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Clinical Dementia Rating

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Encyclopedia of Clinical Neuropsychology

Synonyms

CDR

Description

The Clinical Dementia Rating (CDR; Hughes et al. 1982) is a semi-structured, clinician-rated interview widely used to stage the progression of dementia using information provided by the patient and an informant. A global CDR score is generated to stage the severity of dementia. It is based on ratings of the patient’s functioning in six domains commonly affected in Alzheimer’s disease (AD): memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. The CDR rates only impairments due to cognitive deficits rather than to physical disability. A number of scoring methods have been developed over the years. In the original protocol, a box score describing the level of impairment is generated for each domain using clinical information based solely from the patient and informant and without reference to psychometric performance. The box score ranges from 0 to 3, representing “none” to “severe” impairment. Using a scoring...

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References and Readings

  • Cedarbaum, J. M., Jaros, M., Hernandez, C., Coley, N., Andrieu, S., Grundman, M., & Vellas, B. (2013). Rationale for use of the Clinical Dementia Rating sum of boxes as a primary outcome measure for Alzheimer’s disease clinical trials. Alzheimer’s & Dementia, 9(1), S45–S55.

    Article  Google Scholar 

  • Chang, Y., Bondi, M. W., McEvoy, L. K., Fennema-Notestine, C., Salmon, D. P., Galasko, D., et al. (2011). Global Clinical Dementia Rating of 0.5 in MCI masks variability related to level of function. Neurology, 76(7), 652–659.

    Article  PubMed  PubMed Central  Google Scholar 

  • Coley, N., Andrieu, S., Jaros, M., Weiner, M., Cedarbaum, J., & Vellas, B. (2011). Suitability of the Clinical Dementia Rating-sum of boxes as a single primary endpoint for Alzheimer’s disease trials. Alzheimer’s & Dementia, 7(6), 602–610.

    Article  Google Scholar 

  • Cortes, F., Nourhashémi, F., Guérin, O., Cantet, C., Gillette-Guyonnet, S., Andrieu, S., et al. (2008). Prognosis of Alzheimer’s disease today: A two-year prospective study in 686 patients from the REAL-FR study. Alzheimer’s & Dementia, 4(1), 22–29.

    Article  Google Scholar 

  • Dooneief, G., Marder, K., Tang, M. X., & Stern, Y. (1996). The Clinical Dementia Rating scale: Community-based validation of ‘profound’ and ‘terminal’ stages. Neurology, 46, 1746–1749.

    Article  PubMed  Google Scholar 

  • Gelb, D. J., & St. Laurent, R. T. (1993). Alternative calculation of the Global Clinical Dementia Rating. Alzheimer Disease and Associated Disorders, 7(4), 202–211.

    Article  PubMed  Google Scholar 

  • Hughes, C. P., Berg, L., Danziger, W. L., Coben, L. A., & Martin, R. L. (1982). A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566–572.

    Article  PubMed  Google Scholar 

  • Knopman, D. S., Weintraub, S., & Pankratz, V. S. (2011). Language and behavior domains enhance the value of the Clinical Dementia Rating scale. Alzheimer’s & Dementia, 7(3), 293–299.

    Article  Google Scholar 

  • Lowe, D. A., Balsis, S., Miller, T. M., Benge, J. F., & Doody, R. S. (2012). Greater precision when measuring dementia severity: Establishing item parameters for the Clinical Dementia Rating scale. Dementia and Geriatric Cognitive Disorders, 34(2), 128–134.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lynch, C., Walsh, C., Blanco, A., Moran, M., Coen, R., Walsh, J., et al. (2006). The Clinical Dementia Rating sum of box score in mild dementia. Dementia and Geriatric Cognitive Disorders, 21(1), 40–43.

    Article  PubMed  Google Scholar 

  • Marin, D., Flynn, S., Mare, M., Lantz, M., Hsu, M., Laurans, M., et al. (2001). Reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale. International Journal of Geriatric Psychiatry, 16(8), 745–750.

    Article  PubMed  Google Scholar 

  • Morris, J. C. (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43(11), 2412–2414.

    Article  PubMed  Google Scholar 

  • O’Bryant, S. E., Lacritz, L. H., Hall, J., Waring, S. C., Chan, W., Khodr, Z. G., et al. (2010). Validation of the new interpretive guidelines for the Clinical Dementia Rating scale sum of boxes score in the national Alzheimer’s coordinating center database. Archives of Neurology, 67(6), 746–749.

    PubMed  PubMed Central  Google Scholar 

  • Oremus, M., Perrault, A., Demers, L., & Wolfson, C. (2000). A review of outcome measurement instruments in Alzheimer’s disease drug trials: Psychometric properties of global scales. Journal of Geriatric Psychiatry and Neurology, 13(4), 197–205.

    Article  PubMed  Google Scholar 

  • Perneczky, R., Hartmann, J., Grimmer, T., Drzezga, A., & Kurz, A. (2007). Cerebral metabolic correlates of the Clinical Dementia Rating scale in mild cognitive impairment. Journal of Geriatric Psychiatry and Neurology, 20(2), 84–88.

    Article  PubMed  Google Scholar 

  • Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., et al. (2005). Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352(23), 2379–2388.

    Article  PubMed  Google Scholar 

  • Rikkert, M. G. M. O., Tona, K. D., Janssen, L., Burns, A., Lobo, A., Robert, P., et al. (2011). Validity, reliability, and feasibility of clinical staging scales in dementia: A systematic review. American Journal of Alzheimer’s Disease and Other Dementias, 26(5), 357–365.

    Article  PubMed  Google Scholar 

  • Russo, G., Russo, M. J., Buyatti, D., Chrem, P., Bagnati, P., Suarez, M. F., et al. (2014). Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration. Journal of the Neurological Sciences, 344(1–2), 63–68.

    Article  PubMed  Google Scholar 

  • Saito, Y., & Murayama, S. (2007). Neuropathology of mild cognitive impairment. Neuropathology, 27(6), 578–584.

    Article  PubMed  Google Scholar 

  • Schafer, K., Tractenberg, R., Sano, M., Mackell, J., Thomas, R., Gamst, A., et al. (2004). Reliability of monitoring the Clinical Dementia Rating in multicenter clinical trials. Alzheimer Disease and Associated Disorders, 18(4), 219–222.

    PubMed  PubMed Central  Google Scholar 

  • Senanarong, V., Chen, C., & Orgogozo, J. (2006). Third Asia-Pacific regional meeting of the International Working Group on Harmonization of Dementia Drug Guidelines: Meeting report summary. Alzheimer Disease and Associated Disorders, 20(4), 311–312.

    Article  PubMed  Google Scholar 

  • Williams, M. M., Roe, C. M., & Morris, J. C. (2009). Stability of the Clinical Dementia Rating, 1979–2007. Archives of Neurology, 66(6), 773–777.

    Article  PubMed  PubMed Central  Google Scholar 

  • Williams, M. M., Storandt, M., Roe, C. M., & Morris, J. C. (2013). Progression of Alzheimer’s disease as measured by Clinical Dementia Rating sum of boxes scores. Alzheimer’s & Dementia, 9(1), S39–S44.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Neurology, University of British Columbia, Vancouver, BC, Canada

    Jing Ee Tan

  2. Vancouver General Hospital, Vancouver, BC, Canada

    Jing Ee Tan

  3. Department of Psychology, University of Victoria, Victoria, BC, Canada

    Jing Ee Tan & Esther Strauss

  4. Copeman Healthcare Centre, Calgary, AB, Canada

    Elisabeth M. S. Sherman

Authors
  1. Jing Ee Tan
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  2. Esther Strauss
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  3. Elisabeth M. S. Sherman
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Editor information

Editors and Affiliations

  1. Richmond, Virgin Islands, USA

    Jeffrey Kreutzer

  2. Kessler Foundation , West Orange, New Jersey, USA

    John DeLuca

  3. Suite 200 , Wynnewood, Pennsylvania, USA

    Bruce Caplan

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Tan, J.E., Strauss, E., Sherman, E.M.S. (2018). Clinical Dementia Rating. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_533-2

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  • DOI: https://doi.org/10.1007/978-3-319-56782-2_533-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56782-2

  • Online ISBN: 978-3-319-56782-2

  • eBook Packages: Springer Reference Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences

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