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Encyclopedia of Signaling Molecules pp 790–799Cite as

CCL-21

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Synonyms

6Ckine; Beta chemokine exodus-2; Beta-chemokine exodus-2; C-C motif chemokine 21; CCL21; Chemokine (C-C motif) ligand 21; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; Exodus-2; SCYA21; Secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; Small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21; TCA4; UNQ784/PRO1600

Historical Background

Chemokines, a group of homologous yet functionally divergent proteins, mediate leukocyte migration and activation, regulate angiogenesis, and impact immune homeostasis and secondary lymphoid organ architecture. Chemokines are classified into four groups (designated CC, CXC, C, and CXXXC), depending on the spacing or presence of four conserved cysteine residues near their amino-terminus. In the CC subgroup, the first two cysteine residues are adjacent, whereas in the CXC subgroup the first 2 cysteine residues are separated by a nonconserved amino acid residue (hence the CXC...

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Author information

Authors and Affiliations

  1. Molecular Medicine Laboratory, VAGLAHS, David Geffen School of Medicine at UCLA, JCCC Lung Cancer Program, Los Angeles, CA, 90073, USA

    Sherven Sharma & Steven Dubinett

  2. David Geffen School of Medicine at UCLA, JCCC Head and Neck Cancer Program, Los Angeles, CA, 90073, USA

    Sherven Sharma, Maie St. John, Jay M. Lee & Steven Dubinett

Authors
  1. Sherven Sharma
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  2. Maie St. John
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  3. Jay M. Lee
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  4. Steven Dubinett
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Corresponding author

Correspondence to Sherven Sharma .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Sharma, S., John, M.S., Lee, J.M., Dubinett, S. (2018). CCL-21. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101560

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