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RUNX

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Encyclopedia of Signaling Molecules

Synonyms

RUNX1: Runt-related transcription factor 1; AML1; Acute myeloid leukemia gene 1; PEBP2αB; Polyomavirus enhancer-binding protein 2 alpha B subunit; CBFA2; Core-binding factor subunit alpha-2

RUNX2: Runt-related transcription factor 2; AML3; Acute myeloid leukemia gene 3; PEBP2αA; Polyomavirus enhancer-binding protein 2 alpha A subunit; CBFA1; Core-binding factor subunit alpha-3

RUNX3: Runt-related transcription factor 3; AML2; Acute myeloid leukemia gene 2; PEBP2αC; Polyomavirus enhancer-binding protein 2 alpha C subunit; CBFA3; Core-binding factor subunit alpha-3

Historical Background

RUNX was discovered in the early 1990s by several independent studies. The first RUNX family member to be cloned, Drosophila runt, encodes nuclear protein with no known function and has roles in segmentation, sex determination, and neurogenesis (Kania et al. 1990). Shortly after that, the human RUNX1was sequenced as part of the t(8;21) (q22;q22) chromosomal translocation, a common recurrent...

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References

  • Bae SC, E-i T, Zhang YW, Ogawa E, Shigesada K, Namba Y, et al. Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain. Gene. 1995;159:245–8.

    Article  PubMed  CAS  Google Scholar 

  • Blyth K, Cameron E, Neil J. The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer. 2005;5:376–87.

    Article  PubMed  CAS  Google Scholar 

  • Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, et al. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol. 2005;25:8097–107.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Collins A, Littman D, Taniuchi I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol. 2009;9:106–15.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, Whittaker CA, et al. Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 2010;468:572–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hanai J-i, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo WH, et al. Interaction and functional cooperation of PEBP2/CBF with Smads: synergistic induction of the immunoglobulin germline Cα promoter. J Biol Chem. 1999;274:31577–82.

    Article  PubMed  CAS  Google Scholar 

  • Ito Y. Oncogenic potential of the RUNX gene family: ‘overview’. Oncogene. 2004;23:4198–208.

    Article  PubMed  CAS  Google Scholar 

  • Ito K, Lim ACB, Salto-Tellez M, Motoda L, Osato M, Chuang LSH, et al. RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell. 2008;14:226–37.

    Article  PubMed  CAS  Google Scholar 

  • Ito Y, Bae SC, Chuang LSH. The RUNX family: developmental regulators in cancer. Nat Rev Cancer. 2015;15:81–95.

    Article  PubMed  CAS  Google Scholar 

  • Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, Rostker F, et al. Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature. 2010;468:567–71.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kagoshima H, Shigesada K, Satake M, Ito Y, Miyoshi H, Ohki M, et al. The Runt domain identifies a new family of heterometric transcriptional regulators. Trends Genet. 1993;9:338–41.

    Article  PubMed  CAS  Google Scholar 

  • Kania M, Bonner A, Duffy J, Gergen J. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 1990;4:1701–13.

    Article  PubMed  CAS  Google Scholar 

  • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89:755–64.

    Article  PubMed  CAS  Google Scholar 

  • Lee B, Thirunavukkarasu K, Zhou L, Pastore L, Baldini A, Hecht J, et al. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet. 1997;16:307–10.

    Article  PubMed  CAS  Google Scholar 

  • Lee YS, Lee JW, Jang JW, Chi XZ, Kim JH, Li YH, et al. Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma. Cancer Cell. 2013;24:603–16.

    Article  PubMed  CAS  Google Scholar 

  • Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics. 1994;23:425–32.

    Article  PubMed  CAS  Google Scholar 

  • Linggi B, Müller-Tidow C, van de Locht L, Hu M, Nip J, Serve H, et al. The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nat Med. 2002;8:743–50.

    Article  PubMed  CAS  Google Scholar 

  • Liu P, Tarlé SA, Hajra A, Claxton DF, Marlton P, Freedman M, et al. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science. 1993;261:1041–4.

    Article  PubMed  CAS  Google Scholar 

  • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA. 1991;88:10431–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, et al. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA. 1993a;90:6859–63.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, et al. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila Runt-related DNA binding protein PEBP2 alpha. Virology. 1993b;194:314–31.

    Article  PubMed  CAS  Google Scholar 

  • Okuda T, van Deursen J, Hiebert S, Grosveld G, Downing J. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321–30.

    Article  PubMed  CAS  Google Scholar 

  • Song W, Sullivan M, Legare R, Hutchings S, Tan S, Kufrin D, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet. 1999;23:166–75.

    Article  PubMed  CAS  Google Scholar 

  • Speck NA, Gilliland DG. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer. 2002;2:502–13.

    Article  PubMed  CAS  Google Scholar 

  • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993;13:3324–39.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Weisenberger D, Siegmund K, Campan M, Young J, Long T, Faasse M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006;38:787–93.

    Article  PubMed  CAS  Google Scholar 

  • Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999;18:2551–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore, 117599, Singapore

    Yoshiaki Ito

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  1. Yoshiaki Ito
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Correspondence to Yoshiaki Ito .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Ito, Y. (2018). RUNX. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101825

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