Generic Name
Chlorpromazine
Brand Name
Thorazine
Class
Conventional antipsychotic
Proposed Mechanism(s) of Action
Blocks dopamine 2 receptors, dopamine D2, histamine H1, and cholinergic M1 blockade in the vomiting center (area postrema)
Indication
Schizophrenia, nausea, vomiting, restlessness before surgery, manic episodes of bipolar disorder, and tetanus
Off-Label Use
Bipolar disorder
Side Effects
Serious
Neuroleptic malignant syndrome, jaundice, agranulocytosis, and seizures
Common
Neuroleptic-induced deficit syndrome, akathisia, extrapyramidal symptoms, priapism, and amenorrhea
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References and Readings
Physicians’ desk reference (62nd ed.). (2007). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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Courtney, J.C., Akins, C. (2018). Chlorpromazine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1637
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1637
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