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Encyclopedia of Clinical Neuropsychology pp 3550–3551Cite as

Valproate

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Generic Name

Valproate, divalproex sodium

Brand Name

Depakene, Depacon, Depakote, Depakote ER, Depakote Sprinkles, and Stavzor

Class

Anticonvulsants, mood stabilizer, migraine prophylaxis

Proposed Mechanism(s) of Action

While the certain mechanism is unknown, it is believed to block voltage-sensitive sodium channels and to increase brain concentrations of GABA.

Indication

Acute mania, complex partial seizure disorder, simple and complex absence seizures, and migraine prophylaxis

Off-Label Use

Maintenance treatment of bipolar disorder, bipolar depression, psychosis, or schizophrenia

Side Effects

Serious

Polycystic ovaries, hepatoxicity (can be fatal), pancreatitis (can be fatal), and history of inducing suicidal ideation

Common

Sedation, tremor, headache, abdominal pain, diarrhea, decreased appetite, vomiting, constipation, weight gain, hyperandrogenism, hyperinsulinemia, problems controlling lipid level, and diminished bone mineral density

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References and Readings

  • Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.

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  • Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.

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Author information

Authors and Affiliations

  1. Socorro Mental Health, Presbyterian Medical Services, Socorro, NM, USA

    John C. Courtney

  2. College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA

    Efrain Antonio Gonzalez

  3. Utah State University, Logan, UT, USA

    Efrain Antonio Gonzalez

Authors
  1. John C. Courtney
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  2. Efrain Antonio Gonzalez
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Corresponding author

Correspondence to Efrain Antonio Gonzalez .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

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Cite this entry

Courtney, J.C., Gonzalez, E.A. (2018). Valproate. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1721

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