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SerpinE1

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References

  • Berkenpas MB, Lawrence DA, Ginsburg D. Molecular evolution of plasminogen activator inhibitor-1 functional stability. EMBO J. 1995;14:2969–77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Brown NJ. Therapeutic potential of plasminogen activator inhibitor-1 inhibitors. Ther Adv Cardiovasc Dis. 2010;4:315–24.

    Article  PubMed  CAS  Google Scholar 

  • Carmeliet P, Kieckens L, Schoojans L, Ream B, Van Nuffelen A, Predergest G, et al. Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest. 2016;92:2746–55.

    Article  Google Scholar 

  • Cochran BJ, Croucher DR, Lobov S, Saunders DN, Ranson M. Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer. J Biol Chem. 2011;286:24467–75.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Croucher DR, Saunders DN, Labov S, Ranson M. Revisiting the biological roles of PAI1 (SERPINB2) in cancer. Nat Rev Cancer. 2008;8:535–45.

    Article  PubMed  CAS  Google Scholar 

  • Czekay R-P, Loskutoff DJ. Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism. J Cell Physiol. 2009;220:655–63.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Czekay R-P, Wilkins-Port CE, Higgins SP, Freytag J, Overstreet JM, Klein RM et al. PAI-1: an integrator of cell signaling and migration. Int J Cell Biol. 2011;201: Article ID 562481. 9 pages. https://doi.org/10.1155/2011/562481.

  • Degryse B, Neels JG, Czekay R-P, Aertgeerts K, Kamikubo Y, Loskutoff DJ. The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1. J Biol Chem. 2004;279:22595–604.

    Article  PubMed  CAS  Google Scholar 

  • Dellas C, Loskutoff DJ. Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease. Thromb Haemost. 2005;93:631–40.

    Article  PubMed  CAS  Google Scholar 

  • Deng G, Curriden SA, Hu G, Czekay R-P, Loskutoff DJ. Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J Cell Physiol. 2001;189:23–33.

    Article  PubMed  CAS  Google Scholar 

  • Dimova EY, Kietzmann T. Metabolic, hormonal and environmental regulation of plasminogen activator inhibitor-1 (PAI-1) expression: lessons from the liver. Thromb Haemost. 2008;100:992–1006.

    Article  PubMed  CAS  Google Scholar 

  • Duffy MJ. Uorkinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: from pilot to level 1 evidence cancer. Clin Chem. 2002;48:1194–7.

    PubMed  CAS  Google Scholar 

  • Fay WP, Parker AC, Condrey LR, Shapiro AD. Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. Blood. 1997;90:204–8.

    PubMed  CAS  Google Scholar 

  • Fearns C, Samad F, Loskutoff DJ. Synthesis and localization of PAI-1 in the vessel wall. In: Vadas M, Harlan J, editors. Vascular control of hemostasis, advances in vascular biology. Victoria: Gordon and Breach Publications; 1996. p. 207–26.

    Google Scholar 

  • Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol. 2012;227:493–507.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Goldfinger LE, Hopkinson SB, deHart GW, Collawn S, Couchman JR, Jones JC. The a3 laminin subunit, a6b4 and a3b1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci. 1999;112:2615–29.

    PubMed  CAS  Google Scholar 

  • Gupta KK, Xu Z, Catellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4. Biochem Biophys Res Commun. 2016;477:503–8.

    Article  PubMed  CAS  Google Scholar 

  • Ji Y, Weng Z, Fish P, Goyal N, Luo M, Myears SP, et al. Pharmacological targeting of plasminogen activator inhibitor-1 decreases vascular smooth muscle cell migration and neointima formation. Arterioscler Thromb Vasc Biol. 2016;36:2167–75.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Law RHP, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, et al. An overview of the serpin superfamily. Genome Biol. 2006;7:216. https://doi.org/10.1186/gb-2006-7-5-216.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Providence KM, Higgins SP, Mullen A, Battista A, Samarakoon R, Higgins CE, et al. SERPINE1 (PAI-1) id desposited into keratinocyte migration “trails” and required for optimal monolayer wound repair. Arch Dermatol Res. 2008;300:303–10.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schleef RR, Wagner NV, Loskutoff DJ. Detection of both type 1 and type 2 plasminogen activator inhibitors in human cells. J Cell Physiol. 1988;134:269–74.

    Article  PubMed  CAS  Google Scholar 

  • Simone TM, Higgins SP, Higgins CE, Lennartz MR, Higgins PJ. Chemical antagonists of plasminogen activator inhibitor-1: mechanisms of action and therapeutic potential in vascular disease. J Mol Genet Med. 2014;8:3. https://doi.org/10.4172/1747-0862.1000125.

    Article  CAS  Google Scholar 

  • Simone TM, Higgins SP, Archambeault J, Higgins CE, Ginnan RG, Singer H, et al. A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell Signal. 2015;27:923–33.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Stefansson S, Muhammad S, Cheng XF, Battey FD, Strickland DK, Lawrence DA. Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein. J Biol Chem. 1998;273:6358–66.

    Article  PubMed  CAS  Google Scholar 

  • Strickland DK, Gonias SL, Argraves WS. Diverse roles for the LDL receptor family. Trends Encrinol Metab. 2002;13:66–74.

    Article  CAS  Google Scholar 

  • Subramanian SV, Fitzgerald ML, Bernfield M. Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 1997;272:14713–20.

    Article  PubMed  CAS  Google Scholar 

  • Toriseva M, Kähäri VM. Proteinases in cutaneous wound healing. Cell Mol Life Sci. 2009;66:203–24.

    Article  PubMed  CAS  Google Scholar 

  • Van den Steen PE, Opdenakker G, Wormald MR, Dwek RA, Rudd PM. Matrix remodelling enzymes, the protease cascade and glycosylation. Biochim Biophys Acta. 2001;1528:61–73.

    Article  PubMed  CAS  Google Scholar 

  • Wind T, Hansen M, Jensen JK, Andreasen PA. The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpine fragment. Biol Chem. 2002;383:21–36.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, 12208, USA

    Ralf-Peter Czekay & Paul J. Higgins

  2. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA

    Tessa M. Simone

Authors
  1. Ralf-Peter Czekay
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  2. Tessa M. Simone
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  3. Paul J. Higgins
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Corresponding author

Correspondence to Paul J. Higgins .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Czekay, RP., Simone, T.M., Higgins, P.J. (2018). SerpinE1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101828

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