Synonyms
Atypical regenerative hyperplasia; Reactive hyperplasia
Definition
Pseudoepitheliomatous hyperplasia (PEH) is a morphologic pattern of reactive squamous epithelial proliferation that occurs in response to underlying infections, inflammations, or neoplasms (Kune 2012; Noffsinger 2007). It is characterized by parallel, elongated, and occasionally irregular columns of highly reactive squamous cells, with prominent nucleoli and abundant mitoses that may extend deep into the lamina propria. Its appearance may simulate invasive squamous cell carcinoma. On occasion, this reaction may be endoscopically visible, and this may cause diagnostic confusion with a malignant lesion (Odze 2009).
Clinical Features
As PEH is a reactive epithelial proliferation, and so its clinical features (incidence, age, sex, site, or macroscopic features) are mostly dependent on the underlying infectious, inflammatory, or neoplastic conditions.
Treatment
No specific treatment for this condition is required,...
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References and Further Reading
Bouquot, J. E. (2001). Diagnostic surgical pathology of the head and neck (pp. 205–207). Philadelphia: WB Saunders.
Kune, Y. T. (2012). The Korean Journal of Pathology, 46(4), 331–340.
Lamps, L. (2010). Diagnostic pathology: Gastrointestinal. Salt Lake City, UT: Amirsys.
Noffsinger, A. (2007). Gastrointestinal diseases. Atlas of non tumour pathology. Washington, DC: American Registry of Pathology.
Odze, R. (2009). Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia, PA: Saunders Elsevier.
Zarovnaya, E. (2005). Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Archives of Pathology & Laboratory Medicine, 129, 1032–1036.
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Fonseca, R., Chaves, P. (2017). Pseudoepitheliomatous Hyperplasia, Esophageal. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1673
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1673
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