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Encyclopedia of Signaling Molecules pp 5643–5649Cite as

Transient Receptor Potential Cation Channel Subfamily M Member 2

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Synonyms

Classical transient receptor potential 7; Long transient receptor potential channel 2; LTRPC2; Melastatin-related transient receptor potential 2; Transient receptor potential melastatin-related 2; TRPC7; TRPM2

Historical Background

Transient receptor potential (TRP) cation channel subfamily M member 2 (TRPM2) was identified in the search for mammalian genes encoding homologues of the transient receptor potential (Trp) proteins that forms Ca2+-permeable cationic channels required for photo-transduction in Drosophila melanogaster fruit fly (Hardie and Minke 1992). It was firstly named the seventh classical TRP protein (TRPC7) that exhibits sequence relatedness with Drosophila Trp proteins (Nagamine et al. 1998) and subsequently renamed LTRPC2, the second member of the long TRP channel protein family characterized with exceptionally long N- and C-termini (Harteneck et al. 2000). In the efforts devoted to unifying the terminology, the mammalian TRP proteins, 28 in total, are...

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Acknowledgments

SSM is a recipient of Malaysian governmental scholarship. The researches in LHJ's lab described here have been supported by Wellcome Trust, Alzheimer’s Research Trust, Nature Science Foundation of China, Department of Education Henan Province, and Xinxiang Medical University. We apologize that we have not cited the literature in full due to space limitation.

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Authors and Affiliations

  1. School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK

    Lin-Hua Jiang & Sharifah Alawieyah Syed Mortadza

  2. Department of Physiology and Neurobiology, and Sino-UK Joint Laboratory of Brain Function and Injury, Xinxiang Medical University, Xinxiang, Henan, China

    Lin-Hua Jiang

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  1. Lin-Hua Jiang
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  2. Sharifah Alawieyah Syed Mortadza
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Correspondence to Lin-Hua Jiang .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Jiang, LH., Mortadza, S.A.S. (2018). Transient Receptor Potential Cation Channel Subfamily M Member 2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101875

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