Historical Background
TNF receptor-associated protein 1 (TRAP1) was firstly identified by a yeast-based two-hybrid system as a novel protein binding the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC), hence its name. The protein immediately showed strong sequence homology with members of the heat shock proteins 90-kDa (HSP90) family and variable expression levels in human skeletal muscle, liver, heart, brain, kidney, pancreas, lung, and placenta and in eight different transformed cell lines (Song et al. 1995). A second, independent yeast two-hybrid screening led to the identification of a new heat shock protein functioning as a molecular chaperone for the retinoblastoma protein (Rb). Antibodies prepared against fusion protein between glutathione S-transferase and domains of this new heat shock protein specifically...
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References
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Matassa, D.S., Agliarulo, I., Amoroso, M.R., Avolio, R., Landriscina, M., Esposito, F. (2018). TRAP1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101888
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101888
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