Synonyms
Definition
An RNA sequence not coding for a protein is termed as a noncoding (nc) RNA.
Introduction
In general, the term noncoding RNA is used for RNA sequences that get transcribed from DNA but do not code for a protein. However, this does not imply that these RNAs do not code for any information or are devoid of any function. Studies have shown that the genome of mammals and other higher organisms gets transcribed into noncoding RNAs, which further undergo the process of splicing, leading to smaller products. The field of noncoding RNAs has progressed a great deal in the past decade due to the development of high-throughput sequencing tools and bioinformatic software (Delpu et al. 2016; https://www.whatisepigenetics.com/non-coding-rna/).
It is fascinating to know that a large chunk of the total RNA (around 60%) belongs to the class of noncoding RNAs. The functions of the noncoding RNAs involving complex mechanisms are gradually being understood. More or less, the...
References
Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W. J., Mattick, J. S., & Haussler, D. (2004). Ultraconserved elements in the human genome. Science, 5675, 1321–1325.
Calin, G. A., Liu, C. G., Ferracin, M., Hyslop, T., Spizzo, R., Sevignani, C., et al. (2007). Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell, 12, 215–229.
Carmichael, G. G. (2003). Antisense starts making more sense. Nature Biotechnology, 21, 371–372.
Delpu, Y., Larrieu, D., Gayral, M., Arvanitis, D., Dufresne, M., Cordelier, P., & Torrisani, J. (2016). Noncoding RNAs: Clinical and therapeutic applications. In G. Egger & P. Arimondo (Eds.), Drug discovery in cancer epigenetics (pp. 305–326). Boston, Academic.
Esteller, M. (2011). Non-coding RNAs in human disease. Nature Reviews Genetics, 12, 861.
Henry, R. W., Mittal, V., Ma, B., Kobayashi, R., & Hernandez, N. (1998). SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. Genes & Development, 12, 2664–2672.
Ishizu, H., Siomi, H., & Siomi, M. C. (2012). Biology of PIWI-interacting RNAs: New insights into biogenesis and function inside and outside of germlines. Genes & Development, 26, 2361–2373.
Iwasaki, Y. W., Siomi, M. C., & Siomi, H. (2015). PIWI-interacting RNA: Its biogenesis and functions. Annual Review of Biochemistry, 84, 405–433.
King, T. H., Liu, B., McCully, R. R., & Fournier, M. J. (2003). Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center. Molecular Cell, 11, 425–435.
Kiss-László, Z., Henry, Y., Bachellerie, J. P., Caizergues-Ferrer, M., & Kiss, T. (1996). Site-specific ribose methylation of preribosomal RNA: A novel function for small nucleolar RNAs. Cell, 85, 1077–1088.
Lavorgna, G., Dahary, D., Lehner, B., Sorek, R., Sanderson, C. M., & Casari, G. (2004). In search of antisense. Trends in Biochemical Sciences, 29, 88–94.
Mestdagh, P., Fredlund, E., Pattyn, F., Rihani, A., Van Maerken, T., Vermeulen, J., et al. (2010). An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours. Oncogene, 29, 3583.
Ni, J., Tien, A. L., & Fournier, M. J. (1997). Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA. Cell, 89, 565–573.
Osato, N., Suzuki, Y., Ikeo, K., & Gojobori, T. (2007). Transcriptional interferences in cis natural antisense transcripts of humans and mice. Genetics, 176, 1299–1306.
Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W. J., & Pandolfi, P. P. (2010). A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature, 465, 1033.
Saey, T. H. (2011). Missing lincs: Lesser-known genetic material helps explain why humans are human. Science News, 180, 22–25.
Sasidharan, R., & Gerstein, M. (2008). Genomics: Protein fossils live on as RNA. Nature, 453, 729.
Vanhée-Brossollet, C., & Vaquero, C. (1998). Do natural antisense transcripts make sense in eukaryotes? Gene, 211, 1–9.
Wang, X. J., Gaasterland, T., & Chua, N. H. (2005). Genome-wide prediction and identification of cis-natural antisense transcripts in Arabidopsis thaliana. Genome Biology, 6, R30.
Zhang, Y., Liu, X. S., Liu, Q. R., & Wei, L. (2006). Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species. Nucleic Acids Research, 34, 3465–3475.
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Neelabh, N., Gautam, A. (2018). Noncoding RNA. In: Vonk, J., Shackelford, T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-47829-6_192-1
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DOI: https://doi.org/10.1007/978-3-319-47829-6_192-1
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