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Cutaneous Photobiology

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  • First Online:
Atlas of Dermatology, Dermatopathology and Venereology

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Abstract

Photodermatology is a form of photobiology encompassing many interactions between light sources and the skin, from photo-induced or photo-exacerbated cutaneous diseases to light-based dermatologic therapies. This chapter aims to provide an overview of current photodermatologic topics. The first section reviews foundational principles upon which modern photodermatology is built, such as the electromagnetic spectrum, properties of light, and how it interacts with the skin. The majority of this chapter is dedicated to photodermatoses. Lastly, the chapter discusses several therapies such as phototherapy and lasers, which harness powerful light properties in clinical practice.

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References

  • Abeck D, Schmidt T, Fesq H, Strom K, Mempel M, Brockow K, Ring J (2000) Long-term efficacy of medium-dose UVA1 phototherapy in atopic dermatitis. J Am Acad Dermatol 42(2 Pt 1):254–257

    Article  CAS  PubMed  Google Scholar 

  • Ada S, Seçkin D, Budakoğlu I, Ozdemir FN (2005) Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study. J Am Acad Dermatol 53(1):149–151

    Article  PubMed  Google Scholar 

  • Alster TS (1995) Q-switched alexandrite laser treatment (755 nm) of professional and amateur tattoos. J Am Acad Dermatol 33(1):69–73

    Article  CAS  PubMed  Google Scholar 

  • Anderson B (2012) Rashes. In: The netter collection of medical illustrations: integumentary system, vol 4, 2nd edn. Saunders, Philadelphia, pp 71–148

    Google Scholar 

  • Anderson RR, Parrish JA (1981) The optics of human skin. J Invest Dermatol 77(1):13–19

    Article  CAS  PubMed  Google Scholar 

  • Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220(4596):524–527

    Article  CAS  PubMed  Google Scholar 

  • Anderson DS, Williams HS, Stockley AV (1954) The absorption of Grenz rays and low voltage x-rays by local applications. Br J Dermatol 66(4):144–146

    Article  CAS  PubMed  Google Scholar 

  • Anderson RR, Geronemus R, Kilmer SL, Farinelli W, Fitzpatrick RE (1993) Cosmetic tattoo ink darkening. A complication of Q-switched and pulsed-laser treatment. Arch Dermatol 129(8):1010–1014

    Article  CAS  PubMed  Google Scholar 

  • Ashkenazi H, Malik Z, Harth Y, Nitzan Y (2003) Eradication of Propionibacterium acnes by its endogenous porphyrins after illumination with high intensity blue light. FEMS Immunol Med Microbiol 35(1):17–24

    Article  CAS  PubMed  Google Scholar 

  • Ashourian N, Mousdicas N (2006) Images in clinical medicine. Pellagra-like dermatitis. N Engl J Med 354(15):1614

    Article  CAS  PubMed  Google Scholar 

  • Backman HA (1982) The effects of PUVA on the eye. Am J Optom Physiol Optic 59(1):86–89

    Article  CAS  Google Scholar 

  • Badri T, Ben Tekaya N, Cherif F, Ben Osman Dhahri A (2004) Photo-onycholysis: two cases induced by doxycycline. Acta Dermatovenerol Alp Pannonica Adriat 13(4):135–136

    CAS  PubMed  Google Scholar 

  • Bailey RL, West KP Jr, Black RE (2015) The epidemiology of global micronutrient deficiencies. Ann Nutr Metab 66(Suppl 2):22–33

    Article  CAS  PubMed  Google Scholar 

  • Bakkour W, Haylett AK, Gibbs NK, Chalmers RJ, Rhodes LE (2013) Photodistributed telangiectasia induced by calcium channel blockers: case report and review of the literature. Photodermatol Photoimmunol Photomed 29(5):272–275

    Article  PubMed  Google Scholar 

  • Baran R, Juhlin L (1987) Drug-induced photo-onycholysis. Three subtypes identified in a study of 15 cases. J Am Acad Dermatol 17(6):1012–1016

    Article  CAS  PubMed  Google Scholar 

  • Barthelemy H, Chouvet B, Cambazard F (1986) Skin and mucosal manifestations in vitamin deficiency. J Am Acad Dermatol 15(6):1263–1274

    Article  CAS  PubMed  Google Scholar 

  • Beer K, Applebaum D, Nousari C (2014) Pseudoporphyria: discussion of etiologic agents. Journal of drugs in dermatology. J Drugs Dermatol 13(8):990–992

    PubMed  Google Scholar 

  • Bens G (2014) Sunscreens. Adv Exp Med Biol 810:429–463

    PubMed  Google Scholar 

  • Bethea D, Fullmer B, Syed S, Seltzer G, Tiano J, Rischko C, Gillespie L, Brown D, Gasparro FP (1999) Psoralen photobiology and photochemotherapy: 50 years of science and medicine. J Dermatol Sci 19(2):78–88

    Article  CAS  PubMed  Google Scholar 

  • Bianchi B, Campolmi P, Mavilia L, Danesi A, Rossi R, Cappugi P (2003) Monochromatic excimer light (308 nm): an immunohistochemical study of cutaneous T cells and apoptosis-related molecules in psoriasis. J Eur Acad Dermatol Venereol 17(4):408–413

    Article  CAS  PubMed  Google Scholar 

  • Bickers DR, Frank J (2012) The porphyrias. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K (eds) Fitzpatrick’s dermatology in deneral medicine, 8th edn. McGraw-Hill, New York

    Google Scholar 

  • Bjerring P, Christiansen K, Troilius A, Dierickx C (2004) Facial photo rejuvenation using two different intense pulsed light (IPL) wavelength bands. Lasers Surg Med 34(2):120–126

    Article  PubMed  Google Scholar 

  • Bleasel NR, Stapleton KM, Lee MS, Sullivan J (1999) Vitamin a deficiency phrynoderma: due to malabsorption and inadequate diet. J Am Acad Dermatol 41(2 Pt 2):322–324

    Article  CAS  PubMed  Google Scholar 

  • Bolognia J, Jorizzo J, Schaffer J (2012) Dermatology, 3rd edn. Elsevier Limited, Philadelphia

    Google Scholar 

  • Borgia F, Vaccaro M, Guarneri F, Cannavo SP (2000) Photodistributed telangiectasia following use of cefotaxime. British J Dermatol 143(3):674–675

    Article  CAS  Google Scholar 

  • Botto NC, Warshaw EM (2008) Solar urticaria. J Am Acad Dermatol 59(6):909–920. quiz 921-902

    Article  PubMed  Google Scholar 

  • Breuckmann F, Gambichler T, Altmeyer P, Kreuter A (2004) UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review. BMC Dermatol 4(1):11

    Article  PubMed  PubMed Central  Google Scholar 

  • Bruynzeel DP, Ferguson J, Andersen K, Goncalo M, English J, Goossens A, Holzle E, Ibbotson SH, Lecha M, Lehmann P, Leonard F, Moseley H, Pigatto P, Tanew A, European Taskforce for Photopatch T (2004) Photopatch testing: a consensus methodology for Europe. J Eur Acad Dermatol Venereol 18(6):679–682

    Article  CAS  PubMed  Google Scholar 

  • Burgin S, Goldsmith LA, Craft N (2017) Erythropoietic porphyria. In: Goldsmith LA (ed) VisualDx. Rochester, New York

    Google Scholar 

  • Chambial S, Dwivedi S, Shukla KK, John PJ, Sharma P (2013) Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem 28(4):314–328

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Charlesworth P, Truscott TG (1993) The use of 5-aminolevulinic acid (ALA) in photodynamic therapy (PDT). J Photochem Photobiol B 18(1):99–100

    Article  CAS  PubMed  Google Scholar 

  • Cipollaro VA (1991) Grenz rays. Int J Dermatol 30(3):225–226

    Article  CAS  PubMed  Google Scholar 

  • Cislo M, Maj J (1988) Results of treatment by the PUVA method in patients with atopic dermatitis. Pol Tyg Lek 43(3–4):103–106

    CAS  PubMed  Google Scholar 

  • Cohen LE, Grant RT (2016) Sun protection: current management strategies addressing UV exposure. Clin Plast Surg 43(3):605–610

    Article  PubMed  Google Scholar 

  • Cohen DK, Lee PK (2016) Photodynamic therapy for non-melanoma skin cancers. Cancers (Basel) 8(10):90

    Article  CAS  Google Scholar 

  • Crandon JH, Lund CC, Dill DB (1940) Experimental human scurvy. N Engl J Med 223(10):353–369

    Article  CAS  Google Scholar 

  • Darby-Stewart A, Edwards F, Perry K (2006) Hyperpigmentation and vesicles after beach vacation. J Fam Pract 55(12):1050–1053

    PubMed  Google Scholar 

  • Das J, Reynolds RV (2014) Recent advances in acne pathogenesis: implications for therapy. Am J Clin Dermatol 15(6):479–488

    Article  PubMed  Google Scholar 

  • de Guidi G, Bracchitta G, Catalfo A (2011) Photosensitization reactions of fluoroquinolones and their biologic consequences. Photochem Photobiol 87(6):1214–1229

    Article  PubMed  CAS  Google Scholar 

  • Diffey BL, Farr PM, Oakley AM (1987) Quantitative studies on UVA-induced erythema in human skin. Br J Dermatol 117(1):57–66

    Article  CAS  PubMed  Google Scholar 

  • Dogra S, Kanwar AJ (2004) Narrow band UVB phototherapy in dermatology. Indian J Dermatol Venereol Leprol 70(4):205–209

    PubMed  Google Scholar 

  • Dong D, Jiang M, Xu X, Guan M, Wu J, Chen Q, Xiang L (2012) The effects of NB-UVB on the hair follicle-derived neural crest stem cells differentiating into melanocyte lineage in vitro. J Dermatol Sci 66(1):20–28

    Article  CAS  PubMed  Google Scholar 

  • Drucker AM, Rosen CF (2011) Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf 34(10):821–837

    Article  CAS  PubMed  Google Scholar 

  • Eichenfield DZ, Cohen PR (2016) Amitriptyline-induced cutaneous hyperpigmentation: case report and review of psychotropic drug-associated mucocutaneous hyperpigmentation. Dermatol Online J 22(2). Pii: 13030/qt3455571b

    Google Scholar 

  • Elder GH (2003) Porphyria cutanea tarda and related disorders. In: Kadish K, Smith K, Guilard R (eds) The oorphyrin handbook, vol 14. Elsevier Science, San Diego, pp 67–92

    Chapter  Google Scholar 

  • Elder D, Elenitsas R, Johnson B, Murphy G, Xu X (2009) Lever’s histopathology of the skin, 10th edn. Lippincott Williams & Wilkins, Philadelphia, p 691

    Google Scholar 

  • El-Mofty M, Mostafa W, El-Darouty M, Bosseila M, Nada H, Yousef R, Esmat S, El-Lawindy M, Assaf M, El-Enani G (2004) 20(3):148–156

    Google Scholar 

  • Ericson MB, Wennberg AM, Larko O (2008) Review of photodynamic therapy in actinic keratosis and basal cell carcinoma. Ther Clin Risk Manag 4(1):1–9

    CAS  PubMed  PubMed Central  Google Scholar 

  • Esmat S, Mostafa W, Hegazy RA, Shalaby S, Sheth V, Youssef R, El-Mofty M (2016) Phototherapy: the vitiligo management pillar. Clin Dermatol 34(5):594–602

    Article  PubMed  Google Scholar 

  • Fai D, Romano I, Fai C, Cassano N, Vena GA (2016) Daylight photodynamic therapy with methyl aminolaevulinate in patients with actinic keratoses: a preliminary experience in southern Italy. G Ital Dermatol Venereol 151(2):154–159

    PubMed  Google Scholar 

  • Feldman SR, Mellen BG, Housman TS, Fitzpatrick RE, Geronemus RG, Friedman PM, Vasily DB, Morison WL (2002) Efficacy of the 308-nm excimer laser for treatment of psoriasis: results of a multicenter study. J Am Acad Dermatol 46(6):900–906

    Article  PubMed  Google Scholar 

  • Fossitt DD, Kowalski TJ (2014) Classic skin findings of scurvy. Mayo Clin Proc 89(7):e61

    Article  PubMed  Google Scholar 

  • Freeman SE, Hacham H, Gange RW, Maytum DJ, Sutherland JC, Sutherland BM (1989) Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. Proc Natl Acad Sci U S A 86(14):5605–5609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fritsch C, Bolsen K, Ruzicka T, Goerz G (1997) Congenital erythropoietic porphyria. J Am Acad Dermatol 36(4):594–610

    Article  CAS  PubMed  Google Scholar 

  • Galimberti F, Mesinkovska NA (2016) Skin findings associated with nutritional deficiencies. Cleve Clin J Med 83(10):731–739

    Article  PubMed  Google Scholar 

  • Gange RW, Anderson RR, Gonzalez E (1988) Laser treatment of port-wine stains. Br J Dermatol 119(1):131–132

    Article  CAS  PubMed  Google Scholar 

  • Gardeazabal J, Gonzalez-Perez R, Bilbao I, Alvarez-Hernandez MI, Aguirre A, Diaz-Perez JL (1998) Solar urticaria enhanced through clothing. Photodermatol Photoimmunol Photomed 14(5–6):164–166

    Article  CAS  PubMed  Google Scholar 

  • Gasparro FP, Mitchnick M, Nash JF (1998) A review of sunscreen safety and efficacy. Photochem Photobiol 68(3):243–256

    Article  CAS  PubMed  Google Scholar 

  • Gawkrodger D, Ardern-Jones M (2017) Photodermatology. In: Dermatology: an illustrated colour text, 6th edn. Elsevier, Philadelphia, pp 48–49

    Google Scholar 

  • Ghavanini AA, Kimpinski K (2014) Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. J Clin Neuromuscul Dis 16(1):25–31

    Article  PubMed  Google Scholar 

  • Gilchrest BA, Soter NA, Stoff JS, Mihm MC Jr (1981) The human sunburn reaction: histologic and biochemical studies. J Am Acad Dermatol 5(4):411–422

    Article  CAS  PubMed  Google Scholar 

  • Glatz M, Hofbauer GF (2012) Phototoxic and photoallergic cutaneous drug reactions. Chem Immunol Allergy 97:167–179

    Article  CAS  PubMed  Google Scholar 

  • Goetze S, Elsner P (2015) Solar urticaria. J Dtsch Dermatol Ges 13(12):1250–1253

    PubMed  Google Scholar 

  • Goncalo M, Ferguson J, Bonevalle A, Bruynzeel DP, Gimenez-Arnau A, Goossens A, Kerr A, Lecha M, Neumann N, Niklasson B, Pigatto P, Rhodes LE, Rustemeyer T, Sarkany R, Thomas P, Wilkinson M (2013) Photopatch testing: recommendations for a European photopatch test baseline series. Contact Dermatitis 68(4):239–243

    Article  PubMed  Google Scholar 

  • Gould JW, Mercurio MG, Elmets CA (1995) Cutaneous photosensitivity diseases induced by exogenous agents. J Am Acad Dermatol 33(4):551–573. quiz 574-556

    Article  CAS  PubMed  Google Scholar 

  • Gregoriou S, Karagiorga T, Stratigos A, Volonakis K, Kontochristopoulos G, Rigopoulos D (2008) Photo-onycholysis caused by olanzapine and aripiprazole. J Clin Psychopharmacol 28(2):219–220

    Article  PubMed  Google Scholar 

  • Grinblat BM, Festa Neto C, Sanches JA Jr, Szeimies RM, Oliveira AP, Torezan LA (2015) Daylight photodynamic therapy for actinic keratosis in Sao Paulo, Brazil Photodermatol. Photoimmunol Photomed 31(1):54–56

    Article  Google Scholar 

  • Grossman ME, Bickers DR, Poh-Fitzpatrick MB, Deleo VA, Harber LC (1979) Porphyria cutanea tarda. Clinical features and laboratory findings in 40 patients. Am J Med 67(2):277–286

    Article  CAS  PubMed  Google Scholar 

  • Habif TP (2016) Psoriasis and other papulosquamous diseases. In: Habif TP (ed) Clinical dermatology, 6th edn. Elsevier, Philadelphia, pp 263–328

    Google Scholar 

  • Handler NS, Handler MZ, Stephany MP, Handler GA, Schwartz RA (2017) Porphyria cutanea tarda: an intriguing genetic disease and marker. Int J Dermatol 56(6):e106–e117

    Article  PubMed  Google Scholar 

  • Hayashi S, Ikeda M, Kitamura Y, Hamasaki Y, Hatamochi A (2012) UVA irradiation following treatment with topical 8-methoxypsoralen improves bleomycin-induced scleroderma in a mouse model, by reducing the collagen content and collagen gene expression levels in the skin. J Dermatol Sci 67(1):20–25

    Article  CAS  PubMed  Google Scholar 

  • Heath ML, Sidbury R (2006) Cutaneous manifestations of nutritional deficiency. Curr Opin Pediatr 18(4):417–422

    Article  PubMed  Google Scholar 

  • Henderson BW, Dougherty TJ (1992) How does photodynamic therapy work? Photochem. Photo-Dermatology 55(1):145–157

    CAS  Google Scholar 

  • Herd RM, Dover JS, Arndt KA (1997) Basic laser principles. Dermatol Clin 15(3):355–372

    Article  CAS  PubMed  Google Scholar 

  • Herrling T, Jung K, Fuchs J (2006) Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin. Spectrochim Acta A Mol Biomol Spectrosc 63(4):840–845

    Article  PubMed  CAS  Google Scholar 

  • Heshmati F (2003) Mechanisms of action of extracorporeal photochemotherapy. Transfus Apher Sci 29(1):61–70

    Article  CAS  PubMed  Google Scholar 

  • Hift RJ, Peters TJ, Meissner PN (2012) A review of the clinical presentation, natural history and inheritance of variegate porphyria: its implausibility as the source of the ‘Royal Malady’. J Clin Pathol 65(3):200–205

    Article  PubMed  Google Scholar 

  • Hirschmann JV, Raugi GJ (1999) Adult scurvy. J Am Acad Dermatol 41(6):895–906. quiz 907-910

    Article  CAS  PubMed  Google Scholar 

  • Hobbs L, Ort R, Dover J (2000) Synopsis of laser assisted hair removal systems. Skin Therapy Lett 5(3):1–5

    CAS  PubMed  Google Scholar 

  • Hodak E, Pavlovsky L (2015) Phototherapy of mycosis fungoides. Dermatol Clin 33(4):697–702

    Article  PubMed  CAS  Google Scholar 

  • Holland V, Bernhard JD, Craft N, Fox LP, Goldsmith LA, Tharp MD (2017) Variegate porphyria. In: Goldsmith LA (ed) VisualDx. Rochester, New York

    Google Scholar 

  • Holme SA, Anstey AV, Finlay AY, Elder GH, Badminton MN (2006) Erythropoietic protoporphyria in the U.K.: clinical features and effect on quality of life. Br J Dermatol 155(3):574–581

    Article  CAS  PubMed  Google Scholar 

  • Honigsmann H (2008) Polymorphous light eruption. Photodermatol Photoimmunol Photomed 24(3):155–161

    Article  PubMed  Google Scholar 

  • Honigsmann H, Schwarz T (2012) Ultraviolet therapy. In: Bolognia JL, Jorizzo JL, Schaffer JV (eds) Dermatology, 3rd edn. Elsevier, London, pp 2219–2224

    Google Scholar 

  • Honigsmann H, Schuler G, Aberer W, Romani N, Wolff K (1986) Immediate pigment darkening phenomenon. A reevaluation of its mechanisms. J Invest Dermatol 87(5):648–652

    Article  CAS  PubMed  Google Scholar 

  • Horio T (2003) Solar urticaria-idiopathic? Photodermatol Photoimmunol Photomed 19(3):147–154

    Article  PubMed  Google Scholar 

  • Horner ME, Alikhan A, Tintle S, Tortorelli S, Davis DMR, Hand JL (2013) Cutaneous porphyrias part I: epidemiology, pathogenesis, presentation, diagnosis, and histopathology. Int J Dermatol 52(12):1464–1480

    Article  PubMed  Google Scholar 

  • James W, Berger T, Elston D (2011) Andrews’ diseases of the skin: clinical dermatology, 11th edn. Elsevier, Philadelphia, pp 28–29

    Google Scholar 

  • Jarrett P, Scragg R (2017) A short history of phototherapy, vitamin D and skin disease. Photochem Photobiol Sci 16(30):283–290

    Article  CAS  PubMed  Google Scholar 

  • Jaworski K, Walecka I, Rudnicka L, Gnatowski M, Kosior DA (2014) Cutaneous adverse reactions of amiodarone. Med Sci Monit 20:2369–2372

    Article  PubMed  PubMed Central  Google Scholar 

  • Jung YR, Kim SJ, Sohn KC, Lee Y, Seo YJ, Lee YH, Whang KU, Kim CD, Lee JH, Im M (2015) Regulation of lipid production by light-emitting diodes in human sebocytes. Arch Dermatol Res 307(3):265–273

    Article  CAS  PubMed  Google Scholar 

  • Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S (2007) Improvement of naturally aged skin with vitamin a (retinol). Arch Dermatol 143(5):606–612

    Article  CAS  PubMed  Google Scholar 

  • Karthikeyan K, Thappa DM (2002) Pellagra and skin. Int J Dermatol 41(8):476–481

    Article  PubMed  Google Scholar 

  • Kawada A (1986) UVB-induced erythema, delayed tanning, and UVA-induced immediate tanning in Japanese skin. Photo-Dermatology 3(6):327–333

    CAS  PubMed  Google Scholar 

  • Kay RG, Tasman-Jones C (1975) Letter: zinc deficiency and intravenous feeding. Lancet 2(7935):605–606

    Article  CAS  PubMed  Google Scholar 

  • Kerr A, Ferguson J (2010) Photoallergic contact dermatitis. Photodermatol Photoimmunol Photomed 26(2):56–65

    Article  CAS  PubMed  Google Scholar 

  • Krueger JG, Wolfe JT, Nabeya RT, Vallat VP, Gilleaudeau P, Heftler NS, Austin LM, Gottlieb AB (1995) Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells. J Exp Med 182(6):2057–2068

    Article  CAS  PubMed  Google Scholar 

  • Krutmann J (2001) The role of UVA rays in skin aging. Eur J Dermatol 11(2):170–171

    CAS  PubMed  Google Scholar 

  • Kutlubay Z, Sevim A, Engin B, Tuzun Y (2014) Photodermatoses, including phototoxic and photoallergic reactions (internal and external). Clin Dermatol 32(1):73–79

    Article  PubMed  Google Scholar 

  • Lassen HC (1930) Vitamin a deficiency and resistance against a specific infection. Preliminary report. J Hyg (Lond) 30(3):300–310

    Article  CAS  Google Scholar 

  • Lasser AE, Steiner MM (1978) Tetracycline photo-onycholysis. Pediatrics 61(1):98–99

    CAS  PubMed  Google Scholar 

  • Le Duff F, Fontas E, Giacchero D, Sillard L, Lacour JP, Ortonne JP, Passeron T (2010) 308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized study. Br J Dermatol 163(1):188–192

    PubMed  Google Scholar 

  • Lee WJ, Lee KC, Kim MJ, Jang YH, Lee SJ, Kim DW (2016) Efficacy of red or infrared light-emitting diodes in a mouse model of Propionibacterium acnes-induced inflammation. Ann Dermatol 28(2):186–191

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lehmann P, Schwarz T (2011) Photodermatoses: diagnosis and treatment. Dtsch Arztebl Int 108(9):135–141

    PubMed  PubMed Central  Google Scholar 

  • Lepselter J, Elman M (2004) Biological and clinical aspects in laser hair removal. J Dermatol Treat 15(2):72–83

    Article  CAS  Google Scholar 

  • Levine VJ, Geronemus RG (1995) Tattoo removal with the Q-switched ruby laser and the Q-switched Nd:YAGlaser: a comparative study. Cutis 55(5):291–296

    CAS  PubMed  Google Scholar 

  • Lim HW, Silpa-archa N, Amadi U, Menter A, Van Voorhees AS, Lebwohl M (2015) Phototherapy in dermatology: a call for action. J Am Acad Dermatol 72(6):1078–1080

    Article  PubMed  Google Scholar 

  • Lindelof B, Liden S, Ros AM (1984) Effect of grenz rays on Langerhans’ cells in human epidermis. Acta Derm Venereol 64(5):436–438

    CAS  PubMed  Google Scholar 

  • Lindelöf B, Sigurgeirsson B, Tegner E, Larkö O, Johannesson A, Berne B, Christensen OB, Andersson T, Törngren M, Molin L (1991) PUVA and cancer: a large-scale epidemiological study. Lancet 338(8759):91–93

    Article  PubMed  Google Scholar 

  • Loewenthal L (1933) A new cutaneous manifestation in the syndrome of vitamin a deficiency. Arch Dermatol Syphilol 28(5):700–708

    Article  Google Scholar 

  • Lugovic Mihic L, Bulat V, Situm M, Cavka V, Krolo I (2008) Allergic hypersensitivity skin reactions following sun exposure. Coll Antropol 32(Suppl 2):153–157

    PubMed  Google Scholar 

  • Maerker JM, Harm A, Foeldvari I, Hoger PH (2001) Naproxen-induced pseudoporphyria. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 52(11):1026–1029

    Article  CAS  PubMed  Google Scholar 

  • Maier T, Korting HC (2005) Sunscreens – which and what for? Skin Pharmacol Physiol 18(6):253–262

    Article  CAS  PubMed  Google Scholar 

  • Mancuso JB, Maruthi R, Wang SQ, Lim HW (2017) Sunscreens: An update. Am J Clin Dermatol 18(5):643–650

    Article  PubMed  Google Scholar 

  • Marcos L, Kahler R (2015) Phytophotodermatitis. Int J Infect Dis 38:7–8

    Article  PubMed  Google Scholar 

  • Maso M, Ruszkowski A, Bauerle J (1991) Celery Phytophotodermatitis in a chef. Arch Dermatol 127(6):912–913

    Article  CAS  PubMed  Google Scholar 

  • Mehraban S, Feily A (2014) 308nm excimer laser in dermatology. J Lasers Med Sci 5(1):8–12

    PubMed  PubMed Central  Google Scholar 

  • Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB, Gottlieb A, Koo JY, Lebwohl M, Lim HW, Van Voorhees AS, Beutner KR, Bhushan R (2010) Guidelines of care for the management of psoriasis and psoriatic arthritis: section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 62(1):114–135

    Article  PubMed  Google Scholar 

  • Moloney FJ, Collins S, Murphy GM (2002) Sunscreens: safety, efficacy and appropriate use. Am J Clin Dermatol 3(3):185–191

    Article  PubMed  Google Scholar 

  • Monteiro AF, Rato M, Martins C (2016) Drug-induced photosensitivity: Photoallergic and phototoxic reactions. Clin Dermatol 34(5):571–581

    Article  PubMed  Google Scholar 

  • Morison WL, Parrish J, Fitzpatrick TB (1978) Oral psoralen photochemotherapy of atopic eczema. Br J Dermatol 98(1):25–30

    Article  CAS  PubMed  Google Scholar 

  • Morison WL, Baughman RD, Day RM, Forbes PD, Hoenigsmann H, Krueger GG, Lebwohl M, Lew R, Naldi L, Parrish JA, Piepkorn M, Stern RS, Weinstein GD, Whitmore SE (1993) Consensus workshop on the toxic effects of long-term PUVA therapy. Arch Dermatol 134(5):595–598

    Google Scholar 

  • Mouzakis JA, Liu S, Cohen G (2011) Rapid response of facial vitiligo to 308 nm excimer laser and topical calcipotriene. J Clin Aesthet Dermatol 4(6):41–44

    PubMed  PubMed Central  Google Scholar 

  • Moynahan EJ (1974) Letter: Acrodermatitis enteropathica: a lethal inherited human zinc-deficiency disorder. Lancet 2(7877):399–400

    Article  CAS  PubMed  Google Scholar 

  • Nistor N, Ciontu L, Frasinariu OE, Lupu VV, Ignat A, Streanga V (2016) Acrodermatitis enteropathica: a case report. Medicine (Baltimore) 95(20):e3553

    Article  Google Scholar 

  • Novák Z, Bónis B, Baltás E, Ocsovszki I, Ignácz F, Dobozy A, Kemény L (2002) Xenon chloride ultraviolet B laser is more effective in treating psoriasis and in inducing T cell apoptosis than narrow-band ultraviolet B. J Photochem Photobiol B 67(1):32–38

    Article  PubMed  Google Scholar 

  • Oldham MA, Ivkovic A (2012) Pellagrous encephalopathy presenting as alcohol withdrawal delirium: a case series and literature review. Addict Sci Clin Pract 7:12

    Article  PubMed  PubMed Central  Google Scholar 

  • Omi T, Numano K (2014) The role of the CO2 laser and fractional CO2 laser in dermatology. Laser Ther 23(1):49–60

    Article  PubMed  PubMed Central  Google Scholar 

  • Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y (2017) Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments. J Dermatol Sci 85(1):4–11

    Article  CAS  PubMed  Google Scholar 

  • Paller A, Mancini A (2016) Hurwitz clinical pediatric dermatology, 5th edn. Elsevier, Philadelphia, pp 448–466

    Google Scholar 

  • Patrizi A, Raone B, Ravaioli GM (2015) Management of Atopic Dermatitis: safety and efficacy of phototherapy. Clin Cosmet Investig Dermatol 8:511–520

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patterson J (2013) Pigmentation disorders. In: Practical skin pathology: a diagnostic approach. Saunders, Philadelphia, pp 221–229

    Google Scholar 

  • Patterson J (2016) Weedon’s skin pathology, 4th edn. Elsevier Limited, Philadelphia

    Google Scholar 

  • Perafán-Riveros C, França LF, Alves AC, Sanches JA Jr (2002) Acrodermatitis enteropathica: case report and review of the literature. Pediatr Dermatol 19(5):426–431

    Article  PubMed  Google Scholar 

  • Pinnell SR (2003) Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol 48(1):1–19; quiz 20-2

    Article  PubMed  Google Scholar 

  • Powers HJ (2003) Riboflavin (vitamin B-2) and health. Am J Clin Nutr 77(6):1352–1360

    Article  CAS  PubMed  Google Scholar 

  • Prasad AS, Oberleas D (1973) Zinc deficiency in man. Lancet 1(7818):1520–1521

    Article  CAS  PubMed  Google Scholar 

  • Raam R, DeClerck B, Jhun P, Herbert M (2016) Phytophotodermatitis: the other “lime” disease. Ann Emerg Med 67:554–556

    Article  PubMed  Google Scholar 

  • Ragunatha S, Kumar VJ, Murugesh SB (2011) A clinical study of 125 patients with phrynoderma. Indian J Dermatol 56(4):389–392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramanujam V-MS, Anderson KE (2015) Porphyria diagnostics—part 1: a brief overview of the porphyrias. Curr Protoc Hum Genet 86:17.20.1–17.20.26

    Google Scholar 

  • Reuler JB, Broudy VC, Cooney TG (1985) Adult scurvy. JAMA 253(6):805–807

    Article  CAS  PubMed  Google Scholar 

  • Reyes BA, Geronemus R (1990) Treatment of port-wine stains during childhood with the flashlamp-pumped pulsed dye laser. J Am Acad Dermatol 23(6 Pt 1):1142–1148

    Article  CAS  PubMed  Google Scholar 

  • Rivard J, Lim HW (2005) Ultraviolet phototherapy for pruritus. Dermatol Ther 18(4):344–354

    Article  PubMed  Google Scholar 

  • Rodenbeck DL, Silverberg JI, Silverberg NB (2016) Phototherapy for atopic dermatitis. Clin Dermatol 34(5):607–613

    Article  PubMed  Google Scholar 

  • Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, Harris JE, Vitiligo Working Group (2017) Current and emerging treatments for vitiligo. J Am Acad Dermatol 77(1):17–29

    Article  PubMed  Google Scholar 

  • Roe DA (1991) Riboflavin deficiency: mucocutaneous signs of acute and chronic deficiency. Semin Dermatol 10(4):293–295

    CAS  PubMed  Google Scholar 

  • Ross EV, Yashar S, Michaud N, Fitzpatrick R, Geronemus R, Tope WD, Anderson RR (2001) Tattoo darkening and nonresponse after laser treatment: a possible role for titanium dioxide. Arch Dermatol 137(1):33–37

    Article  CAS  PubMed  Google Scholar 

  • Sambandan DR, Ratner D (2011) Sunscreens: an overview and update. J Am Acad Dermatol 64(4):748–758

    Article  CAS  PubMed  Google Scholar 

  • Schiltz JR, Lanigan J, Nabial W, Petty B, Birnbaum JE (1986) Retinoic acid induces cyclic changes in epidermal thickness and dermal collagen and glycosaminoglycan biosynthesis rates. J Invest Dermatol 87(5):663–667

    Article  CAS  PubMed  Google Scholar 

  • Semba RD (1994) Vitamin a, immunity, and infection. Clin Infect Dis 19(3):489–499

    Article  CAS  PubMed  Google Scholar 

  • Shankar AH, Prasad AS (1998) Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 68(2 Suppl):447S–463S

    Article  CAS  PubMed  Google Scholar 

  • Sharp MT, Horn TD (2005) Pseudoporphyria induced by voriconazole. J Am Acad Dermatol 53(2):341–345

    Article  PubMed  Google Scholar 

  • Shenoi SD, Prabhu S (2014) Photochemotherapy (PUVA) in psoriasis and vitiligo. Indian J Dermatol Venereol Leprol 80(6):497–504

    Article  PubMed  Google Scholar 

  • Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, Chamlin SL, Cooper KD, Feldman SR, Hanifin JM, Krol A, Margolis DJ, Paller AS, Schwarzenberger K, Silverman RA, Simpson EL, Tom WL, Williams HC, Elmets CA, Block J, Harrod CG, Begolka WS, Eichenfield LF, American Academy of Dermatology (2014) Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol 71(2):327–349

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith A, Di Primio G, Humphrey-Murto S (2011) Scurvy in the developed world. CMAJ 183(11):E752–E755

    Article  PubMed  PubMed Central  Google Scholar 

  • Stern RS, Lunder EJ (1998) Risk of squamous cell carcinoma and methoxsalen (psoralen) and UV-A radiation (PUVA). A meta-analysis. Arch Dermatol 134:1582–1585

    CAS  PubMed  Google Scholar 

  • Tanew A, Ortel B, Wolff K, Honigsmann H (1986) PUVA for cutaneous T-cell lymphoma. 10 years after. Curr Probl Dermatol 15:232–237

    Article  CAS  PubMed  Google Scholar 

  • Tintle S, Shemer A, Suárez-Fariñas M, Fujita H, Gilleaudeau P, Sullivan-Whalen M, Johnson-Huang L, Chiricozzi A, Cardinale I, Duan S, Bowcock A, Krueger JG, Guttman-Yassky E (2011) Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response. J Allergy Clin Immunol 128(3): 583–593.e1-4

    Article  CAS  Google Scholar 

  • Valejo Coelho MM, Apetato M (2016) The dark side of the light: phototherapy adverse effects. Clin Dermatol 34(5):556–562

    Article  PubMed  Google Scholar 

  • Walsh JT Jr, Flotte TJ, Anderson RR, Deutsch TF (1988) Pulsed CO2 laser tissue ablation: effect of tissue type and pulse duration on thermal damage. Lasers Surg Med 8(2):108–118

    Article  PubMed  Google Scholar 

  • Walters IB, Burack LH, Coven TR, Gilleaudeau P, Krueger JG (1999) Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris. J Am Acad Dermatol 40(6 Pt 1):893–900

    Article  CAS  PubMed  Google Scholar 

  • Wechsler HL (1979) Vitamin a deficiency following small-bowel bypass surgery for obesity. Arch Dermatol 115(1):73–75

    Article  CAS  PubMed  Google Scholar 

  • Weichenthal M, Schwarz T (2005) Phototherapy: how does UV work? Photodermatol Photoimmunol Photomed 21(5):260–266

    Article  CAS  PubMed  Google Scholar 

  • Wiesmann A, Weller A, Lischka G, Klingebiel T, Kanz L, Einsele H (1999) Treatment of acute graft-versus-host disease with PUVA (psoralen and ultraviolet irradiation); results from a pilot study. Bone Marrow Transplant 23(2):151–155

    Article  CAS  PubMed  Google Scholar 

  • Willis I, Cylus L (1977) UVA erythema in skin: is it a sunburn? J Invest Dermatol 68(3):128–129

    Article  CAS  PubMed  Google Scholar 

  • Wilm A, Berneburg M (2015) Photoallergy. J Dtsch Dermatol Ges 13(1):7–12. quiz 13

    PubMed  Google Scholar 

  • Wolf G (1978) A historical note on the mode of administration of vitamin a for the cure of night blindness. Am J Clin Nutr 31(2):290–292

    Article  CAS  PubMed  Google Scholar 

  • Wolff K, Johnson R, Saavedra A (2013) Photosensitivity, photo-induced disorders, and disorders by ionizing radiation. In: Fitzpatrick’s color atlas and synopsis of clinical dermatology, 7th edn. The MGraw-Hill Companies Inc, New York

    Google Scholar 

  • Yadav RK (2009) Definitions in laser technology. J Cutan Aesthet Surg 2(1):45–46

    Article  PubMed  PubMed Central  Google Scholar 

  • Yones SS, Palmer RA, Garibaldinos TM, Hawk JL (2007) Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs narrowband-UV-B therapy. Arch Dermatol 143(5):578–584

    Article  CAS  PubMed  Google Scholar 

  • Zanolli M (2003) Phototherapy treatment of psoriasis today. J Am Acad Dermatol 49(2 Suppl):S78–S86

    Article  PubMed  Google Scholar 

  • Zitelli B, McIntire S, Nowalk A (2012) Child abuse and neglect: differential diagnosis of surface bruises. In: Atlas of pediatric physical diagnosis, 6th edn. Elsevier, Philadelphia

    Google Scholar 

  • Zuba EB, Koronowska S, Osmola-Mankowska A, Jenerowicz D (2016) Drug-induced photosensitivity. Acta Dermatovenerol Croat 24(1):55–64

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Weill Cornell Medical College, New York, NY, USA

    Jonathan Hale Zippin, Steven He, Jonathan Galati, Emily Rachel Lebowitz, Stephanie Sutter, Bernice Y. Yan & Dalee Zhou

  2. Albert Einstein College of Medicine, New York, NY, USA

    Jenny Z. Wang & Olivia H. Wind

  3. SUNY Downstate College of Medicine, Brooklyn, NY, USA

    Koji Ota

  4. New York Institute of Technology College of Osteopathic Medicine (NYITCOM), Old Westbury, NY, USA

    Anita Gade

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  1. Jonathan Hale Zippin
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    Bruce Smoller

  2. Khorramshahr, Iran

    Nooshin Bagherani

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Zippin, J.H. et al. (2020). Cutaneous Photobiology. In: Smoller, B., Bagherani, N. (eds) Atlas of Dermatology, Dermatopathology and Venereology . Springer, Cham. https://doi.org/10.1007/978-3-319-45134-3_65-1

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