Embryopathy as a Model for the Epigenetics Regulation of Complications in Diabetes

Dong, Daoyin; Reece, E. Albert; Yang, Peixin

doi:10.1007/978-3-319-55530-0_102

Embryopathy as a Model for the Epigenetics Regulation of Complications in Diabetes

The Roles of miRNA, DNA Methylation, and Histone Modification in Induction of Diabetic Embryopathy

Daoyin Dong³,
E. Albert Reece³ &
Peixin Yang^3,4

Reference work entry
First Online: 05 January 2019

140 Accesses

Abstract

Pregestational diabetes mellitus is a serious public health problem and a high-risk factor for diabetes-associated birth defects, such as neural tube defects (NTDs), congenital heart defects (CHDs), and susceptibility to postnatal diseases in the offspring. Over the past several decades, studies on the etiology of diabetic embryopathy have implicated epigenetic factors as an underlying cause for maternal diabetes-induced congenital developmental defects. Three epigenetic modalities – microRNA (miRNA), DNA methylation, and histone modification – are possible pathological pathways causing diabetic embryopathy. This chapter discusses the implication of epigenetic alterations in causing diabetic embryopathy. We highlight current studies which have demonstrated that maternal diabetes-altered miRNAs, DNA methylation, and histone modifications disturb embryonic developmental processes via inhibition of genes involved in stem cell proliferation and differentiation and activation of proapoptotic genes, thereby leading to embryonic malformation. Despite these promising studies, the detailed roadmap of how maternal diabetes causes epigenetic alterations which contribute to diabetic embryopathy is still elusive.

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Abbreviations

ASK1:: Apoptosis signal-regulating kinase 1
CHD:: Congenital heart defect
Cited2:: CBP/p300-interacting transactivator with ED-rich tail 2
CLDN1:: Claudin 1
CTGF:: Connective tissue growth factor
Dcx:: Doublecortin
DM:: Diabetes mellitus
Dnmt:: DNA methyltransferase
ER:: Endoplasmic reticulum
Est1:: E26 avian leukemia oncogene 1, 5′ domain
GATA4:: GATA binding protein 4
Grhl3:: Grainyhead like transcription factor 3
GSK3β:: Glycogen synthase kinase-3 beta
H3K14ac:: Histone 3 lysine 14 acetylation
H3K27ac:: Histone 3 lysine 27 acetylation
H3K56ac:: Histone 3 lysine 56 acetylation
H3K9ac:: Histone 3 lysine 9 acetylation
H3K9me3:: Histone 3 lysine 9 trimethylation
H4K16ac:: Histone 4 lysine 16 acetylation
IGF-1:: Insulin-like growth factor 1
IRE1α:: Inositol-requiring enzyme 1 alpha
Mef2c:: Myocyte enhancer factor 2C
microRNA:: miRNA
MSX1:: msh homeobox 1
MTHFR:: Methylenetetrahydrofolate reductase
NTD:: Neural tube defect
Pafah1b1:: Platelet activating factor acetyl hydrolase, isofrom 1b, subunit 1
Pax3:: Paired box 3
SIRT:: Sirtuin
STAT3:: Signal transducer and activator of transcription 3
TRAF3:: TNF receptor-associated factor 3
TSP1:: Thrombospondin 1
Tulp3:: Tubby like protein 3
Txnip:: Thioredoxin-interacting protein
Zeb2:: Zinc finger E-box binding homeobox 2
5MC:: 5-methylcytosine

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Authors and Affiliations

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
Daoyin Dong, E. Albert Reece & Peixin Yang
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA
Peixin Yang

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Daoyin Dong
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E. Albert Reece
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Peixin Yang
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Correspondence to Peixin Yang .

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Editors and Affiliations

School of Life Sciences, University of Westminster, London, UK
Vinood B. Patel
Diabetes and Nutritional Sciences Research Division, Faculty of Life Sciences and Medicine, King’s College London, London, UK
Victor R. Preedy

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Dong, D., Reece, E.A., Yang, P. (2019). Embryopathy as a Model for the Epigenetics Regulation of Complications in Diabetes. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-55530-0_102

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DOI: https://doi.org/10.1007/978-3-319-55530-0_102
Published: 05 January 2019
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-55529-4
Online ISBN: 978-3-319-55530-0
eBook Packages: MedicineReference Module Medicine

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