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Surveillance and Follow-Up of Melanoma Patients

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Cutaneous Melanoma

Abstract

The patient treated for melanoma lives with some risk of recurrence and needs a rational plan for posttreatment follow-up. Appropriate follow-up for melanoma survivors must balance the benefits and harms of repeated surveillance with the needs and goals of the patient and within the capacity and constraints of the healthcare system in which the follow-up occurs.

Routine surveillance by a clinician is an important aspect of follow-up for detection of melanoma recurrence. For decades, attempts have been made to introduce a follow-up schedule that would find international consensus, but to date, there is no consensus on the optimal frequency, intensity, and duration of follow-up in melanoma patients. Dermatologic surveillance is important for detecting new primary and other non­melanoma skin cancers in this group of patients, a group that frequently has a history of sun damage. A whole-body examination by an experienced dermatologist using technical instruments such as dermoscopy remains the gold standard. During routine follow-up by a healthcare professional, in addition to dermatological examination, a range of strategies including radiologic and laboratory tests are  often used. However, there is little evidence to support the value of routine radiologic and laboratory testing particularly in the follow-up of stage I/II melanoma patients.

In addition to visits with a healthcare provider, skin self-examination is recommended to identify primary cutaneous lesions but also for detection of recurrences in the locoregional area. Follow-up clinics and guidelines in melanoma care exist around the world. However, the evidence to date is insufficient to strongly support one specific set of follow-up guidelines. This chapter outlines the principles and components of follow-up care.

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References

  • Argenziano G (2005) The impact of dermoscopy on the management of pigmented skin lesions: the role of follow-up. J Am Acad Dermatol 52:178; author reply 179–180

    Article  PubMed  Google Scholar 

  • Australian Institute for Health and Welfare (AIHW) (2018) Melanoma skin cancer in Australia [Online]. https://melanoma.canceraustralia.gov.au/statistics. Accessed Aug 2018

  • Bafounta ML, Beauchet A, Chagnon S, Saiag P (2004) Ultrasonography or palpation for detection of melanoma nodal invasion: a meta-analysis. Lancet Oncol 5:673–680

    Article  PubMed  Google Scholar 

  • Balch CM, Soong SJ, Smith T, Ross MI, Urist MM, Karakousis CP, Temple WJ, Mihm MC, Barnhill RL, Jewell WR, Wanebo HJ, Desmond R, Investigators from the Intergroup Melanoma Surgical, T (2001) Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1–4 mm melanomas. Ann Surg Oncol 8:101–108

    CAS  PubMed  Google Scholar 

  • Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, Mcmasters KM, Mihm MC Jr, Morton DL, Ross MI, Sober AJ, Sondak VK (2009) Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 27:6199–6206

    Article  PubMed  PubMed Central  Google Scholar 

  • Basseres N, Grob JJ, Richard MA, Thirion X, Zarour H, Noe C, Collet-Vilette AM, Lota I, Bonerandi JJ (1995) Cost-effectiveness of surveillance of stage I melanoma. A retrospective appraisal based on a 10-year experience in a dermatology department in France. Dermatology 191:199–203

    Article  CAS  PubMed  Google Scholar 

  • Baughan CA, Hall VL, Leppard BJ, Perkins PJ (1993) Follow-up in stage I cutaneous malignant melanoma: an audit. Clin Oncol (R Coll Radiol) 5:174–180

    Article  CAS  Google Scholar 

  • Bell KJL, Mehta Y, Turner RM, Morton RL, Dieng M, Saw R, Guitera P, Mccaffery K, Low D, Low C, Jenkins M, Irwig L, Webster AC (2017) Fear of new or recurrent melanoma after treatment for localised melanoma. Psychooncology 26:1784–1791

    Article  PubMed  Google Scholar 

  • Binder M, Puespoeck-Schwarz M, Steiner A, Kittler H, Muellner M, Wolff K, Pehamberger H (1997) Epiluminescence microscopy of small pigmented skin lesions: short-term formal training improves the diagnostic performance of dermatologists. J Am Acad Dermatol 36:197–202

    Article  CAS  PubMed  Google Scholar 

  • Boesen EH, Ross L, Frederiksen K, Thomsen BL, Dahlstrom K, Schmidt G, Naested J, Krag C, Johansen C (2005) Psychoeducational intervention for patients with cutaneous malignant melanoma: a replication study. J Clin Oncol 23:1270–1277

    Article  PubMed  Google Scholar 

  • Borgstein PJ, Meijer S, Van Diest PJ (1999) Are locoregional cutaneous metastases in melanoma predictable? Ann Surg Oncol 6:315–321

    Article  CAS  PubMed  Google Scholar 

  • Borsari S, Pampena R, Lallas A, Kyrgidis A, Moscarella E, Benati E, Raucci M, Pellacani G, Zalaudek I, Argenziano G, Longo C (2016) Clinical indications for use of reflectance confocal microscopy for skin cancer diagnosis. JAMA Dermatol 152:1093–1098

    Article  PubMed  Google Scholar 

  • Bradford PT, Freedman DM, Goldstein AM, Tucker MA (2010) Increased risk of second primary cancers after a diagnosis of melanoma. Arch Dermatol 146:265–272

    Article  PubMed  PubMed Central  Google Scholar 

  • Brandberg Y, Mansson-Brahme E, Ringborg U, Sjoden PO (1995) Psychological reactions in patients with malignant melanoma. Eur J Cancer 31A:157–162

    Article  CAS  PubMed  Google Scholar 

  • Brown RE, Stromberg AJ, Hagendoorn LJ, Hulsewede DY, Ross MI, Noyes RD, Goydos JS, Urist MM, Edwards MJ, Scoggins CR, Mcmasters KM, Martin RC 2nd (2010) Surveillance after surgical treatment of melanoma: futility of routine chest radiography. Surgery 148:711–716; discussion 716–717

    Article  PubMed  Google Scholar 

  • Cancer Council Australia (2018) Clinical practice guidelines for the diagnosis and management of melanoma [Online]. https://wiki.cancer.org.au/australia/Guidelines:Melanoma

  • Chao C, Wong SL, Ross MI, Reintgen DS, Noyes RD, Cerrito PB, Edwards MJ, Mcmasters KM, Sunbelt Melanoma Trial, G (2002) Patterns of early recurrence after sentinel lymph node biopsy for melanoma. Am J Surg 184:520–524; discussion 525

    Article  PubMed  Google Scholar 

  • Cohn-Cedermark G, Rutqvist LE, Andersson R, Breivald M, Ingvar C, Johansson H, Jonsson PE, Krysander L, Lindholm C, Ringborg U (2000) Long term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8–2.0 mm. Cancer 89:1495–1501

    Article  CAS  PubMed  Google Scholar 

  • Cromwell KD, Ross MI, Xing Y, Gershenwald JE, Royal RE, Lucci A, Lee JE, Cormier JN (2012) Variability in melanoma post-treatment surveillance practices by country and physician specialty: a systematic review. Melanoma Res 22:376–385

    Article  PubMed  Google Scholar 

  • Dalal KM, Patel A, Brady MS, Jaques DP, Coit DG (2007) Patterns of first-recurrence and post-recurrence survival in patients with primary cutaneous melanoma after sentinel lymph node biopsy. Ann Surg Oncol 14:1934–1942

    Article  PubMed  Google Scholar 

  • Dalle S, Paulin C, Lapras V, Balme B, Ronger-Savle S, Thomas L (2006) Fine-needle aspiration biopsy with ultrasound guidance in patients with malignant melanoma and palpable lymph nodes. Br J Dermatol 155:552–556

    Article  CAS  PubMed  Google Scholar 

  • Damude S, Hoekstra-Weebers JE, Francken AB, Ter Meulen S, Bastiaannet E, Hoekstra HJ (2016) The MELFO-study: prospective, randomized, clinical trial for the evaluation of a stage-adjusted reduced follow-up schedule in cutaneous melanoma patients-results after 1 year. Ann Surg Oncol 23:2762–2771

    Article  PubMed  PubMed Central  Google Scholar 

  • Dancey A, Rayatt S, Courthold J, Roberts J (2005) Views of UK melanoma patients on routine follow-up care. Br J Plast Surg 58:245–250

    Article  CAS  PubMed  Google Scholar 

  • Danielsen M, Hojgaard L, Kjaer A, Fischer BM (2013) Positron emission tomography in the follow-up of cutaneous malignant melanoma patients: a systematic review. Am J Nucl Med Mol Imaging 4:17–28

    PubMed  PubMed Central  Google Scholar 

  • Deichmann M, Benner A, Bock M, Jackel A, Uhl K, Waldmann V, Naher H (1999) S100-Beta, melanoma-inhibiting activity, and lactate dehydrogenase discriminate progressive from nonprogressive American Joint Committee on Cancer stage IV melanoma. J Clin Oncol 17:1891–1896

    Article  CAS  PubMed  Google Scholar 

  • Dicker TJ, Kavanagh GM, Herd RM, Ahmad T, Mclaren KM, Chetty U, Hunter JA (1999) A rational approach to melanoma follow-up in patients with primary cutaneous melanoma. Scottish Melanoma Group. Br J Dermatol 140:249–254

    Article  CAS  PubMed  Google Scholar 

  • Dieng M, Butow PN, Costa DS, Morton RL, Menzies SW, Mireskandari S, Tesson S, Mann GJ, Cust AE, Kasparian NA (2016) Psychoeducational intervention to reduce fear of cancer recurrence in people at high risk of developing another primary melanoma: results of a randomized controlled trial. J Clin Oncol 34:4405–4414

    Article  PubMed  Google Scholar 

  • Faries MB, Morton DL (2006) The promise of metastasectomy in melanoma. Ann Surg Oncol 13:607–609

    Article  PubMed  Google Scholar 

  • Faries MB, Steen S, Ye X, Sim M, Morton DL (2013) Late recurrence in melanoma: clinical implications of lost dormancy. J Am Coll Surg 217:27–34; discussion 34–36

    Article  PubMed  PubMed Central  Google Scholar 

  • Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters M, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, Mackenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, Mcmasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, Mckinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM (2017) Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med 376:2211–2222

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferrone CR, Ben Porat L, Panageas KS, Berwick M, Halpern AC, Patel A, Coit DG (2005) Clinicopathological features of and risk factors for multiple primary melanomas. JAMA 294:1647–1654

    Article  CAS  PubMed  Google Scholar 

  • Fields RC, Coit DG (2011) Evidence-based follow-up for the patient with melanoma. Surg Oncol Clin N Am 20:181–200

    Article  PubMed  Google Scholar 

  • Francken AB, Bastiaannet E, Hoekstra HJ (2005) Follow-up in patients with localised primary cutaneous melanoma. Lancet Oncol 6:608–621

    Article  PubMed  Google Scholar 

  • Francken AB, Shaw HM, Accortt NA, Soong SJ, Hoekstra HJ, Thompson JF (2007) Detection of first relapse in cutaneous melanoma patients: implications for the formulation of evidence-based follow-up guidelines. Ann Surg Oncol 14:1924–1933

    Article  PubMed  Google Scholar 

  • Francken AB, Accortt NA, Shaw HM, Colman MH, Wiener M, Soong SJ, Hoekstra HJ, Thompson JF (2008a) Follow-up schedules after treatment for malignant melanoma. Br J Surg 95:1401–1407

    Article  CAS  PubMed  Google Scholar 

  • Francken AB, Shaw HM, Thompson JF (2008b) Detection of second primary cutaneous melanomas. Eur J Surg Oncol 34:587–592

    Article  CAS  PubMed  Google Scholar 

  • Fusi S, Ariyan S, Sternlicht A (1993) Data on first recurrence after treatment for malignant melanoma in a large patient population. Plast Reconstr Surg 91:94–98

    Article  CAS  PubMed  Google Scholar 

  • Gadd MA, Coit DG (1992) Recurrence patterns and outcome in 1019 patients undergoing axillary or inguinal lymphadenectomy for melanoma. Arch Surg 127:1412–1416

    Article  CAS  PubMed  Google Scholar 

  • Garbe C, Paul A, Kohler-Spath H, Ellwanger U, Stroebel W, Schwarz M, Schlagenhauff B, Meier F, Schittek B, Blaheta HJ, Blum A, Rassner G (2003) Prospective evaluation of a follow-up schedule in cutaneous melanoma patients: recommendations for an effective follow-up strategy. J Clin Oncol 21:520–529

    Article  PubMed  Google Scholar 

  • Garbe C, Hauschild A, Volkenandt M, Schadendorf D, Stolz W, Reinhold U, Kortmann RD, Kettelhack C, Frerich B, Keilholz U, Dummer R, Sebastian G, Tilgen W, Schuler G, Mackensen A, Kaufmann R (2007) Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma. Melanoma Res 17:393–399

    Article  PubMed  Google Scholar 

  • Gershenwald JE, Colome MI, Lee JE, Mansfield PF, Tseng C, Lee JJ, Balch CM, Ross MI (1998) Patterns of recurrence following a negative sentinel lymph node biopsy in 243 patients with stage I or II melanoma. J Clin Oncol 16:2253–2260

    Article  CAS  PubMed  Google Scholar 

  • Gershenwald JE, Berman RS, Porter G, Mansfield PF, Lee JE, Ross MI (2000) Regional nodal basin control is not compromised by previous sentinel lymph node biopsy in patients with melanoma. Ann Surg Oncol 7:226–231

    Article  CAS  PubMed  Google Scholar 

  • Green AC, Baade P, Coory M, Aitken JF, Smithers M (2012) Population-based 20-year survival among people diagnosed with thin melanomas in Queensland, Australia. J Clin Oncol 30:1462–1467

    Article  PubMed  Google Scholar 

  • Guitera P, Menzies SW, Argenziano G, Longo C, Losi A, Drummond M, Scolyer RA, Pellacani G (2016) Dermoscopy and in vivo confocal microscopy are complementary techniques for diagnosis of difficult amelanotic and light-coloured skin lesions. Br J Dermatol 175:1311–1319

    Article  CAS  PubMed  Google Scholar 

  • Hansson J, Bergenmar M, Hofer PA, Lundell G, Mansson-Brahme E, Ringborg U, Synnerstad I, Bratel AT, Wennberg AM, Rosdahl I (2007) Monitoring of kindreds with hereditary predisposition for cutaneous melanoma and dysplastic nevus syndrome: results of a Swedish preventive program. J Clin Oncol 25:2819–2824

    Article  PubMed  Google Scholar 

  • Hengge UR, Wallerand A, Stutzki A, Kockel N (2007) Cost-effectiveness of reduced follow-up in malignant melanoma. J Dtsch Dermatol Ges 5:898–907

    Article  PubMed  Google Scholar 

  • Hoffman BR, Katsaros D, Scorilas A, Diamandis P, Fracchioli S, Rigault De La Longrais IA, Colgan T, Puopolo M, Giardina G, Massobrio M, Diamandis EP (2002) Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker. Br J Cancer 87:763–771

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hofmann U, Szedlak M, Rittgen W, Jung EG, Schadendorf D (2002) Primary staging and follow-up in melanoma patients – monocenter evaluation of methods, costs and patient survival. Br J Cancer 87:151–157

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huibertse LJ, Van Eenbergen M, De Rooij BH, Bastiaens MT, Fossion LM, De La Fuente RB, Kil PJ, Koldewijn EL, Meier AH, Mommers RJ, Niemer AQ, Oddens JR, Oomens EH, Prins M, De Roos KP, Thissen MR, Timmermans MW, Wijsman BP, Van De Poll-Franse LV, Ezendam NP (2017) Cancer survivors’ preference for follow-up care providers: a cross-sectional study from the population-based PROFILES-registry. Acta Oncol 56:278–287

    Article  PubMed  Google Scholar 

  • Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J Clin 58:71–96

    Article  PubMed  Google Scholar 

  • Jochems A, Schouwenburg MG, Leeneman B, Franken MG, Van Den Eertwegh AJ, Haanen JB, Gelderblom H, Uyl-De Groot CA, Aarts MJ, Van Den Berkmortel FW, Blokx WA, Cardous-Ubbink MC, Groenewegen G, De Groot JW, Hospers GA, Kapiteijn E, Koornstra RH, Kruit WH, Louwman MW, Piersma D, Van Rijn RS, Ten Tije AJ, Vreugdenhil G, Wouters MW, Van Der Hoeven JJ (2017) Dutch Melanoma Treatment Registry: quality assurance in the care of patients with metastatic melanoma in the Netherlands. Eur J Cancer 72:156–165

    Article  PubMed  Google Scholar 

  • Jones MS, Torisu-Itakura H, Flaherty DC, Schoellhammer HF, Lee J, Sim MS, Faries MB (2016) Second primary melanoma: risk factors, histopathologic features, survival, and implications for follow-up. Am Surg 82:1009–1013

    PubMed  PubMed Central  Google Scholar 

  • Kasparian NA, Branstrom R, Chang YM, Affleck P, Aspinwall LG, Tibben A, Azizi E, Baron-Epel O, Battistuzzi L, Bruno W, Chan M, Cuellar F, Debniak T, Pjanova D, Ertmanski S, Figl A, Gonzalez M, Hayward NK, Hocevar M, Kanetsky PA, Leachman S, Bergman W, Heisele O, Palmer J, Peric B, Puig S, Schadendorf D, Gruis NA, Newton-Bishop J, Brandberg Y, Melanoma Genetics, C (2012) Skin examination behavior: the role of melanoma history, skin type, psychosocial factors, and region of residence in determining clinical and self-conducted skin examination. Arch Dermatol 148:1142–1151

    Article  PubMed  PubMed Central  Google Scholar 

  • Khayat D, Rixe O, Martin G, Soubrane C, Banzet M, Bazex JA, Lauret P, Verola O, Auclerc G, Harper P, Banzet P, French Group of Research on Malignant, M (2003) Surgical margins in cutaneous melanoma (2 cm versus 5 cm for lesions measuring less than 2.1-mm thick). Cancer 97:1941–1946

    Article  PubMed  Google Scholar 

  • Kittler H, Weitzdorfer R, Pehamberger H, Wolff K, Binder M (2001) Compliance with follow-up and prognosis among patients with thin melanomas. Eur J Cancer 37:1504–1509

    Article  CAS  PubMed  Google Scholar 

  • Krahn G, Kaskel P, Sander S, Waizenhofer PJ, Wortmann S, Leiter U, Peter RU (2001) S100 beta is a more reliable tumor marker in peripheral blood for patients with newly occurred melanoma metastases compared with MIA, albumin and lactate-dehydrogenase. Anticancer Res 21:1311–1316

    CAS  PubMed  Google Scholar 

  • Leiter U, Marghoob AA, Lasithiotakis K, Eigentler TK, Meier F, Meisner C, Garbe C (2009) Costs of the detection of metastases and follow-up examinations in cutaneous melanoma. Melanoma Res 19:50–57

    Article  PubMed  Google Scholar 

  • Lim WY, Morton RL, Turner RM, Jenkins MC, Guitera P, Irwig L, Webster AC, Dieng M, Saw RPM, Low D, Low C, Bell KJL (2018) Patient preferences for follow-up after recent excision of a localized melanoma. JAMA Dermatol 154:420–427

    Article  PubMed  PubMed Central  Google Scholar 

  • Livingstone E, Krajewski C, Eigentler TK, Windemuth-Kieselbach C, Benson S, Elsenbruch S, Hauschild A, Rompel R, Meiss F, Mauerer A, Kahler KC, Dippel E, Mollenhoff K, Kilian K, Mohr P, Utikal J, Schadendorf D (2015) Prospective evaluation of follow-up in melanoma patients in Germany – results of a multicentre and longitudinal study. Eur J Cancer 51:653–667

    Article  CAS  PubMed  Google Scholar 

  • Lo SN, Scolyer RA, Thompson JF (2018) Long-term survival of patients with thin (T1) cutaneous melanomas: a Breslow thickness cut point of 0.8 mm separates higher-risk and lower-risk tumors. Ann Surg Oncol 25:894–902

    Article  PubMed  Google Scholar 

  • Machet L, Nemeth-Normand F, Giraudeau B, Perrinaud A, Tiguemounine J, Ayoub J, Alison D, Vaillant L, Lorette G (2005) Is ultrasound lymph node examination superior to clinical examination in melanoma follow-up? A monocentre cohort study of 373 patients. Br J Dermatol 152:66–70

    Article  CAS  PubMed  Google Scholar 

  • Marciano NJ, Merlin TL, Bessen T, Street JM (2014) To what extent are current guidelines for cutaneous melanoma follow up based on scientific evidence? Int J Clin Pract 68:761–770

    Article  CAS  PubMed  Google Scholar 

  • Mccaul KA, Fritschi L, Baade P, Coory M (2008) The incidence of second primary invasive melanoma in Queensland, 1982–2003. Cancer Causes Control 19:451–458

    Article  PubMed  Google Scholar 

  • Memari N, Hayen A, Bell KJ, Rychetnik L, Morton RL, Mccaffery K, Thompson JF, Irwig L, Turner RM (2015) How often do patients with localized melanoma attend follow-up at a specialist center? Ann Surg Oncol 22(Suppl 3):S1164–S1171

    Article  PubMed  Google Scholar 

  • Meyers MO, Yeh JJ, Frank J, Long P, Deal AM, Amos KD, Ollila DW (2009) Method of detection of initial recurrence of stage II/III cutaneous melanoma: analysis of the utility of follow-up staging. Ann Surg Oncol 16:941–947

    Article  PubMed  Google Scholar 

  • Mills K, Emery J, Lantaff R, Radford M, Pannebakker M, Hall P, Burrows N, Williams K, Saunders CL, Murchie P, Walter FM (2017) Protocol for the melatools skin self-monitoring trial: a phase II randomised controlled trial of an intervention for primary care patients at higher risk of melanoma. BMJ Open 7:e017934

    PubMed  PubMed Central  Google Scholar 

  • Moloney FJ, Guitera P, Coates E, Haass NK, Ho K, Khoury R, O’connell RL, Raudonikis L, Schmid H, Mann GJ, Menzies SW (2014) Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study. JAMA Dermatol 150:819–827

    Article  PubMed  Google Scholar 

  • Moncrieff MD, Gyorki D, Saw R, Spillane AJ, Peach H, Oudit D, Geh J, Dziewulski P, Wilson E, Matteucci P, Pritchard-Jones R, Olofsson Bagge R, Wright FC, Crampton N, Cassell O, Jallali N, Berger A, Kelly J, Hamilton S, Durrani A, Lo S, Paton E, Henderson MA (2018) 1 versus 2-cm excision margins for pT2-pT4 primary cutaneous melanoma (MelMarT): a feasibility study. Ann Surg Oncol 25:2541–2549

    Article  PubMed  PubMed Central  Google Scholar 

  • Mooney MM, Mettlin C, Michalek AM, Petrelli NJ, Kraybill WG (1997) Life-long screening of patients with intermediate-thickness cutaneous melanoma for asymptomatic pulmonary recurrences: a cost-effectiveness analysis. Cancer 80:1052–1064

    Article  CAS  PubMed  Google Scholar 

  • Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Elashoff R, Essner R, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Reintgen DS, Coventry BJ, Glass EC, Wang HJ, Group M (2006) Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med 355:1307–1317

    Article  CAS  PubMed  Google Scholar 

  • Morton RL, Rychetnik L, Mccaffery K, Thompson JF, Irwig L (2013) Patients’ perspectives of long-term follow-up for localised cutaneous melanoma. Eur J Surg Oncol 39:297–303

    Article  CAS  PubMed  Google Scholar 

  • Murchie P, Hannaford PC, Wyke S, Nicolson MC, Campbell NC (2007) Designing an integrated follow-up programme for people treated for cutaneous malignant melanoma: a practical application of the MRC framework for the design and evaluation of complex interventions to improve health. Fam Pract 24:283–292

    Article  PubMed  Google Scholar 

  • Murchie P, Nicolson MC, Hannaford PC, Raja EA, Lee AJ, Campbell NC (2010) Patient satisfaction with GP-led melanoma follow-up: a randomised controlled trial. Br J Cancer 102:1447–1455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murchie P, Allan JL, Brant W, Dennis M, Hall S, Masthoff J, Walter FM, Johnston M (2015) Total skin self-examination at home for people treated for cutaneous melanoma: development and pilot of a digital intervention. BMJ Open 5:e007993

    PubMed  PubMed Central  Google Scholar 

  • Nieweg OE, Kroon BB (2006) The conundrum of follow-up: should it be abandoned? Surg Oncol Clin N Am 15:319–330

    Article  PubMed  Google Scholar 

  • Pflugfelder A, Kochs C, Blum A, Capellaro M, Czeschik C, Dettenborn T, Dill D, Dippel E, Eigentler T, Feyer P, Follmann M, Frerich B, Ganten MK, Gartner J, Gutzmer R, Hassel J, Hauschild A, Hohenberger P, Hubner J, Kaatz M, Kleeberg UR, Kolbl O, Kortmann RD, Krause-Bergmann A, Kurschat P, Leiter U, Link H, Loquai C, Loser C, Mackensen A, Meier F, Mohr P, Mohrle M, Nashan D, Reske S, Rose C, Sander C, Satzger I, Schiller M, Schlemmer HP, Strittmatter G, Sunderkotter C, Swoboda L, Trefzer U, Voltz R, Vordermark D, Weichenthal M, Werner A, Wesselmann S, Weyergraf AJ, Wick W, Garbe C, Schadendorf D, German Dermatological S, Dermatologiccooperative Oncology, G (2013) Malignant melanoma S3-guideline “diagnosis, therapy and follow-up of melanoma”. J Dtsch Dermatol Ges 11(Suppl 6):1–116, 1–126

    PubMed  Google Scholar 

  • Poo-Hwu WJ, Ariyan S, Lamb L, Papac R, Zelterman D, Hu GL, Brown J, Fischer D, Bolognia J, Buzaid AC (1999) Follow-up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma. Cancer 86:2252–2258

    Article  CAS  PubMed  Google Scholar 

  • Read RL, Haydu L, Saw RP, Quinn MJ, Shannon K, Spillane AJ, Stretch JR, Scolyer RA, Thompson JF (2015) In-transit melanoma metastases: incidence, prognosis, and the role of lymphadenectomy. Ann Surg Oncol 22:475–481

    Article  PubMed  Google Scholar 

  • Read RL, Madronio CM, Cust AE, Goumas C, Watts CG, Menzies S, Curtin AM, Mann G, Thompson JF, Morton RL (2018) Follow-up recommendations after diagnosis of primary cutaneous melanoma: a population-based study in New South Wales, Australia. Ann Surg Oncol 25:617–625

    Article  PubMed  Google Scholar 

  • Romano E, Scordo M, Dusza SW, Coit DG, Chapman PB (2010) Site and timing of first relapse in stage III melanoma patients: implications for follow-up guidelines. J Clin Oncol 28:3042–3047

    Article  PubMed  PubMed Central  Google Scholar 

  • Rueth NM, Cromwell KD, Cormier JN (2015) Long-term follow-up for melanoma patients: is there any evidence of a benefit? Surg Oncol Clin N Am 24:359–377

    Article  PubMed  PubMed Central  Google Scholar 

  • Rychetnik L, Mccaffery K, Morton RL, Thompson JF, Menzies SW, Irwig L (2013) Follow-up of early stage melanoma: specialist clinician perspectives on the functions of follow-up and implications for extending follow-up intervals. J Surg Oncol 107:463–468

    Article  PubMed  Google Scholar 

  • Saiag P, Bosquet L, Guillot B, Verola O, Avril MF, Bailly C, Cupissol D, Dalac S, Danino A, Dreno B, Grob JJ, Leccia MT, Renaud-Vilmer C, Negrier S, Societe Francaise De D (2007) Management of adult patients with cutaneous melanoma without distant metastasis. 2005 update of the French Standards, Options and Recommendations guidelines. Summary report. Eur J Dermatol 17:325–331

    PubMed  Google Scholar 

  • Schultz S, Kane M, Roush R, Miller V, Berd D, Goldman L, Mastrangelo M (1990) Time to recurrence varies inversely with thickness in clinical stage 1 cutaneous melanoma. Surg Gynecol Obstet 171:393–397

    CAS  PubMed  Google Scholar 

  • Snoswell CL, Caffery LJ, Whitty JA, Soyer HP, Gordon LG (2018) Cost-effectiveness of skin cancer referral and consultation using teledermoscopy in Australia. JAMA Dermatol 154:694–700

    Article  PubMed  PubMed Central  Google Scholar 

  • The National Cancer Institute, S., Epidemiology, and End Results Program (2018) Cancer stat facts: melanoma of the skin [Online]. https://seer.cancer.gov/statfacts/html/melan.html. Accessed 31 Aug 2018

  • Thomas JM, Newton-Bishop J, A’Hern R, Coombes G, Timmons M, Evans J, Cook M, Theaker J, Fallowfield M, O’Neill T, Ruka W, Bliss JM, United Kingdom Melanoma Study, G, British Association of Plastic, S, Scottish Cancer Therapy, N (2004) Excision margins in high-risk malignant melanoma. N Engl J Med 350:757–766

    Article  CAS  PubMed  Google Scholar 

  • Trask PC, Paterson AG, Griffith KA, Riba MB, Schwartz JL (2003) Cognitive-behavioral intervention for distress in patients with melanoma: comparison with standard medical care and impact on quality of life. Cancer 98:854–864

    Article  PubMed  Google Scholar 

  • Truong A, Strazzulla L, March J, Boucher KM, Nelson KC, Kim CC, Grossman D (2016) Reduction in nevus biopsies in patients monitored by total body photography. J Am Acad Dermatol 75:135–143 e5

    Article  PubMed  Google Scholar 

  • Turner RM, Bell KJ, Morton RL, Hayen A, Francken AB, Howard K, Armstrong B, Thompson JF, Irwig L (2011) Optimizing the frequency of follow-up visits for patients treated for localized primary cutaneous melanoma. J Clin Oncol 29:4641–4646

    Article  PubMed  Google Scholar 

  • Veronesi U, Farante G, Galimberti V, Greco M, Luini A, Sacchini V, Andreola S, Leoni F, Menard S, Ronco M et al (1991) Evaluation of resection margins after breast conservative surgery with monoclonal antibodies. Eur J Surg Oncol 17:338–341

    CAS  PubMed  Google Scholar 

  • Vuylsteke RJ, Van Leeuwen PA, Statius Muller MG, Gietema HA, Kragt DR, Meijer S (2003) Clinical outcome of stage I/II melanoma patients after selective sentinel lymph node dissection: long-term follow-up results. J Clin Oncol 21:1057–1065

    Article  CAS  PubMed  Google Scholar 

  • Watts CG, Dieng M, Morton RL, Mann GJ, Menzies SW, Cust AE (2015) Clinical practice guidelines for identification, screening and follow-up of individuals at high risk of primary cutaneous melanoma: a systematic review. Br J Dermatol 172:33–47

    Article  CAS  PubMed  Google Scholar 

  • Wheeler T (2006) Psychological consequences of malignant melanoma: patients’ experiences and preferences. Nurs Stand 21:42–46

    Article  CAS  PubMed  Google Scholar 

  • Youlden DR, Youl PH, Soyer HP, Aitken JF, Baade PD (2014) Distribution of subsequent primary invasive melanomas following a first primary invasive or in situ melanoma Queensland, Australia, 1982–2010. JAMA Dermatol 150:526–534

    Article  PubMed  Google Scholar 

  • Youlden DR, Baade PD, Soyer HP, Youl PH, Kimlin MG, Aitken JF, Green AC, Khosrotehrani K (2016) Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study. J Invest Dermatol 136:2270–2276

    Article  CAS  PubMed  Google Scholar 

  • Zhang H, Bermejo JL, Sundquist J, Hemminki K (2008) Modification of second cancer risk after malignant melanoma by parental history of cancer. Br J Cancer 99:536–538

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Morton, R.L., Francken, A.B., Dieng, M. (2019). Surveillance and Follow-Up of Melanoma Patients. In: Balch, C., et al. Cutaneous Melanoma. Springer, Cham. https://doi.org/10.1007/978-3-319-46029-1_28-1

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