Synonyms
Regional enteritis, ileitis terminalis (the first name used in the original paper by Dr. Burrill Crohn and colleagues)
Definition
Crohn’s disease is a life-long relapsing inflammatory disease of unknown aetiology, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. The disease can involve different segments of the gastrointestinal tract. Various theories have been proposed for the pathogenesis of Crohn’s disease with implications for specific therapies. Genome-wide association studies identified susceptibility loci that, triggered by environmental factors, may result in a disturbed innate and adaptive immune response. Dysfunction of innate immunity includes a disturbed intestinal barrier, Paneth cell dysfunction, endoplasmic reticulum stress, defective unfolded protein response and autophagy, impaired recognition of microbes by pattern recognition receptors, such as nucleotide-binding domain and Toll-like receptors...
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Geboes, K. (2017). Crohn’s Disease. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1450
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1450
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-40560-5
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