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Basaloid Squamous Cell Carcinoma, Esophageal

  • Reference work entry
  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

  • 181 Accesses

Synonyms

There are no current synonyms for this neoplasm. Historically, it has been confused with another neoplastic entity, namely adenoid cystic carcinoma.

Definition

A malignant epithelial neoplasm composed of closely packed cells with hyperchromatic nuclei and scant cytoplasm, with a solid growth pattern, small cystic spaces, and foci of necrosis. The diagnosis depends on the demonstration of squamous cell dysplasia/carcinoma in situ in the overlying mucosa.

Clinical Features

  • Incidence

    Basaloid squamous cell carcinoma (BSCC) is a rare entity and there are no global worldwide incidence data available. In most published series, the incidence ranges from 0.07% to 11.3% of all esophageal carcinomas.

  • Age

    In the published series, the mean age at the time of diagnosis is around 60 years.

  • Sex

    There is a slight predominance in males.

  • Site

    This type of neoplasm has been classically described in the upper aerodigestive tract, namely at the larynx and the esophagus, but it can also be...

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References and Further Reading

  • Chen, S.-B., Weng, H.-R., Wang, G., Yang, W.-P., Li, H., Liu, D.-T., & Chen, Y.-P. (2012). Basaloid squamous cell carcinoma of the esophagus. Journal of Cancer Research and Clinical Oncology, 138(7), 1165–1171.

    Article  Google Scholar 

  • Imamhasan, A., Mitomi, H., Saito, T., Hayashi, T., Takahashi, M., Kajiyama, Y., & Yao, T. (2012). Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. Human Pathology, 43(11), 2012–2023.

    Article  CAS  Google Scholar 

  • Sarbia, M., Verreet, P., Bittinger, F., Dutkowski, P., Heep, H., Willers, R., & Gabbert, H. E. (1997). Basaloid squamous cell carcinoma of the esophagus – Diagnosis and prognosis. Cancer, 79(10), 1871–1878.

    Article  CAS  Google Scholar 

  • Zhang, X.-H., Sun, G.-Q., Zhou, X.-J., Guo, H.-F., & Zhang, T.-H. (1998). Basaloid squamous carcinoma of esophagus: A clinicopathological, immunohistochemical and electron microscopic study of sixteen cases. World Journal of Gastroenterology, 4(5), 397–403.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

    Maria Gabriela Gasparinho

  2. Instituto de Anatomia Patológica da Faculdade de Ciências da Saúde da Universidade da Beira Interior, Covilhã, Portugal

    Maria Gabriela Gasparinho

  3. Serviço de Anatomia Patológica, Instituto Português de Oncologia Francisco Gentil – Lisboa, Lisbon, Portugal

    Isabel Fonseca

  4. Faculdade de Medicina de Lisboa, Instituto de Anatomia Patológica, Lisbon, Portugal

    Isabel Fonseca

Authors
  1. Maria Gabriela Gasparinho
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  2. Isabel Fonseca
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Corresponding author

Correspondence to Maria Gabriela Gasparinho .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Gasparinho, M.G., Fonseca, I. (2017). Basaloid Squamous Cell Carcinoma, Esophageal. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1565

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1565

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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