Synonyms
LEM6; Ligand effect modulator 6; Peroxisome proliferative-activated receptor, gamma, coactivator 1, alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; PGC-1-alpha; PGC-1v; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC1; PPARGC1A; PPARGC-1-alpha; PRGC1
Historical Background
PGC-1α is the founding member of a small family of transcriptional coactivators that also includes PGC-1β and PRC (PGC-1-related coactivator). The three members of the family share structural features and exert their regulatory action on gene expression by binding and coactivating an overlapping wide range of transcription factors and nuclear receptors. Although each of the PGC-1 coactivators exhibits some specific functional peculiarities, particularly in the cellular context or physiological situation in which they exert their function, the three members of the family are nowadays considered key players in the...
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Villena, J.A. (2018). PGC-1a. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101752
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101752
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