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Pathology of the Gastrointestinal Tract pp 600–602Cite as

Pseudogoblet Cells

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Part of the book series: Encyclopedia of Pathology ((EP))

Overview

Pseudogoblet cells are distended columnar epithelial cells that mimic goblet cells. They are commonly detected in columnar-lined esophagus. These cells are important to recognize, since they are indicators of intestinal metaplasia in the esophagus and a diagnostic criterion of the Barrett esophagus according to the American College of Gastroenterology. The recognition of goblet cells guides the surveillance protocol, although the clinical validity has been debated, and thus it is vital to appreciate the histology and histochemical staining properties of pseudogoblet cells in order to differentiate them from goblet cells.

Histology of Goblet Cells Versus Pseudogoblet Cells

Goblet cells are mucin-producing cells normally present in the intestine (small and large), respiratory tract, and conjunctiva. They result from the accumulation of tightly packed large mucin granules at the cellular apex and consequently have a distinctive flask or wine goblet shape. The basal portion of the...

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References and Further Reading

  • Bronner, M. P. (2004). Inflammatory disorders of the GI tract: Inflammatory disorders of the esophagus. In R. D. Odze, J. R. Goldblum, & J. M. Crawford (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas (1st ed., pp. 121–1423). Philadelphia: Saunders.

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  • Ovalle, W. K., & Nahirney, P. C. (2013). Lower digestive system. In W. K. Ovalle & P. C. Nahirney (Eds.), Netter’s essential histology (2nd ed., pp. 285–309). Philadelphia: Saunders.

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  • Weinstein, W. M., & Ippoliti, A. F. (1996). The diagnosis of Barrett’s esophagus: Goblets, goblets, goblets. Gastrointestinal Endoscopy, 44(1), 91–95.

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  • Younes, M., Ertan, A., Ergun, G., Verm, R., Bridges, M., Woods, K., Meriano, F., Schmulen, A. C., Colman, R., Johnson, C., Barroso, A., Schwartz, J., McKechnie, J., Lechago, J., et al. (2007). Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Archives of Pathology & Laboratory Medicine, 131(4), 571–575.

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Author information

Authors and Affiliations

  1. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA

    Namrata Setia

  2. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Warren 219, Boston, MA, 02114, USA

    Gregory Y. Lauwers

Authors
  1. Namrata Setia
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  2. Gregory Y. Lauwers
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Corresponding author

Correspondence to Namrata Setia .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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© 2017 Springer-Verlag Berlin Heidelberg

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Setia, N., Lauwers, G.Y. (2017). Pseudogoblet Cells. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1674

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1674

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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