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Encyclopedia of Signaling Molecules pp 2660–2666Cite as

Intercellular Adhesion Molecule 1

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Synonyms

BB2; CD54; Cluster of differentiation 54; ICAM; ICAM-1; Ly47; MALA-2; p3.58

Historical Background

Intercellular adhesion molecule 1 (ICAM-1; CD54) is a cell adhesion molecule of immunoglobulin (Ig) superfamily expressed by several cell types including leukocytes and endothelial cells with critical involvement in arrest and transmigration of leukocytes from blood vessels into tissues. In 1986, Timothy Springer and his group first described the tissue distribution of ICAM-1 into both hematopoietic cells, (viz. tissue macrophages, mitogen-stimulated T lymphocyte, germinal center den dendritic cells in tonsils, lymph nodes and Peyers pathches) and non-hematopoietic cells, (viz. vascular endothelial cells, thymic epithelial cellscertain other types of epithelial cells and fibroblasts) (Rothlein et al. 1986). In later years, further studies demonstrated that purified ICAM-1 protein acts as a natural ligand for the cell surface lymphocyte function-associated antigen 1 (LFA-1, also...

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References

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Author information

Authors and Affiliations

  1. Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Srirupa Mukhopadhyay

  2. Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Haryana, 133207, India

    Tejinder Pal Khaket & Tapan Kumar Mukherjee

Authors
  1. Srirupa Mukhopadhyay
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  2. Tejinder Pal Khaket
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  3. Tapan Kumar Mukherjee
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Corresponding author

Correspondence to Tapan Kumar Mukherjee .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Mukhopadhyay, S., Khaket, T.P., Mukherjee, T.K. (2018). Intercellular Adhesion Molecule 1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101706

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