Generic Name
Vortioxetine
Brand Name
Trintellix
Class
Antidepressants, other
Proposed Mechanism(s) of Action
Enhancement of serotonergic activity in the CNS through inhibition of the reuptake of serotonin (5-HT). It also has several other activities including 5-HT3 receptor antagonism and 5-HT1A receptor agonism.
Indication
Major depressive disorder.
Off-Label Use
Neuropathic pain, chronic pain, generalized anxiety disorder, stress urinary incontinence, and fibromyalgia.
Side Effects
Serious
Seizures; hypomania; increased suicidal ideation, attempts, and completion; hyponatremia (SIAH).
Common
Nausea, diarrhea, dry mouth, constipation, vomiting, abnormal dreams, dizziness, weight gain.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Free Drug Online and PDA Software. www.medscapepsychiatry.com
Free Drug Online: CenterWatch. https://www.centerwatch.com/drug-information/fda-approved-drugs/drug/1288/brintellix-vortioxetine
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com: 8080/cgi bin/ddiD4?ver=4&task=getDrugList
Jain, R., Mahableshwarkar, A. R., Jacobsen, P. L., Chen, Y., & Thase, M. E. (2013). A randomized, double-blind, placebo-controlled 6-wk trial of the efficacy and tolerability of 5 mg vortioxetine in adults with major depressive disorder. The International Journal of Neuropsychopharmacology, 16(2), 313–321.
Pill Identification. http://www.drugs.com/pill_identification.html
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Gonzalez, E.A. (2018). Vortioxetine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9270
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9270
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