Synonyms
RUFY1: FYVE-finger containing protein; Rab4a interacting protein; Rab4aip; Rabip4; RUN and FYVE domain-containing 1; ZFYVE12
RUFY2: Denn; KIAA1537; LZ-FYVE; Rabip4R; RABIP4R; RUN and FYVE domain-containing 2; ZFYVE13
RUFY3: RIPX; Rap2 interacting protein X; RUN and FYVE domain-containing 3; SINGAR1; Single axon-related 1; ZFYVE30
RUFY4: RUN and FYVE domain-containing 4; ZFYVE31
Historical Background
The RUFY proteins (RUN and FYVE domain-containing protein family) have an amino-terminal RUN domain and a carboxyl-terminal FYVE domain, which associates with phosphatidylinositol 3-phosphate (PI3P) in early endosomes (Yang et al. 2002). As shown in Fig. 1, genome DNA analyses have revealed that a RUFY family consists of four members of RUFY proteins (Yoshida et al. 2010). The RUN domains, named from RPIP8, UNC-14, and NESCA proteins, might function as effectors of the small GTPase superfamily (MacDonald et al. 2004). For example, yeast two-hybrid assays for Rab binding activity...
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Ichimura, M., Nakanishi, A., Kitagishi, Y., Matsuda, S. (2018). Rufy. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101776
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101776
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