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Encyclopedia of Signaling Molecules pp 3591–3599Cite as

NTCP (Sodium Taurocholate Cotransporting Polypeptide)

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Synonyms

NTCP1; SLC10A1; Sodium/bile acid cotransporter; Solute carrier family 10 member 1

Historical Background

A sodium-dependent transport system for conjugated bile salts was extensively characterized in early studies using perfused rat liver and isolated rat and human basolateral membranes. The factor responsible for the activity of the system was first identified by Dr. Meier’s group in 1990. In their seminal study, they injected rat liver poly (A)+ RNA into Xenopus laevis oocytes and observed the functional expression of sodium-dependent taurocholate uptake (Hagenbuch et al. 1990). Meier and coworkers size-fractionated and enriched the active mRNA, and showed that the 1.5∼3 Kb subfraction supported bile salt uptake. Following expression cloning of a rat cDNA library, they succeeded in cloning rat Ntcp, which consists of 1738 nucleotides that encode an open reading frame and whose expression produces a 362 aa polypeptide (Hagenbuch et al. 1991). NTCP was subsequently cloned from...

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Author information

Author notes

    Authors and Affiliations

    1. Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan

      Senko Tsukuda, Masashi Iwamoto & Koichi Watashi

    Authors
    1. Senko Tsukuda
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    2. Masashi Iwamoto
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    3. Koichi Watashi
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    Corresponding author

    Correspondence to Koichi Watashi .

    Editor information

    Editors and Affiliations

    1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

      Sangdun Choi

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    Tsukuda, S., Iwamoto, M., Watashi, K. (2018). NTCP (Sodium Taurocholate Cotransporting Polypeptide). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101735

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