Historical Background
The basic leucine-zipper transcription factor, ATF-like (BATF) was first identified from a cDNA library of Epstein-Barr virus (EBV)-stimulated B cells, as a nuclear protein containing a basic leucine-zipper motif. A strong hybridization band for BATF was detected in poly-adenylated mRNA from cell lines and several human tissues such as the lung and Raji Burkitt’s lymphoma by Northern Blot analysis (Dorsey et al. 1995). Only a few months later, another study described a new bZIP transcription factor, which they called SF-HT-activated gene 2 (SFA-2), which was found highly expressed in T and B cells, especially when these cells were transformed by human T cell leukemia virus type I (HTLV-I) (Hasegawa et al. 1996).
Both studies showed that BATF does not form homodimers but builds heterodimers preferentially with Jun-family...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010;207:933–42. https://doi.org/10.1084/jem.20091548.
Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene. 1995;11:2255–65.
Echlin DR, Tae HJ, Mitin N, Taparowsky EJ. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. Oncogene. 2000;19:1752–63. https://doi.org/10.1038/sj.onc.1203491.
Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, et al. IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV. Cell Death Differ. 2014;21:1050–60. https://doi.org/10.1038/cdd.2014.19.
Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. Biochem Biophys Res Commun. 1996;222:164–70. https://doi.org/10.1006/bbrc.1996.0700.
Ikeda S, Saijo S, Murayama MA, Shimizu K, Akitsu A, Iwakura Y. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-beta-induced Foxp3 expression. J Immunol. 2014;192:1449–58. https://doi.org/10.4049/jimmunol.1300387.
Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011;12:536–43. https://doi.org/10.1038/ni.2037.
Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET, Attenasio A, et al. Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest. 2013;123:4641–53. https://doi.org/10.1172/JCI69489.
Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, et al. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol. 2014;15:373–83. https://doi.org/10.1038/ni.2834.
Kuroda S, Yamazaki M, Abe M, Sakimura K, Takayanagi H, Iwai Y. Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression. Proc Natl Acad Sci USA. 2011;108:14885–9. https://doi.org/10.1073/pnas.1105133108.
Li P, Spolski R, Liao W, Wang L, Murphy TL, Murphy KM, et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012;490(7421):543–6. https://doi.org/10.1038/nature11530.
Meyer NP, Johansen LM, Tae HJ, Budde PP, Williams KL, Taparowsky EJ. Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1. Mamm Genome. 1998;9:849–52.
Murphy TL, Tussiwand R, Murphy KM. Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat Rev Immunol. 2013;13:499–509. https://doi.org/10.1038/nri3470.
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, et al. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med. 2010;16:1147–51. https://doi.org/10.1038/nm.2232.
Sahoo A, Alekseev A, Tanaka K, Obertas L, Lerman B, Haymaker C, et al. Batf is important for IL-4 expression in T follicular helper cells. Nat Commun. 2015;6:7997. https://doi.org/10.1038/ncomms8997.
Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009;460:05–9. https://doi.org/10.1038/nature08114.
Senga T, Iwamoto T, Humphrey SE, Yokota T, Taparowsky EJ, Hamaguchi M. Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. Oncogene. 2002;21:8186–91. https://doi.org/10.1038/sj.onc.1205918.
Sopel N, Graser A, Mousset S, Finotto S. The transcription factor BATF modulates cytokine-mediated responses in T cells. Cytokine Growth Factor Rev. 2016;30:39–45. https://doi.org/10.1016/j.cytogfr.2016.03.004.
Ubel C, Sopel N, Graser A, Hildner K, Reinhardt C, Zimmermann T, et al. The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma. J Allergy Clin Immunol. 2014;133:198–206. https://doi.org/10.1016/j.jaci.2013.09.049.e9
Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell. 2012;148:1001–14. https://doi.org/10.1016/j.cell.2012.01.040.
Williams KL, Nanda I, Lyons GE, Kuo CT, Schmid M, Leiden JM, et al. Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Eur J Immunol. 2001;31:1620–7. doi: 10.1002/1521-4141(200105)31:5<1620::AID-IMMU1620>3.0.CO;2-3.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Sopel, N., Finotto, S. (2018). BATF. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101936
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_101936
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences