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Alkaloid

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Alkaloids are cyclic compounds containing nitrogen in a negative oxidation state which is of limited distribution in a living organism. The term “alkaloid” marks its origin from the word “alkaline” which in Arabic means “ashes of plants.” They are generally known to be plant metabolites but are also produced by bacteria, fungi, and animals (Clark and Hufford 1992). Presently, more than 5,500 alkaloids are known and are highly placed with respect to their diversity, efficiency, and therapeutic significance. Research shows that almost 20% of the plants produce alkaloids and their major source in the flowering plants is the angiosperm (Pelletier 1983). Being toxic in nature, their main role in plants is to defend them against the micro-organisms, insects, and herbivores.

Chemically, they are a class of natural compounds, majority of which contain nitrogen and a few of them being non-nitrogen heterocyclic organic amines. Mostly, basic in nature but these compounds can also range from being...

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Reference

  • Bienz, S., Bisegger, P., Guggisberg, A., & Hesse, M. (2005). Polyamine alkaloids. Natural Product Reports, 22, 647–658.

    Article  Google Scholar 

  • Caron, C., Hoizey, M. J., Le Men-Olivier, L., Massiot, G., Zeches, M., Choisy, C., et al. (1988). Antimicrobial and antifungal activities of quasi-dimeric and related alkaloids. Planta Medica, 54, 409–412.

    Article  Google Scholar 

  • Clark, A. M., & Hufford, C. D. (1992). Antifungal alkaloids. In The alkaloids: Chemistry and pharmacology (Vol. 42, pp. 117–150). New York: Academic.

    Google Scholar 

  • Dewick, P. M. (2002). Medicinal natural products: A biosynthetic approach. Chichester/New York: Wiley.

    Google Scholar 

  • Dupont, C., Couillerot, E., Gillet, R., Caron, C., Zeches-Hanrot, M., Riou, J. F., & Trentesaux, C. (2005). The benzophenanthridine alkaloid fagaronine induces erythroleukemic cell differentiation by gene activation. Planta Medica, 71, 489–494.

    Article  Google Scholar 

  • Gournelis, D. C., Laskaris, G. G., & Verpoorte, R. (1997). Cyclopeptide alkaloids. Natural Product Reports, 14(1), 75–82.

    Article  Google Scholar 

  • Lewis, R. A. (1998). Lewis’ dictionary of toxicology. Boca Raton: CRC press.

    Google Scholar 

  • Manske, R. H. F., & Holmes, H. L. (Eds.). (2014). The alkaloids: Chemistry and physiology. Burlington: Elsevier.

    Google Scholar 

  • Matolcsy, G., Nádasy, M., & Andriska, V. (1988). Pesticide chemistry (Vol. 32). Amsterdam: Elsevier.

    Google Scholar 

  • McNaught, A. D., & Wilkinson, A. (1997). Compendium of chemical terminology (Vol. 1669). Oxford: Blackwell Science.

    Google Scholar 

  • Nazrullaev, S. S., Bessonova, I. A., & Akhmedkhodzhaeva, K. S. (2001). Estrogenic activity as a function of chemical structure in Haplophyllum quinoline alkaloids. Chemistry of Natural Compounds, 37, 551–555.

    Article  Google Scholar 

  • Pelletier, S. W. (1983). The nature and definition of an alkaloid. Alkaloids: Chemical and Biological Perspectives, 1, 1–31.

    Google Scholar 

  • Plemenkov, V. V. (2001). Introduction to the chemistry of natural compounds (p. 242). Kazan.

    Google Scholar 

  • Singh, A. K., Pandey, M. B., & Singh, U. P. (2007). Antifungal activity of an alkaloid allosecurinine against some fungi. Mycobiology, 35, 62–64.

    Article  Google Scholar 

  • Tadeusz, A. (2007). Alkaloids–secrets of life: Alkaloid chemistry, biological significance, applications and ecological role. Amsterdam: Elsevier.

    Google Scholar 

  • Tuenter, E., Segers, K., Kang, K. B., Viaene, J., Sung, S. H., Cos, P., et al. (2017). Antiplasmodial activity, cytotoxicity and structure-activity relationship study of Cyclopeptide alkaloids. Molecules, 22, 224.

    Article  Google Scholar 

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Neelabh (2019). Alkaloid. In: Vonk, J., Shackelford, T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-47829-6_218-1

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  • DOI: https://doi.org/10.1007/978-3-319-47829-6_218-1

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  • Print ISBN: 978-3-319-47829-6

  • Online ISBN: 978-3-319-47829-6

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