) in the central nervous system (CNS) (Liedtke et al. 2000) and the vanilloid receptor-like channel 2 (VRL-2) and osm-9-like TRP channel 4 (OTRPC4) in the kidney, liver, and heart (Strotmann et al. 2000). The gene encodes a nonselective cation channel with a slight preference for calcium (PCa/PNa= 6–10). The channel is a tetramer of four subunits that are polymodally...

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Salt Lake City, UT, 84132, USA

    Sarah N. Redmon & David Križaj

  2. Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan

    Koji Shibasaki

Authors
  1. Sarah N. Redmon
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  2. Koji Shibasaki
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  3. David Križaj
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Correspondence to David Križaj .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Redmon, S.N., Shibasaki, K., Križaj, D. (2018). Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101977

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