Background and Discovery of WISP1
Wnt-1 inducible signaling pathway protein 1 (WISP1) is an exciting target for the development of new treatments against acute and chronic disorders that may involve cellular metabolism as well as the nervous, musculoskeletal, cardiac, pulmonary, and vascular systems (Maiese 2014) (Fig. 1). WISP1 also is known as CCN4 and is a member of the CCN family of proteins. The CCN family of proteins consists of six secreted extracellular matrix-associated proteins and is defined by the first three members of the family that include cysteine-rich protein 61, connective tissue growth factor, and nephroblastoma overexpressed gene. Each family member has four cysteine-rich modular domains that include insulin-like growth factor-binding domain,...
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Acknowledgments
This research was supported by the following grants to Kenneth Maiese: American Diabetes Association, American Heart Association, NIH NIEHS, NIH NIA, NIH NINDS, and NIH ARRA.
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Maiese, K. (2018). WISP1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101926
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101926
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