Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Clinical Neuropsychology pp 1550–1551Cite as

Gene-Environment Interaction

  • Reference work entry
  • First Online:

  • 4 Accesses

Definition

A gene-environment (G-E) interaction refers to the susceptibility of genotypes to different environmental circumstances. In biometrical genetics, it is akin to a statistical interaction such that genetic effects on a phenotype vary as a function of the levels of an environmental variable.

Current Knowledge

Genotype environment interaction refers to changes in the role of genetic factors under different environments. In genetics, this can be visualized as changes in the genetic effect (heritability) on a trait under different environmental conditions (Figs. 1 and 2). In the figures, the evidence of a G-E interaction is that the genetic effect is greater among individuals at the higher end of the environmental measure. Many behaviors and disorders result from the combination of genetic factors and environmental factors, and possibly, their interactions. This has contradicted the early deterministic view of genetics and has opened the door to promising interventions that...

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   899.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   1,099.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References and Readings

  • Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.

    Article  PubMed  Google Scholar 

  • Donnelly, P. (2008). Progress and challenges in genome-wide association studies in humans. Nature Genetics, 456, 728–731.

    Google Scholar 

  • Eaves, L. J. (2006). Genotype x environment interaction in psychopathology: Fact or artefact? Twin Research and Human Genetics, 8, 1–8.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA

    Rohan Palmer

  2. Department of Biology, William Paterson University, Wayne, NJ, USA

    Martin Hahn

Authors
  1. Rohan Palmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Hahn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rohan Palmer .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Palmer, R., Hahn, M. (2018). Gene-Environment Interaction. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1865

Download citation

Publish with us

Policies and ethics

Search

Navigation