Generic Name
Bupropion, Bupropion hydrobromide
Brand Name
Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Buproban, Budeprion SR, and Forfivo XL
Class
Antidepressants, smoking cessation aids, and dopamine reuptake inhibitors
Proposed Mechanism(s) of Action
Increases norepinephrine/noradrenaline and dopamine, blocks norepinephrine reuptake pump, may increase dopamine neurotransmission in the frontal cortex, and blocks dopamine reuptake pump.
Indication
Major depressive disorder, seasonal affective disorder, and smoking cessation.
Off-Label Use
Bipolar disorder, ADHD, and neuropathic pain.
Side Effects
Serious
Seizures, hypomania, induction of mania, and activation of suicidal ideation (controversial).
Common
Dry mouth, constipation, nausea, weight loss, insomnia, dizziness, headache, agitation, tremor, abdominal pain, tinnitus, tremor, palpitation, anorexia, urinary frequency, and sweating.
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References and Readings
Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Centerwatch: https://www.centerwatch.com/drug-information/fda-approved-drugs/drug/986/aplenzin-bupropion-hydrobromide.
Drug Interaction Effects: http://www.drugs.com/drug_interactions.html.
Drug Molecule Images: http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software: www.epocrates.com.
Free Drug Online and PDA Software: www.medscape.com.
Gene-Based Estimate of Drug interactions: http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList.
Pill Identification: http://www.drugs.com/pill_identification.html.
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Akins, C., Gonzalez, E.A. (2018). Bupropion. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1633
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1633
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