Historical Background
ATP-binding cassette (ABC) transporters are integral membrane proteins that cross the intracellular (organelles) and cytoplasmic membranes and are involved directly in the transport of substrates against a concentration gradient using ATP hydrolysis. The superfamily of human ABC transporters comprises 49 members and has a wide variety of functions. This family is divided into seven subfamilies from A to G, with the ABC “A” subfamily containing 13 members, such as ABCA1, ABCA2, and ABCA7, which transport sterols. The second member of the ABCA subfamily is named ABCA2. It is expressed at high levels in the white matter of the brain (Halene et al. 2016), as well as oligodendrocytes, schwann cells, excitatory and inhibitory neurons (Mack et al. 2012), brain capillary endothelial cells (Wolf et al. 2012), and glial cells (Macé...
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Aberuyi N, Rahgozar S, Moafi A. The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance. Iran J Ped Hematol Oncol. 2014;4:118.
Barbet R, Peiffer I, Hutchins JR, Hatzfeld A, Garrido E, Hatzfeld JA. Expression of the 49 human ATP binding cassette (ABC) genes in pluripotent embryonic stem cells and in early-and late-stage multipotent mesenchymal stem cells: Possible role of ABC plasma membrane transporters in maintaining human stem cell pluripotency. Cell Cycle. 2012;11:1611–20.
Borel F, Han R, Visser A, Petry H, van Deventer SJ, Jansen PL, et al. Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Hepatology. 2012;55:821–32.
Calpe-Berdiel L, Zhao Y, de Graauw M, Ye D, van Santbrink PJ, Mommaas AM, et al. Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice. Atherosclerosis. 2012;223:332–41.
Davis Jr W. The ATP-binding cassette transporter-2 (ABCA2) overexpression modulates sphingosine levels and transcription of the amyloid precursor protein (APP) gene. Curr Alzheimer Res. 2015;12:847.
Davis Jr W, Chen ZJ, Ile KE, Tew KD. Reciprocal regulation of expression of the human adenosine 5′-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Res. 2003;31:1097–107.
Hadzsiev K, Komlosi K, Czako M, Duga B, Szalai R, Szabo A, et al. Kleefstra syndrome in Hungarian patients: additional symptoms besides the classic phenotype. Mol Cytogenet. 2016;9:1.
Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, et al. NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure. Schizophrenia Research. 2016;170(2–3):235–44.
Hlavác V, Brynychová V, Václavíková R, Ehrlichová M, Vrána D, Pecha V, et al. The expression profile of ATP-binding cassette transporter genes in breast carcinoma. Pharmacogenomics. 2013;14:515–29.
Ile KE, Davis W, Boyd JT, Soulika AM, Tew KD. Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus. Biochim Biophys Acta. 2004;1678:22–32.
Li G, Gu HM, Zhang DW. ATP-binding cassette transporters and cholesterol translocation. IUBMB life. 2013.
Macé S, Cousin E, Ricard S, Génin E, Spanakis E, Lafargue-Soubigou C, et al. ABCA2 is a strong genetic risk factor for early-onset Alzheimer’s disease. Neurobiol Dis. 2005;18:119–25.
Mack JT, Brown CB, Tew KD. ABCA2 as a therapeutic target in cancer and nervous system disorders. Expert Opin Ther Targets. 2008;12:491–504.
Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. 2011;300:154–61.
Rahgozar S, Moafi A, Abedi M, Entezar-E-Ghaem M, Moshtaghian J, Ghaedi K, Esmaeili A, Montazeri F. mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2. 2014;15:35–41.
Takenaka S, Itoh T, Fujiwara R. Expression pattern of human ATP-binding cassette transporters in skin. Pharmacol Res Perspect. 2013;1
Tarling EJ, de Aguiar Vallim TQ, Edwards PA. Role of ABC transporters in lipid transport and human disease. Trends Endocrinol Metabol. 2013;24:342–50.
Thiel G, Müller I, Rössler OG. Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues. Mol Cell Endocrinol. 2014;388:10–9.
Wolf A, Bauer B, Hartz A. ABC transporters and the Alzheimer’s disease enigma. Front Psychiat. 2012;3:54.
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Rahgozar, S., Aberuyi, N., Moafi, H. (2018). ATP-Binding Cassette Subfamily A Member 2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101528
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101528
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