Definition
Microglandular adenosis (MGA) of the breast is a glandular proliferation of uncertain malignant potential, which mimics invasive carcinoma due to haphazard infiltrative growth in breast stroma and the lack of a myoepithelial cell layer. The term atypical microglandular adenosis (AMGA) is used when the glandular structures are more crowded, with a back-to-back architecture and higher variation in size and shape; epithelial proliferation, as well as nuclear atypia and mitotic activity, can be present.
Clinical Features
Incidence
MGA is an exceedingly rare breast lesion.
Age
It affects patients with an age range between adolescence and senescence.
Sex
All reported patients with microglandular adenosis are female.
Site
There is no predilection for a particular quadrant in the breast. MGA can be unifocal or multifocal (Clement and Azzopardi 1983).
Clinical Presentation
MGA usually is asymptomatic and may present as a microscopic lesion or as a palpable mass (Rosen 1983). It can...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Clement, P. B., & Azzopardi, J. G. (1983). Microglandular adenosis of the breast ā A lesion simulating tubular carcinoma. Histopathology, 7, 169ā180.
Foschini, M. P., & Eusebi, V. (2018). Microglandular adenosis of the breast: A deceptive and still mysterious benign lesion. Human Pathology, 82, 1ā9.
Geyer, F. C., Kushner, Y. B., Lambros, M. B., Natrajan, R., Mackay, A., Tamber, N., ā¦ & Reis-Filho, J. S. (2009). Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. Histopathology, 55, 732ā743.
Geyer, F. C., Lacroix-Triki, M., Colombo, P. E., Patani, N., Gauthier, A., Natrajan, R., ā¦ & Marchio, C. (2012). Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. Histopathology, 60, E115āE130.
Geyer, F. C., Berman, S. H., MarchiĆ², C., Burke, K. A., Guerini-Rocco, E., Piscuoglio, S., ā¦ & Schnitt, S. J. (2017). Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family. Modern Pathology, 30, 69.
Guerini-Rocco, E., Piscuoglio, S., Ng, C. K., Geyer, F. C., De Filippo, M. R., Eberle, C. A., ā¦ & Yatabe, Y. (2016). Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations. The Journal of Pathology, 238, 677ā688.
James, B. A., Cranor, M. L., & Rosen, P. P. (1993). Carcinoma of the breast arising in microglandular adenosis. American Journal of Clinical Pathology, 100, 507ā513.
Khalifeh, I. M., Albarracin, C., Diaz, L. K., Symmans, F. W., Edgerton, M. E., Hwang, R. F., & Sneige, N. (2008). Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. The American Journal of Surgical Pathology, 32, 544ā552.
Lakhani, S. R., Ellis, I. O., Schnitt, S. J., Tan, P. H., & van de Vijver, M. J. (2012). WHO classification of tumors of the breast (pp. 106ā107). World Health Organization. Lyon, France. ISBN-10: 9283224337.
Rosen, P. P. (1983). Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. The American Journal of Surgical Pathology, 7, 137ā144.
Rosenblum, M. K., Purrazzella, R., & Rosen, P. P. (1986). Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. The American Journal of Surgical Pathology, 10, 237ā245.
Salarieh, A., & Sneige, N. (2007). Breast carcinoma arising in microglandular adenosis: A review of the literature. Archives of Pathology & Laboratory Medicine, 131, 1397ā1399.
Shin, S. J., Simpson, P. T., Da Silva, L., Jayanthan, J., Reid, L., Lakhani, S. R., & Rosen, P. P. (2009). Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. The American Journal of Surgical Pathology, 33, 496ā504.
Shui, R., & Yang, W. (2009). Invasive breast carcinoma arising in microglandular adenosis: A case report and review of the literature. The Breast Journal, 15, 653ā656.
Tavassoli, F. A., & Bratthauer, G. L. (1993). Immunohistochemical profile and differential diagnosis of microglandular adenosis. Modern Pathology, 6, 318ā322.
Tavassoli, F. A., & Norris, H. J. (1983). Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. The American Journal of Surgical Pathology, 7, 731ā737.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 2020 Springer Nature Switzerland AG
About this entry
Cite this entry
Cascardi, E., MarchiĆ², C., Maiorano, E. (2020). Microglandular Adenosis. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4723
Download citation
DOI: https://doi.org/10.1007/978-3-319-62539-3_4723
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-62538-6
Online ISBN: 978-3-319-62539-3
eBook Packages: MedicineReference Module Medicine