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PPIP5K

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References

  • Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, et al. Inositol pyrophosphates inhibit akt signaling, thereby regulating insulin sensitivity and weight gain. Cell. 2010;143:897–910.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Choi JH, Williams J, Cho J, Falck JR, Shears SB. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J Biol Chem. 2007;282:30763–75.

    Article  PubMed  CAS  Google Scholar 

  • Choi K, Mollapour E, Choi JH, Shears SB. Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol Pharmacol. 2008;74:527–36.

    Article  PubMed  CAS  Google Scholar 

  • Fridy PC, Otto JC, Dollins DE, York JD. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. J Biol Chem. 2007;282:30754–62.

    Article  CAS  PubMed  Google Scholar 

  • Gokhale NA, Zaremba A, Janoshazi AK, Weaver JD, Shears SB. PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains. Biochem J. 2013;453:413–26.

    Article  PubMed  CAS  Google Scholar 

  • Gokhale NA, Zaremba A, Shears SB. Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Biochem J. 2011;434:415–26.

    Article  PubMed  CAS  Google Scholar 

  • Laha D, Johnen P, Azevedo C, Dynowski M, Weiss M, Capolicchio S, et al. VIH2 regulates the synthesis of inositol pyrophosphate InsP8 and jasmonate-dependent defenses in arabidopsis. Plant Cell. 2015;27:1082–97.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee YS, Mulugu S, York JD, O'Shea EK. Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. Science. 2007;316:109–12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Machkalyan G, Trieu P, Petrin D, Hebert TE, Miller GJ. PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility. Cell Signal. 2016;28:401–11.

    Article  CAS  PubMed  Google Scholar 

  • Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, et al. A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science. 2007;316:106–9.

    Article  CAS  PubMed  Google Scholar 

  • Padmanabhan U, Dollins DE, Fridy PC, York JD, Downes CP. Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. J Biol Chem. 2009;284:10571–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pohlmann J, Fleig U. Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in S. pombe. Mol Cell Biol. 2010;30:4535–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pohlmann J, Risse C, Seidel C, Pohlmann T, Jakopec V, Walla E, et al. The vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. PLoS Genet. 2014;10:e1004586.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Tyagi R, et al. Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in type-I interferon response. PLoS Pathog. 2014;10:e1003981.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Thota SG, Bhandari R. The emerging roles of inositol pyrophosphates in eukaryotic cell physiology. J Biosci. 2015;40:593–605.

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Falck JR, Hall TM, Shears SB. Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat Chem Biol. 2012;8:111–6.

    Article  CAS  Google Scholar 

  • Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BVL. Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery. Chem Biol. 2014;21:689–99.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, et al. Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity. Biochemistry. 2015;54:6462–74.

    Article  PubMed  CAS  Google Scholar 

  • Weaver JD, Wang H, Shears SB. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Biosci Rep. 2013;33:228–41.

    Article  CAS  Google Scholar 

  • Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, et al. Identification of a functional nuclear translocation sequence in hPPIP5K2. BMC Cell Biol. 2015;16:17.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Correspondence to Stephen B. Shears .

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Shears, S.B. (2018). PPIP5K. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101515

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