Skip to main content

PEBP-1

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Al-Mulla F, Bitar MS, Al-Maghrebi M, Behbehani AI, Al-Ali W, Rath O, et al. Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β. Cancer Res. 2011a;71(4):1334–43.

    Article  PubMed  CAS  Google Scholar 

  • Al-Mulla F, Bitar MS, Taqi Z, Rath O, Kolch W. RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility. Mol Biosyst. 2011b;7:928–41.

    Article  PubMed  CAS  Google Scholar 

  • Antoun G, Bouchard-Cannon P, Cheng H-YM. Regulation of MAPK/ERK signaling and photic entrainment of the suprachiasmatic nucleus circadian clock by raf kinase inhibitor protein. J Neurosci. 2012;32(14):4867–77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bernier I, Jolles P. Purification and characterization of a basic 23 kDa cytosolic protein from bovine brain. Biochim Biophys Acta (BBA)/Protein Struct Mol. 1984;790(2):174–81.

    Article  CAS  Google Scholar 

  • Deiss K, Kisker C, Lohse MJ, Lorenz K. Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J Biol Chem. 2012;287(28):23407–17.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Frayne J, Ingram C, Love S, Hall L. Localisation of phosphatidylethanolamine-binding protein in the brain and other tissues of the rat. Cell Tissue Res. 1999;298(3):415–23.

    Article  PubMed  CAS  Google Scholar 

  • Fu Z, Kitagawa Y, Shen R, Shah R, Mehra R, Rhodes D, et al. Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer. Prostate. 2006;66(3):248–56.

    Article  PubMed  CAS  Google Scholar 

  • Han NK, Kim BC, Lee HC, Lee YJ, Park MJ, Chi SG, et al. Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migration. Proteomics. 2012;12(18):2822–32.

    Article  PubMed  CAS  Google Scholar 

  • Hellmann J, Rommelspacher H, Mühlbauer E, Wernicke C. Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells. Dev Neurosci. 2010;32(1):33–46.

    Article  PubMed  CAS  Google Scholar 

  • Lamiman K, Keller JM, Mizokami A, Zhang J, Keller ET. Survey of Raf kinase inhibitor protein (RKIP) in multiple cancer types. Crit Rev Oncog. 2014;19(6):455–68.

    Article  PubMed  Google Scholar 

  • Lee S-J, Lee S-H, Yoon M-H, Park B-J. A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation. Neoplasia. 2013;15(7):727–37.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li D, Cai H, Wang X, Feng Y, Cai S. Promoter methylation of Raf kinase inhibitory protein: a significant prognostic indicator for patients with gastric adenocarcinoma. Exp Ther Med. 2014;8(3):844–50.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lorenz K, Lohse MJ, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature. 2003;426(6966):574–9.

    Article  PubMed  CAS  Google Scholar 

  • Matsukawa N, Furuya Y, Ogura H, Ojika K. HCNP precursor protein transgenic mice display a depressive-like phenotype in old age. Brain Res. 2010;1349:153–61.

    Article  PubMed  CAS  Google Scholar 

  • Ohi Y, Kato D, Mizuno M, Sato T, Ueki Y, Borlongan CV, et al. Enhancement of long-term potentiation via muscarinic modulation in the hippocampus of HCNP precursor transgenic mice. Neurosci Lett. 2015;597:1–6.

    Article  PubMed  CAS  Google Scholar 

  • Ojika K, Mitake S, Tohdoh N, Appel SH, Otsuka Y, Katada E, et al. Hippocampal cholinergic neurostimulating peptides (HCNP). Prog Neurobiol. 2000;60(1):37–83.

    Article  PubMed  CAS  Google Scholar 

  • Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, et al. Analysis of DNA variations in promoter region of HCNP gene with Alzheimer’s disease. Biochem Biophys Res Commun. 2009;379(2):272–6.

    Article  PubMed  CAS  Google Scholar 

  • Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, et al. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nat Med. 2015;21(11):1298–306.

    Article  PubMed  CAS  Google Scholar 

  • Skinner JJ, Rosner MR. RKIP structure drives its function: a three-state model for regulation of RKIP. Crit Rev Oncog. 2014;19(6):483–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tavel L, Jaquillard L, Karsisiotis AI, Saab F, Jouvensal L, Brans A, et al. Ligand binding study of human PEBP1/RKIP: Interaction with nucleotides and raf-1 peptides evidenced by NMR and mass spectrometry. PLoS One. 2012;7(4):e36187.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Theroux S, Pereira M, Casten KS, Burwell RD, Yeung KC, Sedivy JM, et al. Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit. Brain Res Bull. 2007;71:559–67.

    Article  PubMed  CAS  Google Scholar 

  • Tohdoh N, Tojo S, Agui H, Ojika K. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. Brain Res Mol Brain Res. 1995;30(2):381–4.

    Article  PubMed  CAS  Google Scholar 

  • Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, et al. Tissue-based map of the human proteome. Science. 2015;347(6220):394.

    Article  CAS  Google Scholar 

  • Wright KT, AT V. RKIP contributes to IFN- synthesis by CD8+ T cells after serial TCR triggering in systemic inflammatory response syndrome. J Immunol. 2013;191:708–16.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto Y, Lee D, Kim Y, Lee B, Seo C, Kawasaki H, et al. Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation. J Neurosci. 2012;32(41):14254–64.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yesilkanal AE, Rosner MR. Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer. Crit Rev Oncog. 2014;19(6):447–54.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 1999;401(6749):173–7.

    Article  PubMed  CAS  Google Scholar 

  • Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, et al. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000;20(9):3079–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yeung K, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, et al. Raf kinase inhibitor protein interacts with NF-κ B-inducing kinase and TAK1 and inhibits NF-κ B activation. Mol Cell Biol. 2001;21(21):7207–17.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zebisch A, Wölfler A, Fried I, Wolf O, Lind K, Bodner C, et al. Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia. Leukemia. 2012;26(8):1842–9.

    Article  PubMed  CAS  Google Scholar 

  • Zhu S, Mc Henry KT, Lane WS, Fenteany G. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol. 2005;12(9):981–91.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hai-Ying Mary Cheng .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Mendoza-Viveros, L., Cheng, HY.M. (2018). PEBP-1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101762

Download citation

Publish with us

Policies and ethics