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Mammary Myofibroblastoma

  • Reference work entry
  • First Online:
Breast Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Benign spindle cell tumor; Fibroma; Myogenic stromal tumor

Definition

Myofibroblastoma (MFB) is a relatively rare benign stromal tumor of the breast (Wargotz et al. 1987b; Magro et al. 2001, 2012a; Magro 2016), which belongs to the family of the “benign spindle cell tumors of the mammary stroma” (Magro et al. 2001, 2002a). These tumors are closely related lesions within a continuous morphological spectrum, variably composed of cells ranging from spindly fibroblastic-like cells to plump myofibroblasts (Magro et al. 2001, 2002a). As its name implies, MFB is composed of cells which show myofibroblastic differentiation at morphological, immunohistochemical, and ultrastructural level (Wargotz et al. 1987b; Magro et al. 2001, 2002a, 2016; Magro 2008). Other tumors, such as the benign fibroblastic spindle cell tumor, the spindle cell lipoma of the breast, and tumors with hybrid features, have a fibroblastic profile, with cells stained with vimentin and CD34 by means of...

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele,” Anatomic Pathology Section, School of Medicine, University of Catania, Catania, Italy

    Gaetano Magro & Lucia Salvatorelli

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  1. Gaetano Magro
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  2. Lucia Salvatorelli
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Correspondence to Gaetano Magro .

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Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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Magro, G., Salvatorelli, L. (2020). Mammary Myofibroblastoma. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4724

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