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Encyclopedia of Signaling Molecules pp 3860–3864Cite as

PECAM

  • Reference work entry
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Synonyms

CD31 antigen; CD31/EndoCAM; EndoCAM; GPIIA2#′; GPIIA′′; PECA1; PECAM1; PECAM-1; PECAM-1, CD31CD31; Platelet endothelial cell adhesion molecule; Platelet endothelial cell adhesion molecule 1

Historical Background

Platelet endothelial cell adhesion molecule (PECAM) is a 130-kDa membrane glycoprotein and a member of the immunoglobulin (Ig) gene superfamily. PECAM was initially found in platelets (Newman et al. 1982); subsequently, it was also identified in endothelial cells (Newman et al. 1990) and leukocyte subtypes (Dangerfield et al. 2002). Because of its abundant expression in endothelial cells, PECAM is also recognized as an endothelial cell marker for immunohistochemical analyses. PECAM is a multifunctional signaling molecule regulating platelet function, thrombosis, vascular integrity, leukocyte transmigration, and leukocyte immune response (Newman and Newman 2003; Woodfin et al. 2007). In addition, as a critical mechanosensor protein, endothelial PECAM senses fluid shear...

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References

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Authors and Affiliations

  1. RIKEN-Max Planck Joint Research Centre for Systems Chemical Biology, Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Shinobu Kitazume

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  1. Shinobu Kitazume
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Correspondence to Shinobu Kitazume .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Kitazume, S. (2018). PECAM. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101772

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