Skip to main content
SpringerLink
Log in

Jaboticaba: Chemistry and Bioactivity

  • Living reference work entry
  • First Online:
Book cover Bioactive Molecules in Food

Part of the book series: Reference Series in Phytochemistry ((RSP))

  • 335 Accesses

Abstract

The jaboticaba is a fruit native to Brazil that grows in the wild throughout the country but is also cultivated on a low-scale basis by small farmers. Research is currently being reported that jaboticaba is a rich source of bioactive compounds, particularly the phenolic compounds. For example, high levels of the anthocyanins, cyanidin-3-O-glucoside and delphinidin-3-O-glucoside, and ellagitannins/ellagic acid are the predominant phenols present in jaboticaba and reside primarily in the peel and seeds of the fruit. These substances have been linked to multiple health benefits, including the prevention and/or mitigation of oxidation, inflammation, atherosclerosis risk factors, cancer, and conditions involved with metabolic syndrome. The fruit, or substances therein, has also been shown to enhance the immune system and gut microbiome. Therefore, the objective of this manuscript is to review the health-promoting properties exerted by jaboticaba or the compounds that reside in the fruit demonstrated throughout the literature, with an emphasis on the phenols.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Abbreviations

ATP:

Adenine triphosphate (ATP)

CD40:

Cluster of differentiation 40 protein

CD83:

Cluster of differentiation 83 protein

CD86:

Cluster of differentiation 86 protein

DNA:

Deoxyribonucleic acid

GI:

Gastrointestinal

H2O2:

Hydrogen peroxide

hBD-:

Human beta defensin 2

HDL:

High-density lipoprotein

HDL-C:

High-density lipoprotein cholesterol

HIV:

Human immunodeficiency virus

iNOS:

Inducible nitric oxide synthase

LDL:

Low-density lipoprotein

LDL-C:

Low-density lipoprotein cholesterol

LOX-1:

Lectin-like oxidized low-density lipoprotein receptor

MetS:

Metabolic syndrome

MMP:

Matrix metalloproteinase

NO:

Nitric oxide

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

SLP1:

Secretory leukocyte protease inhibitor

TC:

Total cholesterol

w/w:

Weight/weight

References

  1. Santos DT, Veggi PC, Meirele AA (2010) Extraction of antioxidant compounds from Jabuticaba (Myrciaria cauliflora) skins: yield, composition and economical evaluation. J Food Eng 10:23–31

    Article  CAS  Google Scholar 

  2. Neves LC, da Silva VX, Benedette RM, Prill MADS, Vieites RL, Roberto SR (2008) Conservação de uvas “Crimson Seedless” e “Itália”, submetidas a diferentes tipos de embalagens e dióxido de enxofre (SO2). Rev Bras Frutic 30:65–73

    Article  Google Scholar 

  3. Abe LT, Lajolo FM, Genovese MI (2012) Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: jaboticaba (Myrciaria jaboticaba (Vell.) Berg). J Sci Food Agric 92:1679–1687

    Article  CAS  Google Scholar 

  4. Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D (2007) Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51:675–683

    Article  CAS  Google Scholar 

  5. He J, Giusti MM (2010) Anthocyanins: natural colorants with health promoting properties. Annu Rev Food Sci Technol 1:163–187

    Article  CAS  Google Scholar 

  6. Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Kadota T, Koda T, Nakamura M, Imaida K, Ito N (2001) Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1, 2-dimethylhydrazine. Cancer Lett 171:17–25

    Article  CAS  Google Scholar 

  7. Sriamornsak P (2011) Application of pectin in oral drug delivery. Exp Opin Drug Del 8:1009–1023

    Article  CAS  Google Scholar 

  8. Francis FJ, Markakis PC (1989) Food colorants: anthocyanins. Crit Rev Food Sci Nutr 28:273–314

    Article  CAS  Google Scholar 

  9. Inada KOP, Oliveira AA, Revorêdo TB, Martins ABN, Lacerda ECQ, Freire AS, Braz BF, Santelli RE, Torres AG, Perrone D, Monteiro MC (2015) Screening of the chemical composition and occurring antioxidants in jaboticaba (Myrciaria jaboticaba) and jussara (Euterpe edulis) fruits and their fractions. J Funct Foods 17:422–433

    Article  CAS  Google Scholar 

  10. Obtained from https://en.wikipedia.org/wiki/Jabuticaba. Accessed on 31 Dec 201

  11. Wu S-B, Long C, Kennelly EJ (2013) Phytochemistry and health benefits of jaboticaba, an emerging fruit crop from Brazil. Food Res Int 54:148–159

    Article  CAS  Google Scholar 

  12. Lenquiste SA, Marineli RDS, Moraes ÉA, Dionísio AP, Brito ESD, Maróstica MR Jr (2015) Jaboticaba peel and jaboticaba peel aqueous extract shows in vitro and in vivo antioxidant properties in obesity model. Food Res Int 77:162–170

    Article  Google Scholar 

  13. Alezandro MR, Dubé P, Desjardins Y, Lajolo FM, Genovese MI (2013) Comparative study of chemical and phenolic compositions of two species of jaboticaba (Myrciaria jaboticaba (Vell) Berg and Myrciaria cauliflora (Mart) O. Berg). Food Res Int 54:468–477

    Article  CAS  Google Scholar 

  14. da Silva JK, Batista ÂG, Cazarin CBB, Dionísio AP, de Brito ES, Marques ATB, Maróstica MR Jr (2017) Functional tea from a Brazilian berry: overview of the bioactives compounds. LWT Food Sci Technol 76:292–298

    Article  CAS  Google Scholar 

  15. Lima ADJB, Corrêa AD, Dantas-Barros AM, Nelson DL, Amorim ACL (2011) Sugars, organic acids, minerals and lipids in jaboticaba. Rev Bras Frutic 33:540–550

    Article  Google Scholar 

  16. Rufino MDSM, Alves RE, de Brito ES, Pérez-Jiménez J, Saura-Calixto F, Mancini-Filho J (2010) Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chem 121:996–1002

    Article  CAS  Google Scholar 

  17. Gurak PD, De Bona GS, Tessaro IC, Marczak LDF (2014) Jaboticaba pomace powder obtained as a co-product of juice extraction: a comparative study of powder obtained from peel and whole fruit. Food Res Int 62:786–792

    Article  CAS  Google Scholar 

  18. Leite-Legatti AV, Batista ÂG, Dragano NRV, Marques AC, Malta LG, Riccio MF, Eberlin MN, Machado ART, de Carvalho-Silva LB, Ruiz ALTG, de Carvalho JE, Pastore GM, Maróstica MR (2012) Jaboticaba peel: antioxidant compounds, antiproliferative and antimutagenic activities. Food Res Int 49:596–603

    Article  CAS  Google Scholar 

  19. Batista ÂG, Lenquiste SA, Cazarin CBB, da Silva JK, Luiz-Ferreira A, Bogusz SB Jr, Souza RN, Augusto F, Prado MA, Maróstica MR Jr (2014) Intake of jaboticaba peel attenuates oxidative stress in tissues and reduces circulating saturated lipids of rats with high fat diet induced obesity. J Funct Foods 6:450–461

    Article  CAS  Google Scholar 

  20. Batista ÂG, Soares ES, Mendonça MCP, da Silva JK, Dionísio AP, Sartori CR, da Cruz-Höfling MA, Maróstica MR Jr (2017) Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Mol Nutr Food 61(10):1600952

    Article  CAS  Google Scholar 

  21. Plaza M, Batista ÂG, Cazarin CBB, Sandahl M, Turner C, Östman E, Maróstica MR Jr (2016) Characterization of antioxidant polyphenols from Myrciaria jaboticaba peel and their effects on glucose metabolism and antioxidant status: a pilot clinical study. Food Chem 211:185–197

    Article  CAS  Google Scholar 

  22. Miguel MG (2010) Antioxidant activity of medicinal and aromatic plants. A review. Flavour Frag J 25:291–312

    Article  CAS  Google Scholar 

  23. Dai J, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15:7313–7352

    Article  CAS  Google Scholar 

  24. Toyokuni S, Tanaka T, Kawaguchi W, Fang N, Ozeki RL, Akatsuka M, Hiai S, Okezie H, Aruoma OI, Bahorun T (2003) Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes. Free Radic Res 37:1215–1224

    Article  CAS  Google Scholar 

  25. Naga OA, Seki M, Kobayashi H (1999) Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 63:1787–1790

    Article  Google Scholar 

  26. Yeh C-T, Yen G-C (2006) Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance – associated protein 3 mRNA expression. J Nutr 136:11–15

    Article  CAS  Google Scholar 

  27. Masella R, Di Benedetto R, Vari R, Filesi C, Giovanin C (2005) Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem 16:577–586

    Article  CAS  Google Scholar 

  28. Haminiuk CWI, Plata-Oviedo MSV, Guedes AR, Stafussa AP, Bona E, Carpes ST (2011) Chemical, antioxidant and antibacterial study of Brazilian fruits. Food Sci Technol 46:1529–1537

    CAS  Google Scholar 

  29. Leite AV, Malta LG, Riccio MF, Eberlin MN, Pastore GM, Maróstica MR Jr (2011) Antioxidant potential of rat plasma by administration of freeze-dried jaboticaba peel (Myrciaria jaboticaba Vell Berg). J Agric Food Chem 59:2277–2283

    Article  CAS  Google Scholar 

  30. Calloni C, Agnol RD, Martínez LS, Maron FS, Moura S, Salvador M (2015) Jaboticaba (Plinia trunciflora (O. Berg) Kausel) fruit reduces oxidative stress in human fibroblast cells (MRC-5). Food Res Int 70:15–22

    Article  CAS  Google Scholar 

  31. Martins de Sá LZC, Castro PFS, Lino FMA, Bernardes MJC, Viegas JCJ, Dinis TCP, Santana MJ, Romao W, Vaz BGV, Lião LM, Ghedini PC, Rocha ML, Gil ES (2014) Antioxidant potential and vasodilatory activity of fermented beverages of jaboticaba berry (Myrciaria jaboticaba). J Funct Foods 8:169–179

    Article  CAS  Google Scholar 

  32. Garcia-Diaz DF, Jimenez P (2013) Bioactive compounds and health benefits of exotic tropical red- black berries. J Funct Foods 5:539–549

    Article  CAS  Google Scholar 

  33. Wang W-H, Tyan Y-C, Chen Z-S, Lin C-G, Yang M-H, Yuan S-S, Tsai W-C (2014) Evaluation of the antioxidant activity and antiproliferative effect of the jaboticaba (Myrciaria cauliflora) seed extracts in oral carcinoma cells. Biomed Res Int. https://doi.org/10.1155/2014/185946

  34. Silva MC, de Sousa VB, Thomazini M, da Silva ER, Smaniotto T, de Carvalho RA, Genovese MI, Favaro-Trindade CS (2014) Use of the jaboticaba (Myrciaria cauliflora) depulping residue to produce a natural pigment powder with functional properties. LWT-Food Sci Technol 55:203–209

    Article  CAS  Google Scholar 

  35. Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharmacol Therap 96:267–202

    Article  Google Scholar 

  36. Tsuda T (2012) Dietary anthocyanin rich plants: biochemical basis and recent progress in health benefits studies. Mol Nutr Food Res 56:159–170

    Article  CAS  Google Scholar 

  37. Kähkönen MP, Heinonen M (2003) Antioxidant activity of anthocyanins and their aglycons. J Agric Food Chem 51:628–633

    Article  CAS  Google Scholar 

  38. Tsuda T, Horio F, Osawa T (2000) The role of anthocyanins as an antioxidant under oxidative stress in rats. Biofactors 13:133–139

    Article  CAS  Google Scholar 

  39. Ramirez-Tortosa C, Andersen ØM, Gardner PT, Morrice PC, Wood SG, Duthie SJ, Collins AR, Duthie GG (2001) Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. Free Radic Biol Med 31:1033–1037

    Article  CAS  Google Scholar 

  40. Priyadarsini KI, Khopde SM, Dumar SS, Mohan H (2002) Free radical studies of ellagic acid, a natural phenolic antioxidant. J Agric Food Chem 50:2200–2206

    Article  CAS  Google Scholar 

  41. Han DH, Lee MJ, Kim JH (2006) Antioxidant and apoptosis-induct activity of ellagic acid. Anticancer Res 26:3601–3606

    CAS  Google Scholar 

  42. Aglitti FF, Duranti G, Rcordy R, Perticone P, Cozzi R (2001) Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay. Anticancer Res 21:3903–3908

    Google Scholar 

  43. Meyer AS, Heinonen M, Frankel EN (1998) Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation. Food Chem 61:71–75

    Article  CAS  Google Scholar 

  44. Turk G, Atessahin A, Sonmez M, Ceribasi AO, Yuce A (2008) Improvements of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertil Steril 89:1474–1481

    Article  CAS  Google Scholar 

  45. O’Byrne KJ, Dalgleish AG (2001) Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer 85:473–483

    Article  Google Scholar 

  46. Lumeng CN, Bodzin JL, Saltiel A (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175–184

    Article  CAS  Google Scholar 

  47. Wellen KE (2005) Inflammation, stress and diabetes. J Clin Invest 115:1111–1119

    Article  CAS  Google Scholar 

  48. Lionett L, Mollica MP, Lombardi A, Cavaliere G, Gifuni G, Barletta A (2009) From chronic overnutrition to insulin resistance the role of fat storing capacity and inflammation. Nutr Metab Cardiovasc Dis 19:146–152

    Article  CAS  Google Scholar 

  49. Chan BCL, Li LF, Hu SQ, Wat E, Wong ECW, Zhang VX, Lau CBS, Wong CK, Hon KLE, Hui PCL (2015) Gallic acid is the major active component of Cortex Moutan in inhibiting immune maturation of human monocyte-derived dendritic cells. Mol Ther 20:16388–16403

    CAS  Google Scholar 

  50. Dale BA (2002) Periodontal epithelium: a newly recognized role in health and disease. Periodontol 2000(30):70–78

    Article  Google Scholar 

  51. Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW (1999) p53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett 136:215–221

    Article  CAS  Google Scholar 

  52. Fakhry C, Marks MA, Gilman RH, Cabrerra L, Yori P, Kosek M, Gravitt PE (2013) Comparison of the immune microenvironment of the oral cavity and cervix in healthy women. Cytokine 64:597–604

    Article  CAS  Google Scholar 

  53. Schröder J-M, Harder J (1999) Human beta-defensin-2. Int J Biochem Cell Biol 31:645–651

    Article  Google Scholar 

  54. QuiÃones-Mateu ME, Lederman MM, Feng Z, Chakraborty B, Weber J, Rangel HR, Marotta ML, Mirza M, Jiang B, Kiser P (2003) Human epithelial Î2-defensins 2 and 3 inhibit HIV-1 replication. AIDS 17:F39–F48

    Article  Google Scholar 

  55. Promsong A, Chung WO, Satthakarn S, Nittayananta W (2014) Ellagic acid modulates the expression of oral innate immune mediators: potential role in mucosal protection. J Oral Pathol Med 44:214–221

    Article  CAS  Google Scholar 

  56. Modi MN, Goel T, Das T, Malik S, Suri S, Rawas AKS, Srivastava SK, Tuli R, Malhotra S, Gupta SK (2013) Ellagic acid and gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through the inhibition of HIV-1 protease and reverse transcriptase activity. Indian J Med Res 137:540–548

    Google Scholar 

  57. Jenning A, Welch AA, Spector T, Macgregar A, Cassidy A (2014) Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr 144:202–208

    Article  CAS  Google Scholar 

  58. Hassellund SS, Flaa A, Kjeldsen SE, Seljeflot I, Karlsen A, Erlund I, Rstrup M (2013) Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: a double-blind randomized placebo controlled crossover study. J Hum Hypertens 27:100–106

    Article  CAS  Google Scholar 

  59. Mena P, Dominguez-Perles R, Girones-Vilaplan A, Baenas N, Garcia-Viguera C, Villano D (2014) Flavan-3-ols, anthocyanins, and inflammation. Lifestyles 66:745–758

    CAS  Google Scholar 

  60. Landete JM (2011) Ellagitannins, ellagic acid and their derived metabolites: a review about source, metabolism functions and health. Food Res Int 44:1150–1160

    Article  CAS  Google Scholar 

  61. Siegel RL, Miller KD, Jemal A (2016) Cancer statistics. CA Cnacer J Clin 66:7–30

    Article  Google Scholar 

  62. Adams J, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26:1324–1337

    Article  CAS  Google Scholar 

  63. Zee Y-K, O’connor JP, Parker GJ, Jackson A, Clamp AR, Taylor MB, Clarke NW, Jayson GC (2010) Imaging angiogenesis of genitourinary tumors. Nat Rev Urol 7:69–82

    Article  Google Scholar 

  64. Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883–899

    Article  CAS  Google Scholar 

  65. Palmer S (1985) Diet, nutrition and cancer. Prog Food Nutr Sci 9:283–341

    CAS  Google Scholar 

  66. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hipert DF, Griel AE, Etherton TD (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113:71–88

    Article  Google Scholar 

  67. Losso JN, Bansode RR, Trappey A II, Bawadi HA, Truax R (2004) In vitro anti-proliferative activities of ellagic acid. J Nutr Biochem 15:672–678

    Article  CAS  Google Scholar 

  68. Edderkaoui M, Odinokova I, Ohno I, Gukovshky I, Go VLW, Pandol SJ, Gukovskaya AS (2008) Ellagic acid induces apoptosis through inhibition of nuclear factor kB in pancreatic cancer cell lines. World J Gastroenterol 14:3672–3680

    Article  CAS  Google Scholar 

  69. Stoner GD, Mukhtar H (1995) Polyphenols as cancer chemopreventive agents. J Cell Biochem 59:169–180

    Article  Google Scholar 

  70. Maas JL, Galletta GJ, Stoner GD (1991) Ellagic acid, an anticarcinogen in fruits, especially strawberries: a review. HortSci 26:1–14

    Google Scholar 

  71. Ismail T, Calcabrini C, Diaz RA, Fimognari C, Turrini E, Catanzaro E, Akhtar S, Sestili P (2016) Ellagitannins in cancer chemoprevention and therapy. Toxins 8:1–22. https://doi.org/10.3390/toxins8050151

    Article  CAS  Google Scholar 

  72. Kasimsetty SG, Bialonska D, Reddy MK, Ma G, Khan SI, Ferreira D (2010) Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. J Agric Food Chem 58:2180–2187

    Article  CAS  Google Scholar 

  73. Heber D (2008) Multitargeted therapy of cancer by ellagitannins. Cancer Lett 269:262–268

    Article  CAS  Google Scholar 

  74. Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D (2005) In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 16:360–367

    Article  CAS  Google Scholar 

  75. Lu Y, Jiang F, Jiang H, Wu K, Zheng W, Yizhong C, Katakowski M, Chopp M, To S-ST (2010) Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. Eur J Pharmacol 641:102–117

    Article  CAS  Google Scholar 

  76. Kaur M, Velmurugan B, Rajamankckam S, Agarwal R, Agarwal C (2009) Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude cell. Pharm Res 25:213–2140

    Google Scholar 

  77. Verma S, Sing A, Mishra A (2013) Gallic acid: molecular rival of cancer. Enviorn Toxicol Pharmacol 35:473–485

    Article  CAS  Google Scholar 

  78. Ho H-H, Chang C-S, Ho W-C, Liao S-Y, Wu C-H, Wang C-J (2010) Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals. Food ChemToxicol 48:2508–2516

    Article  CAS  Google Scholar 

  79. Toth M, Sohail A, Fridman R (2012) Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography. Methos Mol Biol 878:121–135

    Article  CAS  Google Scholar 

  80. Locatelli C, Filippin-Monteiro FB, Creczynski-Pasa TB (2013) Alkyl ester of gallic acid as anticancer agents: a review. Eur J Med Chem 60:233–239

    Article  CAS  Google Scholar 

  81. Kong J-M, Chia L-S, Goh N-K, Chia T-F, Brouillard R (2003) Analysis and biological activities of anthocyanins. Phytochemistry 64:923–933

    Article  CAS  Google Scholar 

  82. Zhang Y, Vareed SK, Nair MG (2005) Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci 76:1465–1472

    Article  CAS  Google Scholar 

  83. Feng R, Ni H-M, Wang SY, Tourkova IL, Shurin MR, Harada H, Yin X-M (2007) Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J Biol Chem 282:13468–13476

    Article  CAS  Google Scholar 

  84. Brandstetter H, Grams F, Glitz D, Lang A, Huber R, Bode W, Krell H-W, Engh RA (2001) The 1.8-Å crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition. J Biol Chem 276:17405–17412

    Article  CAS  Google Scholar 

  85. Nagase H, Sasaki K, Kito H, Haga A, Sato T (1998) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro. Planta Med 64:216–219

    Article  CAS  Google Scholar 

  86. Bagchi D, Sen C, Bagchi M, Atalay M (2004) Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemist 69:75–80

    CAS  Google Scholar 

  87. Wang L-S, Stoner GD (2008) Anthocyanins and their role in cancer prevention. Cancer Lett 269:281–290

    Article  CAS  Google Scholar 

  88. Libby P, Sukhova G, Lee RT, Liao JK (1997) Molecular biology of atherosclerosis. Int J Cardiol 62:S23–S29

    Article  Google Scholar 

  89. Libby P (2012) Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 32:2045–2051

    Article  CAS  Google Scholar 

  90. Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH (2009) Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse. Atherosclerosis 204:147–155

    Article  CAS  Google Scholar 

  91. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL (1996) The Yin and Yang of oxidation in the development of the fatty streak. Arterioscler Thromb Vasc Biol 16:831–842

    Article  CAS  Google Scholar 

  92. Aviram M (1993) Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 98:1–9

    Article  CAS  Google Scholar 

  93. Wang HX, Ng TB (1999) Natural products with hyperglycemic hypertensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities. Life Sci 65(25):2663–2677

    Article  CAS  Google Scholar 

  94. Batista ÂG, Lenquiste SA, Moldenhauer C, Gody JT, Pissini MR, Maróstica MR Jr (2013) Jaboticaba (Myrciaria jaboticaba (Vell.) Berg) peel improved triglyceride excretion and hepatic lipid peroxidation in high fat fed rats. Rev Nutr 5:571–581

    Article  Google Scholar 

  95. Alezandro MR, Granato D, Genovese MI (2013) Jaboticaba (Myrciaria jaboticaba (Vell.) Berg), a Brazilian grape-like fruit, improves lipid profile in streptozotocin-mediated oxidative stress in diabetic rats. Food Res Int 54:650–659

    Article  CAS  Google Scholar 

  96. German JB, Dillard CJ (2004) Saturated fats: what dietary intake?1,2,3. Am J Clin Nutr 80:550–559

    Article  CAS  Google Scholar 

  97. Chang W-C, Yu Y-M, Chiang S-Y, Tseng C-Y (2008) Ellagic acid suppresses oxidised low-density lipoprotein-induced aortic smooth muscle cell proliferation: studies on the activation of extracellular signal-regulated kinase 1/2 and proliferating cell nuclear antigen expression. Br J Nutr 99:709–714

    Article  CAS  Google Scholar 

  98. Papoutsi Z, Kassi E, Chinou I, Halabalaki M, Skaltsounis L, Moutsatsou P (2008) Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr 99:715–722

    Article  CAS  Google Scholar 

  99. Yu Y-M, Wang Z-H, Liu C-H, Chen C-S (2007) Ellagic acid inhibits IL-1β-induced cell adhesion molecule expression in human umbilical vein endothelial cells. Br J Nutr 97:692–698

    Article  CAS  Google Scholar 

  100. Chen XP, Zhang TT, Du GH (2007) Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis. Cardiovas Drug Rev 25:146–161

    Article  CAS  Google Scholar 

  101. Lee W-J, Ou H-C, Hsu W-C, Chou M-M, Tseng J-J, Hsu S-L, Tsai K-L, Sheu WH-H (2010) Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation and inflammation in human endothelial cells. J Vasc Surg 52:1290–1300

    Article  Google Scholar 

  102. Zou M-H, Leist M, Ullrich V (1999) Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries. Am J Pathol 154:1359–1365

    Article  CAS  Google Scholar 

  103. Larrosa M, García-Conesa MT, Espín JC, Tomás-Barberán FA (2010) Ellagitannins, ellagic acid and vascular health. Mol Asp Med 31:513–539

    Article  CAS  Google Scholar 

  104. Xia X, Ling W, Ma J, Xia M, Hou M, Wang Q, Zhu H, Tang Z (2006) An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein E–deficient mice. J Nutr 136:2220–2225

    Article  CAS  Google Scholar 

  105. de Pascual-Teresa S, Moreno DA, García-Viguera C (2010) Flavanols and anthocyanins in cardiovascular health: a review of current evidence. Int J Mol Sci 11:1679–1703

    Article  CAS  Google Scholar 

  106. Wallace TC (2011) Anthocyanins in cardiovascular disease. Adv Cardiovasc Dis 2:1–7

    CAS  Google Scholar 

  107. Morton LW, Caccetta RAA, Puddy IB, Croft KD (2000) Chemistry and biological effect of dietary phenolic compounds: relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 27:152–159

    Article  CAS  Google Scholar 

  108. Kritchevsky D, Story JA (1978) Fiber hypercholesteremia and atherosclerosis. Lipids 13:366–369

    Article  CAS  Google Scholar 

  109. Glore SR, Treeck DV, Knehans AW, Guild M (1994) Soluble fiber and serum lipids: a literature review. J Am Diet Assoc 94:425–436

    Article  CAS  Google Scholar 

  110. Leveille GA, Sauberlich HE (1966) Mechanism of the cholesterol depressing effect of pectin in the cholesterol fed rat. J Nutr 88:209–214

    Article  CAS  Google Scholar 

  111. Diamant M, Black EE, de Vos WM (2011) Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obes Rev 12:272–281

    Article  CAS  Google Scholar 

  112. Collins MD, Gibson GR (1999) Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr 69:1052S–1057S

    Article  CAS  Google Scholar 

  113. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity- associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031

    Article  Google Scholar 

  114. Roberfroid MB (2001) Prebiotics: preferential substrates for specific germs? Am J Clin Nutr 73:406S–409S

    Article  CAS  Google Scholar 

  115. Gonzalez-Barrio R, Pilar Truchado P, Hideyuki I, Espín JC, Tomas-Barberan FA (2011) UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals. J Agric Food Chem 59:1152–1162

    Article  CAS  Google Scholar 

  116. Faria A, Fernandes I, Norberto S, Mateus N, Calhau C (2014) Interplay between anthocyanins and gut microbiota. J Agric Food Chem 62:6969–6902

    Article  CAS  Google Scholar 

  117. Okuda T, Yoshida T, Hatano T (1989) New methods of analyzing tannins. J Nat Prod 52:1–31

    Article  CAS  Google Scholar 

  118. Mertens-Talcott SU, Jilma-Stohlawetz P, Rios J, Hingorani L, Derendorf H (2006) Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food Chem 54:8956–8961

    Article  CAS  Google Scholar 

  119. Selma MV, Romo-Vaquero M, García-Villalba R, González-Sarrías A, Tomás-Barberán FA, Espín JC (2016) The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism. Food Funct 7:1769–1774

    Article  CAS  Google Scholar 

  120. Selma MV, Tomás-Barberán FA, Beltran D, García-Villalba R, Espín JC (2014) Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut. Int J Syst Evol Microbiol 64:2346–2352

    Article  CAS  Google Scholar 

  121. Li Z, Henning SM, Lee RP, Lu Q-Y, Summanen PH, Thames G, Corbett K, Downes J, Tseng C-H, Finegold SM (2015) Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct 6:2487–2495

    Article  CAS  Google Scholar 

  122. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP (2009) A core gut microbiome in obese and lean twins. Nature 457:480–484

    Article  CAS  Google Scholar 

  123. Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444:1022–1023

    Article  CAS  Google Scholar 

  124. Williamson G, Clifford MN (2010) Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 104:S48–S66

    Article  CAS  Google Scholar 

  125. Hidalgo M, Oruna-Concha MJ, Kolida S, Walton GE, Kallithraka S, Spencer JP, de Pascual-Teresa S (2012) Metabolism of anthocyanins by human gut microflora and their influence. J Agric Food Chem 60:3882–3890

    Article  CAS  Google Scholar 

  126. Gibson GR (1998) Dietary modulation of the human gut microflora using prebiotics. Br J Nutr 80:S209–S212

    CAS  Google Scholar 

  127. Jiang T, Gao X, Wu C, Tian F, Lei Q, Bi J, Xie B, Wang HY, Chen S, Wang X (2016) Apple-derived pectin modulates gut microbiota, improves gut barrier function, and attenuates metabolic endotoxemia in rats with diet induced obesity. Nutrients 8:126. https://doi.org/10.3390/nu8030126

    Article  CAS  Google Scholar 

  128. Parkar SG, Redgat EL, Wibisono R, Luo X, Koh ETH, Roswitha Schroder R (2010) Gut health benefits of kiwifruit pectins: comparison with commercial functional polysaccharides. J Funct Foods 2:210–218

    Article  CAS  Google Scholar 

  129. Nazzaro F, Fratianni F, Nicolaus B, Poli A, Orlando P (2010) The prebiotic source influences the growth, biochemical features and survival under simulate gastrointestinal conditions of the prebiotic Lactobacillus acidophilus. Anaerobe 18:280–285

    Article  CAS  Google Scholar 

  130. Hopps E, Noto D, Caimi G, Averna MR (2010) A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis 20:72–77

    Article  CAS  Google Scholar 

  131. Eckel RH, Grandy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365:1415–1428

    Article  CAS  Google Scholar 

  132. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordan RMK, Savage PJ, Smith SC, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome. Circulation 12:2735–2752

    Article  Google Scholar 

  133. World Health Organization (2000) Obesity: preventing and managing the global epidemic. Defining the problem, who library cataloging in publication data. Technical report series, vol 894. WHO, Geneva, pp 1–13

    Google Scholar 

  134. Vincent HK, Innes KE, Vincent KR (2007) Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 9:813–839

    Article  CAS  Google Scholar 

  135. Dragano NR, Cintra DE, Solon C, Morari J, Leite-Legatti AV, Velloso LA, Maróstica-Jr MR (2013) Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat- fed mice. Br J Nutr 110:447–455

    Article  CAS  Google Scholar 

  136. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782–787

    Article  CAS  Google Scholar 

  137. Lenquiste SA, Batista ÂG, da Silva MR, Dragano NRV, Maróstica MR (2012) Freeze-dried jaboticaba peel added to high-fat diet increases HDL-cholesterol and improves insulin resistance in obese rats. Food Res Int 49:153–160

    Article  CAS  Google Scholar 

  138. Matsukawa T, Villareal MO, Isoda H (2016) The type 2 diabetes-preventive effect of cyanidin-3-glucoside on adipocytes. J Dev Sustain Agri 11:31–35

    Google Scholar 

  139. Garcia-Diaz DF, Johnson MH, de Mejia EG (2014) Anthocyanins from fermented berry beverages inhibit inflammation related adiposity response in vitro. J Med Med 18:489–496

    Google Scholar 

  140. Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR (2008) Whole berries versus berry anthocyanins: interactions with dietary fat levels in C5&7BL/6J mouse model of obesity. J Agric Food Chem 56:647–653

    Article  CAS  Google Scholar 

  141. Tsuda T (2008) Regulation of adipocyte function by anthocyanins, possibility of preventing the metabolic syndrome. J Agric Food Chem 56:642–646

    Article  CAS  Google Scholar 

  142. Sancho RAS, Pastore GM (2012) Evaluation of the effects of anthocyanins in type 2 diabetes. Food Res Int 46:378–386

    Article  CAS  Google Scholar 

  143. Al-Muammar MN, Kahn F (2012) Obesity: the preventive role of the pomegranate (Punica granatum). Nutrition 28:595–604

    Article  CAS  Google Scholar 

  144. Bigliardi B, Galati F (2013) Innovation trends in the food industry: the case of functional foods. Trends Food Sci Technol 31:118–129

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas, Brazil

    Natália Crialeison Balbo Vall Ribeiro & Andressa Mara Baseggio

  2. Department of Food Science and Technology, University of Nebraska Lincoln, Lincoln, NE, USA

    Vicki Schlegel

Authors
  1. Natália Crialeison Balbo Vall Ribeiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andressa Mara Baseggio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vicki Schlegel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vicki Schlegel .

Editor information

Editors and Affiliations

  1. Gr. d'Etude Subst. Vég. à Act. Biol, Institut des Sciences de la Vigne e Gr. d'Etude Subst. Vég. à Act. Biol, Villenave d'Ornon, France

    Jean-Michel Mérillon

  2. M.L. Sukhadia University , Badgaon, Rajasthan, India

    K.G. Ramawat

Rights and permissions

Reprints and permissions

Copyright information

© 2018 This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Ribeiro, N.C.B.V., Baseggio, A.M., Schlegel, V. (2018). Jaboticaba: Chemistry and Bioactivity. In: Mérillon, JM., Ramawat, K. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-54528-8_24-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-54528-8_24-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54528-8

  • Online ISBN: 978-3-319-54528-8

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

Publish with us

Policies and ethics

Search

Navigation