Skip to main content
SpringerLink
Log in

Tissue Inhibitor of Metalloproteinase

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

  • 62 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Brew K, Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim Biophys Acta. 2010;1803(1):55–71. doi:10.1016/j.bbamcr.2010.01.003.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen P, McGuire JK, Hackman RC, Kim K-H, Black RA, Poindexter K, et al. Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity. Am J Pathol. 2008;172(5):1256–70. doi:10.2353/ajpath.2008.070891.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chirco R, Liu XW, Jung KK, Kim HRC. Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev. 2006;25:99–113. doi:10.1007/s10555-006-7893-x.

    Article  PubMed  CAS  Google Scholar 

  • Del Campo SEM, Latchana N, Levine KM, Grignol VP, Fairchild ET, Jaime-Ramirez AC, et al. MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor. PLoS One. 2015;10(1):1–19. doi:10.1371/journal.pone.0115919.

    Article  CAS  Google Scholar 

  • Edwards DR, Handsley MM, Pennington CJ. The ADAM metalloproteinases. Mol Asp Med. 2008;29:258–89. doi:10.1016/j.mam.2008.08.001.

    Article  CAS  Google Scholar 

  • Endo K, Takino T, Miyamori H, Kinsen H, Yoshizaki T, Furukawa M, et al. Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. J Biol Chem. 2003;278(42):40764–70. doi:10.1074/jbc.M306736200.

    Article  PubMed  CAS  Google Scholar 

  • Fassina G, Ferrari N, Brigati C, Benelli R, Santi L, Noonan DM, et al. Tissue inhibitors of metalloproteases: regulation and biological activities. Clin Exp Metastasis. 2000;18:111–20. doi:10.1023/A:1006797522521.

    Article  PubMed  CAS  Google Scholar 

  • Gill SE, Pape MC, Leco KJ. Tissue inhibitor of metalloproteinases 3 regulates extracellular matrix-cell signaling during bronchiole branching morphogenesis. Dev Biol. 2006;298:540–54. doi:10.1016/j.ydbio.2006.07.004.

    Article  PubMed  CAS  Google Scholar 

  • Gill SE, Huizar I, Bench EM, Sussman SW, Wang Y, Khokha R, et al. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury. Am J Pathol. 2010;176(1):64–73. doi:10.2353/ajpath.2010.090158.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jung K-K, Liu X-W, Chirco R, Fridman R, Kim H-RC. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 2006;25:3934–42. doi:10.1038/sj.emboj.7601281.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Khokha R, Murthy A, Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nat Rev Immunol. 2013;13:649–65. doi:10.1038/nri3499.

    Article  PubMed  CAS  Google Scholar 

  • Kim HI, Lee H, Kim TH, Lee J, Lee S, Lee S. Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAL, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells. Oncotarget. 2015;6(40):42905–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lorente L, Martín MM, Solé-Vioĺn J, Blanquer J, Labarta L, Díaz C, et al. Association of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio. PLoS One. 2014;9(4):e94318. doi:10.1371/journal.pone.0094318.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Melendez-Zajgla J, Del Pozo L, Ceballos G, Maldonado V. Tissue inhibitor of metalloproteinases-4: the road less traveled. Mol Cancer. 2008;7:85. doi:10.1186/1476-4598-7-85.

    Article  PubMed  PubMed Central  Google Scholar 

  • Murphy G. Tissue inhibitors of metalloproteinases. Genome Biol. 2011;12:233.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Seo D-W, Li H, Qu C-K, Oh J, Kim Y-S, Diaz T, et al. Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J Biol Chem. 2006;281(6):3711–21. doi:10.1074/jbc.M509932200.

    Article  PubMed  CAS  Google Scholar 

  • Stetler-Stevenson WG. Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities. Sci Signal. 2008;1(27):re6. doi:10.1126/scisignal.127re6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, et al. Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4. Circ Heart Fail. 2014;7(4):652–62. doi:10.1161/CIRCHEARTFAILURE.114.001113.

    Article  PubMed  CAS  Google Scholar 

  • Westhoff JH, Tönshoff B, Waldherr S, Pöschi J, Teufel U, Westhoff TH, et al. Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2)- insulin-like growth factor-binding protein 7 (IGFBP7) predicts adverse outcome in pediatric acute kidney injury. PLoS One. 2015;10(11):1–16. doi:10.1371/journal.pone.0143628.

    Article  CAS  Google Scholar 

  • Yan A, Yang C, Chen Z, Li C, Cai L. MiR-761 promotes progression and metastasis of non-small cell lung cancer by targeting ING4 and TIMP2. Cell Physiol Biochem. 2015;37(1):55–66. doi:10.1159/000430333.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada

    Marcello G. Masciantonio & Sean E. Gill

  2. Division of Respirology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Sean E. Gill

  3. Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Sean E. Gill

  4. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Marcello G. Masciantonio & Sean E. Gill

Authors
  1. Marcello G. Masciantonio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sean E. Gill
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sean E. Gill .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Masciantonio, M.G., Gill, S.E. (2018). Tissue Inhibitor of Metalloproteinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101950

Download citation

Publish with us

Policies and ethics

Search

Navigation