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Neurodegenerative Disorders

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Geriatric Diseases

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Abstract

Alzheimer’s disease primarily a neurodegenerative disorder is the commonest cause of dementia followed by vascular dementia. Alzheimer’s disease is a disorder of the amyloid precursor protein (APP), the frontotemporal (FTD) syndromes and some of the extrapyramidal dementias (corticobasal, progressive supranuclear palsy) are associated with the microtubule – associated protein tau. Other degenerative diseases including Parkinson’s disease, multiple system disease and Lewy Body dementia are associated with a – synuclein. The review provides an overview of the neyodegenerative dementias.

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References

Neurodegenerative Dementias

  1. Launer LG, Anderson K, Dewey ME, Letenneur L, Ott A, Amaducci LA, et al., Rates and risk factors for dementia and Alzheimer’s disease: results from EURODERM pooled analyses. EURODERM . Incidence Research Group and Work Gropus. European Studies of Dementia. Neurology. 1999;52:78–84.

    Article  CAS  PubMed  Google Scholar 

  2. Rockwood K, Wentzel C, Hachinski V, Hogan DB, MacKnight C, McDowell I. Prevalence and outcomes of vascular cognitive impairment. Neurology. 2000;54:447–451.

    Article  CAS  PubMed  Google Scholar 

  3. Ragon S, Lippa CF. Alzheimer’s and other dementias : A review. Am J Alz Dis Other Disord. 2002; 17: 11–17.

    Article  Google Scholar 

  4. Tolnay M, Prost A. The neuropthological spectrum of neurodegenerative tauopathies. IUBMB Life. 2003;55(6):299–305.

    Article  CAS  PubMed  Google Scholar 

Alzheimer’s Disease

  1. Goedert M. Filamentous nerve cell inclusions in neurodegenerative diseases: taupathies and alpha-synucleinopathies. Philos Trans R Soc Lond B Biol Sci. 1999;354(1386):1101–18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Kowlaska A. The genetics of dementias. Part 1: Molecular basis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Postepy Hig Med Dosw (Online) 2009;63:278–86.

    Google Scholar 

  3. Morris HR, Lees AJ, Wood NW. Neurofibrillay tangle parkinsonian disorders-tau pathology and tau genetics. Mov Disord. 1999;14:731–36.

    Article  CAS  PubMed  Google Scholar 

  4. McKeith IG, Burn DJ, Ballard CG, Collerton D, Joros E, Morris CM, et al. Dementia with Lewy bodies. Semin Clin Neuropsychiatry 2003;8(1):46–57.

    Article  PubMed  Google Scholar 

  5. Alzheimer’s Australia. Diagnostic criteria for Dementia, 2016, pp1–6.disease. facts and figures.

    Google Scholar 

  6. Berchtold NC, Cotman CW. Evolution in the conceptualisation of dementia and Alzheimer’s : Greco-Roma period to the 1960s. Neurobiol Aging. 1998;19(3):173–89.

    Article  CAS  PubMed  Google Scholar 

  7. Manyam BV. Dementia in Ayurveda. J Altern Complemet Med. 1999;5(1)81–8.

    Article  CAS  Google Scholar 

  8. Hippius H, Neundofer G. The discovery of Alzheimer’s disease. Dialogues Clin Neurosci .2003;5:101–108.

    PubMed  PubMed Central  Google Scholar 

  9. Ramirez-Bermudez. Alzhemer’s disease: critical notes on the history of a medical concept. Arch Med Res. 2012;43(8):595–9.

    Article  PubMed  Google Scholar 

  10. Derouesne C. Alzheimer and Alzheimer’s diseae: the present enlighted by the pat. An historical past. Psychol Neuropsychiayr Vieil. 2008;6, 2:115–28.

    Google Scholar 

  11. Hebert LE,Scherr PA, McCann JJ, et al. Is the risk of developing Alzheimer’s disease greater for women than for men? Amer J Epidem 2001;153:132–136.

    Article  CAS  Google Scholar 

  12. Johnson GV, Stoothoff WH. Tau phosphorylation inneuronal function and dysfunction. J Cell Sci. 2004;117(Pt2):5721–5729.

    Article  CAS  PubMed  Google Scholar 

  13. Lindwall G, Cole RD. Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem. 1984;259:5301–5305.

    CAS  PubMed  Google Scholar 

  14. Duan Y, Dong S, Gu F, Hu Y, Zhao Z. Advances in the pathogenesis of Alzheimer’sdisease: focussing on tau-mediated neurodegeneration. Transl Degener. 2012;15(1):24.

    Google Scholar 

  15. Meraz-Rios MA, Lira-De Leon KL, Campos-Pena V, de Anda-Hernande MA, Mena-Lopez R. Tau oligomers and aggregation inAlzheimer’s disease. J Neurochem. 2010;112:1353–67.

    Article  CAS  PubMed  Google Scholar 

  16. Aprahamian I, Stella F, Forlenza OV. New treatment strategies for Alzheimer’s disease:is there hope? Ind J Med Res. 2013;138:449–460.

    CAS  Google Scholar 

  17. Pei JJ,Braak E, Braak H, Grunke-Iqbal I, Iqbal K,Winbold B, et al. Distribution of active glycogen synthase kinase 3 beta (GZSK-3beta) in brains stages for Alzheimer disease neurofibrillary tangles. J Neuropathol Exp Neurol. 1999;58:1010–9.

    Article  CAS  PubMed  Google Scholar 

  18. Octave JN. Alzheimer disease:cellular and molecular aspects. Bull Mem Acad R Med Belg 2005;160(10–12):445–9.

    CAS  PubMed  Google Scholar 

  19. de Paula VJR, Guimaraes FM, Diniz BS, Forlenza OV. Neurobiological pathways to Alzheimer’s disease. Dementia Neuropsychologia. 2009;3(3):188–194.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Dong S,Duan Y, Hu Y, Zhao Z. Advances in the pathogenesis of Alzheimer’s disease : a re-evaluation of amyloid cascade hypothesis. Transl Neurodegener. 2012;1:18. https://doi.org/10.1186/2047-9158-1-18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Hardy J. Alzheimer’s disease: the amyloid cascade hypothesis :an update and reappraisal. J Alz Dis. 2006;9:151–153.

    CAS  Google Scholar 

  22. Kuzuhara S. Treatment strategy of Alzheimer’s disease:pause in clinical trials of Abeta vaccine and next steps. Brain Nerve. 2010;62(7):659–66.

    PubMed  Google Scholar 

  23. Rao AT, Degnan AJ, Levy LM. Genetics of Alzheimer Disease. ANJR Am J Neuroradiol. 2014; 1–2.

    Google Scholar 

  24. Duyckaerts C, Perruchini C, Lebouvier T, Potier MC. The lesions of Alzheimer’s diseae:which therapeutic perspectives? Bull Acad Natl Med. 2008;192(2):303–18.

    CAS  PubMed  Google Scholar 

  25. Chui HC, Teng EL, Henderson VW, Moy AC. Clinical subtypes of the Alzheimer type. Neurology. 1986;35:1544–1560.

    Article  Google Scholar 

  26. Palasi A, Iglesias BG, Alegret M, Pujadas F, Olabarrieta M, Liebana D, et al. Differentiated clinical presentation of early and late onset Alzheimer’s disease: is 65 yars of age providing a relationship threshold. J Neurol. 2015;20(5):1238–1246.

    Article  CAS  Google Scholar 

  27. Price DL, Sisodia SS. Mutant genes in familial Alzheimer’s disease and transgenic models. Annu Rev Neurosci. 1998;21:479–505.

    Article  CAS  PubMed  Google Scholar 

  28. Lendon CL, Marinez A, Behrens I, Kosik KS,Madrigal L, Norton J, et al. L280A PS-1 mutation causes Alzheimer’s diseaae but age of onset is modified by ApoE –alleles. Human Mutaz. 1997;10:186–195.

    Article  CAS  Google Scholar 

  29. Williamson J, Goldman J, Marder KS. Genetic aspects of Alzheimer’s disease. Neurologist. 2009;15:80–86.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Hoernicka J. Genes in Alzheimer’s disease. Rev Neurol. 2006;42(5):302–5.

    Google Scholar 

  31. Bekris LM,Yu CE, Bird TD, Tsuang DW. Genetics of Alzheimer’s disease. J Geriatr Psychiatry Neurol. 2010;23:213–27.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Crystal HA, Horoupian DS, Katzman R, Jotkowitz S. Biopsy-proved Alzheimer disease presenting as a right parietal lobe syndrome. Ann Neurol. 1982;12:186–188,

    Article  CAS  PubMed  Google Scholar 

  33. Faden AI, Townsend JJ. Myoclonus in Alzheimer’s disease. Arch Neurol. 1976;33:278

    Article  CAS  PubMed  Google Scholar 

  34. Jagust WJ, Davies P, Tiller-Borcich JK, Reed BR. Focal Alzheimer’s disease. Neurology. 1990;40:14–19.

    Article  CAS  PubMed  Google Scholar 

  35. Seltzer H, Sherwin I. A comparison of clinical features in early and late-onset primary degenerative dementia: one entity or two? Arch Neurol. 1983;40:143–146.

    Article  CAS  PubMed  Google Scholar 

  36. Raskind MA, Carta A, Bravi D. In early-onset Alzheimer disease a distinct subgroup with the Alzheimer disease population. Alz Dis Ass Disord. 1995;9: Suppl 1 pp S2–S6.

    Google Scholar 

  37. Pearce J. The exrapyramidal disorder in Alzheimer’s disease. Eur Neurol. 1974;12:94–103.

    Article  CAS  PubMed  Google Scholar 

  38. Molsa PK, Marttila RJ, Rinne UK. Extrapyramidal signs in Alzheimer’s disease. Neurology. 1984;34:1114–1116.

    Article  CAS  PubMed  Google Scholar 

  39. Mayeux R, Stern Y, Spanton S. Heterogeneity in dementia of the Alzheimer type: Evidence of subgroups. Neurology. 1985;35:453–461.

    Article  CAS  PubMed  Google Scholar 

  40. Sa F, Pinto P,Cunha C, Santana I. Differences between early and late-onset Alzheimer’s disease. Front Neurol. 2012;3:81. https://doi.org/10.3389/fneur.2012.00081.eC.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Panza F, Solfrizzi V, D’Introno A, Capurso C, Colacicco AM, Torres F, et al. PGenetics of late-onset Alzheimer’s disease: vascular risk and beta-amyloid metabolism. Recenti Prog Med. 2002;93(9):489–97.

    PubMed  Google Scholar 

  42. Devi G, Willamson J, Masssoud F, Anderson K Stern Y, Devsnand D, et al. A comparison of family history of psychiatric disorders among patients with early and late-onset Alzheimer’s disease. J Neuropsychiatry Clin Sci. 2014;16:57–62.

    Article  Google Scholar 

  43. Iversen LL. Differences between early and late –onset Alzheimer’s disease. Neurobiol Aging. 1987;6(6):554–555.

    Article  Google Scholar 

Hippocampal Sclerosis with Aging

  1. Nelson PT, Smith CD, Abner EL, Wilfred BJ, Wang WX, Neltner JH, et al. Hippocampal sclerosis of aging,a prevalent and high-morbidity brain disease. Acta Neuropathol. 2013;126(2):161–177.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Ighodaro ET, Jicha GA, Schmitt FA, Neltner JH, Abner EL, Kryscio RJ, et al. Hippocampal sclerosis of aging can be segmental: two cases and review of the literature. J Neuropathol Exp Neurol. 2015;74(7):642–652.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Nag S, Yu L, Capuano TW, Wilson RS, Leurgano SE, Bentt DA, Schneider JA. Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer’s disease. Annal Neurol. 2015;77(6):942–952.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Neltner JH, Abner EL, Jicha GA, Schmitt FA, Patel E, Poon LW, et al. Brain pathologies in extreme old age. Neurobiol Aging. 2016;37:1–11.

    Article  PubMed  Google Scholar 

  5. Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT. Hippocampal sclerosis of aging is a key Alzheimer’s diseae mimic: clinicapathologic corrrelations and comparisons wuth both Alzheimer’s disease and non-taupathc frontotemporal lobar degeneration. J Alzheimers Dis. 2014;39(3):691–702.

    PubMed  PubMed Central  Google Scholar 

  6. Cykowski TH, Van Eldik KLJ, Schitt FA, Jicha GA, Poell CS, Nelson PT. Hippocampal sclerosis but not norml aging or Alzheimer’s disease is associated with TDP-43 in the basa forebrain of aged patients. J Neuropathol Exp Neurol. 2016. www.docphin.com/research/article-detail/18355962/Pub Med - 26971127/Hippocampal sclerosis.

Fronto-temporal Dementia

  1. Kertesz A, Munoz DG. Primary progressive aphasia: a review of the neurobiology of a common presentation of Pick Complex. Am J Alz Dis other Disord. 2002;17:30–36.

    Article  Google Scholar 

  2. Bak TH, Hodges JR. Motor neurone disease, dementia and aphasia: Coincidence, co-occurrence or continuum? J Neurol. 2001;248:260–70.

    Article  CAS  PubMed  Google Scholar 

  3. Kertesz A, Blair M, McMonagle P, Munoz DG. The diagnosis and course of frontotemporal dementia. Alz Dis Assoc Disord. 2007;21:155–63.

    Article  Google Scholar 

  4. Chow TW, Miller BL, Hayashi VN, Geschwind DH. Inheritance of frontotemporal dementia. Arch Neurol. 1999;56:817–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Goldman JS, Farmer JM, Wood EM, Johnson JK, Boxer A, Neuhaus J, et al. Compasrison of family histories in FTLD subtypes and related tauopathies. Neurology. 2005;65:1817–9.

    Article  CAS  PubMed  Google Scholar 

  6. Seelar H, Rojrer JD, Pijnenburg YA, Fox NC, Swieten JC. Clinical genrtic and pathological heterpgenity of frontotemporal dementa: a review. J Neurol Neurosurg Psychiatry. 2011;82:476–486.

    Article  Google Scholar 

  7. Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: Consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol. 2007;114:5–22.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Bigio EH. Update on recent molecular and genetic advances in frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2008;67:635–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Mackenzie IR. The neuropathology of FTD associated with ALS. Alzheimer Dis Assoc Disord. 2007;21(4):S44–9.

    Article  PubMed  Google Scholar 

  10. Arai T, Hosokawa M, Hasegawa M, Akiyama H, Asada T. A new demntia gropu caused by TDP-43 abnormality. Seishin Shinkeigaku Zasshi. 2011;113(6):574–83.

    PubMed  Google Scholar 

  11. Wilson AC, Dugger BN, Dickson DW, Wang DS. TDP-43 in aging and Alzheimer’s disease. a review. Int J Clin Exp Pathol. 2011;4(2):147–55.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Neary D, Snowden JS, Gustsfson L,Pasant U, Stuss D, Black S, et al. Frontotemporal lobar degeneration. A consensus on clinical diagnostic criteria. Neurology. 1998;51:1546–54,

    Article  CAS  PubMed  Google Scholar 

  13. Nagaratnam N, Nagaratnam K. Slowly progressive aphasia heralding dementia. Am J Alz Dis Other Disord. 1997;12(6):245–251.

    Google Scholar 

  14. Hodges JR, Patterson K, Oxbuy S, Funnell E.Semantic dementia. Progresssive fluent aphasia with temporal lobe atrophy. Brain. 1992;115:173–806.

    Article  Google Scholar 

  15. Ash S, Moore P, Vesely L, Gunaardene D, McMillan C, Aderson C, Avants B, Grossman M. Non-fluent speech in frontotemporal lobar degeneration. J Neurolinguistics. 2009;22:370–83.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A, et al. The logopenic/phonological variant of primary progressive aphasia. Neurology. 2008;71:1227–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, et al. Cognition and anatomy in three variants of prmary progressive aphasia. Ann Neurol. 2004;55:335–46.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Mesulam M, Wicklund A, Johnson N, Rogalski E, Leger GC, Rademaker A, et al. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol. 2008;63:709–19.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Leyton CE, Hodges JR. Frontotemporal dementias: Recent advances and current controversies. Ann Ind Acad Neurol. 2010;13(6):74–80.

    Article  Google Scholar 

  20. Neary D, Snowden JS, Mann DM, Northen B, Goulding PJ, Macdermott N. Frontal lobe dementia and motor neurone disease. J Neurol Neurosurg Psychiatry. 1990;53:23–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Nagaratnam N, Cheuk G, Nagaratnam K. Slowly progressive aphasia with striatal involvement. Am J Alz Dis Other Disord. 2002;17:18–22.

    Article  Google Scholar 

Cortico-basal Degeneration

  1. Togaski DM, Tanner CM. Epidemiologic aspects. Adv Neurol. 2000;82:53–59.

    Google Scholar 

  2. Wenning GK, Litvan PJ, Jankovics J, Granata R, Mangone CA, McKee A, et al. Natural history and survival of 14 patients with corticobasal degeneration. J Neurol Neurosurg Psychiatry. 1998;64:184–189.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Dickson DW, Liu WR, Ksiezak-Reding H ,Yin SH. Neuropatholical and molecular considerations. Adv Neurol. 2000;82:9–27.

    CAS  PubMed  Google Scholar 

  4. Mahapatra RK, Edwards MJ, Schott JM, Bhatia KP. Corticobasal degeneration. Lancet. 2004;3:736–43 .

    Article  PubMed  Google Scholar 

  5. Kertsz A, Martinez-Lage P, Davidson W, Munoz DG. The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology. 2000;55:1368–1375.

    Article  Google Scholar 

  6. Boeve BF, Lang AE, Litvan I. Corticobasal degeneration and its relationship to progteive supranuclear palsy and frontotemporal dementia. Ann Neurol. 2003;54(supl 5):S15–S19.

    Article  PubMed  Google Scholar 

  7. Rinne JO, Lee MS, Thompson PD, Marsden CD. Corticobasal degeneration : a clinical study of 36 cases. Brain. 1994;117:1183–96.

    Article  PubMed  Google Scholar 

  8. Riley DE, Lang DE, Lewis A, Resch L, Ashby P, Hornykiewicz O,et al. Cortico-basal ganglionic degeneration. Neurology. 1990;40(8):1203–1212.

    Article  CAS  PubMed  Google Scholar 

  9. Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathological concepts and diagnostic chalege. Lancet Neurol. 2009;8:270–279.

    Article  PubMed  Google Scholar 

Posterior Cortical Atrophy

  1. Crutch SJ , Schott JM , Rabinovici GD, Boeve BF, Cappa SF, Dickerson BC, et al. Shining a light on posterior cortical atrophy Alzheimer’s & Dementia. 2013;1–3.

    Google Scholar 

  2. Benson DF, Davis RJ, Synder BD. Posterior cortical atrophy. Arch Neurol. 1988;45:789–793.

    Article  CAS  PubMed  Google Scholar 

  3. Croisile B. Benson’s syndrome or posterior cortical atrophy. Orphanet EncyclopediaSeptember 2004. http://www.orpha.net/data/patho/GB/uk-Benson.pdf retreived 24 March 2014.

  4. Lehmann M,Crutsh SJ,Ridgeway GR, Ridha BH, Barnes J, Warrington RK,et al. Cortical thickness and voxed –based morphometry in posterior cortical atrophy atypical Alzheimmer’s disease. Neurobiol Aging 2009. https://doi.org/10.1016/jneurobiolaging.2009.08.017.

  5. Vernooij MW, de Groot M, van der Lugt A, Ikram M, Hrestin G, et al. White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging. Neuroimage. 2008; 43(3):470–7.

    Article  CAS  PubMed  Google Scholar 

  6. Gerabrowski TJ, Damasio AR. Definition clinical features and neuroanatomical basis of dementia. The Neuropathology of Dementia. 2nd ed. Esirl Maragaret M, Virginia M, Y Lee and John Q Trojancwski. Published by Cambridge University Press. Cambridge University Press, 2004.

    Google Scholar 

  7. Vighetto A, Krolak-Salmon P. Balint syndrome in The Behavioral and Cognitive Neurology of Stroke. 2nd Ed Alan Vighetto, Pierre Krolak-Salmon Cambridge University Press. 2013. Pp 218–230.

    Google Scholar 

  8. Midorikawa A. Clinical characteristics of posteriorcortical atrophy. Brain Nerve. 2010;62(7):727–735.

    PubMed  Google Scholar 

Lewy Body Dementia

  1. Barber R, Panikkar A, McKeith IG. Dementia with Lewy bodies: diagnosis and management. Int J Geriatr Psychiatry. 2001;Suppl 1 S12–8.

    Google Scholar 

  2. Arsland D. Dementia with Lewy bodies. Tidsskr Nor Laegeforen. 2002;122(5):525–9 .

    PubMed  Google Scholar 

  3. Dickson DW. Dementia with Lewy bodies: neuropathology. J Geriatr Psychiatry Neurol. 2002;15(4):210–6.

    Article  PubMed  Google Scholar 

  4. Gibb WRG, Luthert PJ, Janota I, Lantos PL. Cortical Lewy body dementia: clinical features and classification. J Neurol Neurosurg Psychiatry. 1989;52:185–192.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. McKeith IG, Fairbairn AF, Perry RH, Thompson P, Perry E. Neuroleptic sensitivity in patients with senile dementia of the Lewy body type. Br Med J. 1992;305:673–678.

    Article  CAS  Google Scholar 

  6. Klatka LA, Louis ED, Schiffer RB. Psychiatric features in diffuse Lewy body disease: a clinico-pathologic study using Alzheimer’s disease. and Parkinson’s disease comparison groups. Neurology. 1996;47:1148–1152.

    Article  CAS  PubMed  Google Scholar 

  7. McKeith IG, Galaska D, Kosaka K, Perry EK,Dickson DW, Hansen A, et al. 1996. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB International workshop. Neurology. 1998; 47:1113–1124.

    Google Scholar 

Parkinson’s Disease and Dementia

  1. Wang HS. Dementia in old age. In: Dementia. Second edition. Ed. by CE Wells. Philadelphia FA. Davis p 15–26,1977.

    Google Scholar 

  2. Henderson AS, Kay D. The epidemiology of mental disorders in the aged. In: Handbook of studies on psychiatry and old age. ed. by DWK Kay and GD Burrows. Amsterdam. Elsevier pp 53–88,1984.

    Google Scholar 

  3. Gibbs WRG. Dementia and Parkinson’s disease. J Psychiatry. 1989;154:596–614

    Article  Google Scholar 

  4. Hakim AM, Matheison G. Dementia in Parkinson’s disease: a neuropathological study. Neurology. 1979;29:1219–1214.

    Article  Google Scholar 

  5. Brown RG, Marsden CD. How common is dementia in Parkinson’s disease? Lancet. 1984;ii:1262–1265.

    Google Scholar 

  6. Lees AJ. Parkinson’s disease and dementia. Lancet. 1985;i:43–44.

    Article  Google Scholar 

Vacular Cognitive Impairment

  1. Hennerici MG. What are the mechanisms for post stroke dementia? The Lancet Neurology. 2009;8(11):973–975.

    Article  PubMed  Google Scholar 

  2. Roman GC, Sachdev P, Royall DR, Bullock RA, Orgogozo JM, Lopez-Pousa S, et al. Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia. J Neurol Sci. 2004; 226 (1–2):81–7.

    Article  PubMed  Google Scholar 

  3. Jellinger KA. Pathology and pathogenesis of vascular cognitive impairment –a critical update. Front Aging Neurosci. 2013;5:17. https://doi.org/10.3389/fnagi.2013.0017.eCol

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Black SE. Therapeutic issues in vascular dementia: studies designs and approaches. Can J Neurol Sci. 2007;34 Suppl 1:S125–30.

    Article  PubMed  Google Scholar 

  5. Rockwood K,Wentzel C, Hachinski V, Hogan DB, MacKnight C, McDowell I. Prevalence and outcomes of vascular cognitive impsirment. Neurology. 2000,54:447–54.

    Article  CAS  PubMed  Google Scholar 

  6. Ingles JL, Wenztel C, Fisk JD, Rockwood K. Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment,without dementia. Stroke. 2002;33:1999–2002.

    Article  PubMed  Google Scholar 

  7. Erkinjuntti T, Gauthier S. The concept of vascular cognitive impairment. Front Neurol Neurosci. 2009;24:79–85.

    Article  PubMed  Google Scholar 

  8. Sachdev P, Royall DR, Bullock RA, Orgogozo JM, Lopez-Pousa S, Arizaga R, et al. Vascular cognitive disorder (VCD). 1999;14:402–403.

    Google Scholar 

  9. Jellinger KA. Pathology and pathophysiology of vascular cognitive impairet. A critical update. Panminerva Med. 2004;46(4):217–26.

    CAS  PubMed  Google Scholar 

  10. Knopman DS, Parisi JE, Boeve BF, Cha RH, Apaydin H, Salviati A, et al. Vascular dementia in a population-based autopsy study. Arch Neurol. 2003;60:569–75.

    Article  PubMed  Google Scholar 

  11. Bowler JV. Vascular cognitive impairment. J Neurol Neuosurg Psychiatry. 2005;76(SupplV):v35–v55. https://doi.org/10.1136/jnnp.2005.082313.

  12. Gorelick PB. Status of risk factors for dementia associated with stroke. Stroke. 1997;28:459–463.

    Article  CAS  PubMed  Google Scholar 

  13. Shinkawa A, Ueda K, Kiyphara Y, Kato I, Sueishi K, Tsuneyoshi M, et al. Silent cerebral infarction in a community –based autopsy series in Japan.Stroke. 1995;26:380–385.

    Article  CAS  PubMed  Google Scholar 

  14. Ricci S, Celani MG, La Rosa F, Righetti E, Duca E, Capito N. Silent brain infarction in patients with first-ever stroke: a community based study in Umbera, Italy. Stroke 1993;24:647–651.

    Article  CAS  PubMed  Google Scholar 

  15. Nagaratnam N, Bou-Haidar P, Leung H. Confusion and disturbed behaviour in the elderly following silent frontal infarction. Amer J Az Dis. 2003;18:333–339.

    Google Scholar 

  16. Hachinski VC, Llif LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, et al.. Cerebral blood flow in dementia. Arch Neurol. 1975;32:632–637.

    Article  CAS  PubMed  Google Scholar 

  17. Chui HC, Victoroff J, Margolin D, Jagust W, Shankle R, Katzman R. Criteria for the diagnosis of ischaemic vascular dementia proposed by the state of California Alzheiner’s Disease Diagnostic and Treatment Centers. Neurology. 1992;42:473–480.

    Article  CAS  PubMed  Google Scholar 

  18. Wetterling T, Kanitz RD, Borgis JK. Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN) Stroke 1996;21;30–35.

    Article  Google Scholar 

  19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th ed) (DSM-IV). Washington DC. American Psychiatric Association.1994.

    Google Scholar 

  20. World Health Organisation. The ICD-10 Classification of Mental and Behavioural Disorders. Clinical description and diagnostic guidelines. Geneva. Switzerland. World Health Organisation. 1992 50–51.

    Google Scholar 

  21. Roman GC, Tatwmichi TK, Erkinjunthi T, Cummngs JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993;43(2):250–60.

    Article  CAS  PubMed  Google Scholar 

  22. Censori B, Manara O, Agostinis C, Camerlingo M, Casto L, Galavotti B,et al. Dementia after first stroke. Stroke. 1996;27:1205–1210.

    Article  CAS  PubMed  Google Scholar 

  23. Jorm AF, Korten AE. Assessment of cognitive decline in the elderlyby informant interview. Br J Psychiatry. 1988;152:209–215.

    Article  CAS  PubMed  Google Scholar 

  24. Henderson AS, Huppet FA. The problem of mild dementia. Psychol Med.1984;14:5–11.

    Article  CAS  PubMed  Google Scholar 

  25. Nagaratnam N, McNeil C. Dementia in the severely aphasic: global aphasia without hemiparesis-a stroke subtype simulating dementia. Amer J Alz Dis. 1999, 14:74–78.

    Google Scholar 

  26. Erkinjuntti T, Kurz A, Gauthier S, Bullock R, Lilienfeld S, Damaraju V. Efficacy of galantamine in probable vascular dementia and Alzheimer’s disease combined with cerebrovascular disease. The Lancet. 2002;359: 1283–90.

    Article  Google Scholar 

CJD

  1. Masters CL, Harris OA, Carleton Gajdusck D, Gibbs CJ, Jr, Bernoulli C, Asher DM. Cruetzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol. 1979;5:177–188.

    Article  CAS  PubMed  Google Scholar 

  2. Right diagnosis. Statistics about Creutzfeldt-Jakob Disease. http://www.rightdiagnosis.com/c/creutzfeldt_jakob_disease/states.htm retrieved 1 June 2014.

  3. Bruton CJ, Bruton RK, Gentleman SM, Roberts GW. Diagnosis and incidence of prion (CJ) Disease: A retrospective archival study with implications for future research. Neurodegneration. 1995;4(4):357–368.

    Article  CAS  Google Scholar 

  4. Pan KM, Baldwin M, Nguyen I, Gasset M, Serban A, Groth D, et al. Conversion of a helices into b –sheets features in the formation of the scrapie prion proteins. Proc.Natl Acad Sci. USA.1993;90:10962–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zerr I, Poser S. Epidemiology and risk factors of transmissible spongiform encephalopathies in man. Prions. 2001;7:93–104.

    Article  CAS  Google Scholar 

  6. UCSF. http://memory.uscf.edu/cjd/overview/symptoms retrieved 30 September 2013.

  7. Alz.org. http://www.alz.org/dementia/creutzfeldt-jakob-disease-cjd-symptoms.asp. retreived 30 September 2013.

  8. Gambetti P, Kong Q, Zou W, Parchi P, Chen SC. Sporadic and familial CJD; classification and characteristics. Brit Med Bull. 2003;66(1):213–239.

    Article  CAS  PubMed  Google Scholar 

  9. Brown P, Brandel J-P, Sato T, Nakamura Y, MacKenzie J, Wills RG, et al. Iatrogenic Creutzfeldt-Jakob disease. Final Assessment. Emerg Infect Dis. 2012;18(6):901–907.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Wieser HG, Schindler K, Zumstig D. EEG in Creutzfeldt-Jakob disease. Clin Neurophysiol 2006;117(5):935–951.

    Article  PubMed  Google Scholar 

  11. Hsich G, Kenny K,Gibbs CJ Jr, Lee H, Harrington MG. The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopatthies. NEJM. 1996;335:924–930.

    Article  CAS  PubMed  Google Scholar 

  12. Poser S, Mollenhauer B, Kraub A, Zerr I, Steinhoff BJ, Schroeter A, et al. How to improve the clinical diagnoss of Creutzfeld-Jakob disease. Brain. 1999;122:2345–2351.

    Article  PubMed  Google Scholar 

AIDs Dementia Complex

  1. Christo PP. Cognitive alterations associated with HIV-1 infection and AIDS. Rev Assoc Med Bras. 2010;56(2):242–7.

    Article  PubMed  Google Scholar 

  2. Ances BM, Ellis RJ. Dementia and neurocognitive disorders due toHIV-1 infection. Semin Neurol. 2007;27(1):86–92.

    Article  PubMed  Google Scholar 

  3. Del Palacio M, Alvarez S, Munoz-Fernandez MA. HIV-1 infection and neurocognitive impairment in the current era. Rev Med Virol. 2012;22(1):33–45.

    Article  PubMed  Google Scholar 

  4. Brooks JT, Buchacz K, Gebo KA, Mermin J. HIV infection and older Americans: The Public Health Perspective. Am J Public Health. 2012;102(8):1516–1526.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Watkins CC, Treisman GJ. Cognitive impairment in patient with AIDS-prevalence and severity. HIV AIDS (Auckl). 2015:7:35–47. https://doi.org/10.2147/HIV.S396665.

    PubMed  PubMed Central  Google Scholar 

  6. Fauci AS, Lane HC. Human immunodeficiency virus (HIV) disease AIDS and related disorders IN AS Fauci, E Braunwald, KJ Isselbacher, J Wilson, JB Martin, DL Kasper SL Hauser and DL Longo (Eds) Harrison’s Principles of Internal Medicine, New York NY: McGran-Hill.,1998.

    Google Scholar 

  7. Holman BL, Devous MD Sr. Functional brain SPECT. The emergence of a powerful clinical method. J Nuclear Med. 1992;33:1888–1904.

    CAS  Google Scholar 

Normal Pressure Hydrocephalus

  1. Brean A, Eide PK. Prevalence of probable normal pressure hydrocephalus in a Norwegian population. Acta Neurol Scand. 2008;118(1):48–53.

    Article  CAS  PubMed  Google Scholar 

  2. Mamarou A, Young HF, Aygoh GA. Estimated incidence of normal pressure hydrocephalus and shunt outcome in patients residing in assisted living and extended care facilities. Neurosurg Focus. 2007;22(4):E1.

    Article  Google Scholar 

  3. Juge L. The diagnosis of normal pressure hydrocephalus and other diseases that cause ventricular dilatation. Neuroscience Research ,Australia.2014. brainfoundation.org.au/wp-contents/up;oads/2015’05/Juge-Lauriane-Normal-Pressure-Hydrocephalus.pdf.

  4. Krauss JK, Halve B. Normal pressure hydrocephalus : survey on contemporary diagnostic algorithms and therapeutic decision-making in clinical practice. Acta Neurochir (Wien). 2004;146(4):379–88.

    Article  CAS  PubMed  Google Scholar 

  5. Hakim S, Adams RD. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinalfluid pressue. Observations on cerebrospinal fuid hydrodynamics. J Neurol Sci. 1965;2(4):307–11.

    Article  CAS  PubMed  Google Scholar 

  6. Conner ES, Foley L, Black PM. Experimental normal –pressure hydrocephalus is accompanied by increased transmantle pressure. J Neurosurg. 1984;61(2):322–7.

    Article  CAS  PubMed  Google Scholar 

  7. Vassilouthis J. The syndrome of normal-pressure hydrocephalus. L Neurosurg 1984;61:501–509.

    Article  CAS  Google Scholar 

  8. Krauss IK, Regel IP. The predictive value of ventricular CSF removal in normal pressure hydrocephalus. Neurol Res.1997;19:357–360.

    Article  CAS  PubMed  Google Scholar 

  9. Bradley WG. Normal pressure hydrocephalus: New concepts on etiology and diagnosis. ANJR. 2000;21:1586–1590.

    CAS  Google Scholar 

  10. Hakim S,Vengas JG, Burton JD. The physics of the cranial cavity, hydrocephalus and normal pressure hydrocephalus: mechanical interpretation and mathematical model. Surg Neurol. 1970;5:187.

    Google Scholar 

  11. Graff-Radford NR, Godersky JC. Idiopathic normal hydrocephalus and systemic hypertension. Neurology. 1987;37:868–871.

    Article  CAS  PubMed  Google Scholar 

  12. Casmiro M, D’Alessandro R, Cacciatore FM, Daidone R, Calbuci F, Lugaresi E. Risk factors for the syndrome of ventricular enlargement with gait apraxia (idiopathic) normal pressure hydrocephalus:a case-control study. J Neurol Neurosurg Psychiatry. 1989;52:847–852.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bateman GA. The pathophysiology of idiopathic normal pressure hydrocephalus: cerebral ischaemia or altered venous hemodynamics. AJNR Am J Neuroradiol. 2008;29:198–203.

    Article  CAS  PubMed  Google Scholar 

  14. Mathew NT, Meyer JS, Hartman A, Otto EO. Abnormal cerebrospinal fluid –blood flow dynamics: implications in diagnosis, treatment, and prognosis in normal pressure hydrocephalus. Arch Neurol. 1975;32:657–64.

    Article  CAS  PubMed  Google Scholar 

  15. Owler BK, Pickard JD. Normal pressure hydrocephalus and cerebral bloodflow: a review. Acta Neurol. Scand. 2001;104:325–42.

    Article  CAS  PubMed  Google Scholar 

  16. Benabid AL, de Rougemont J, Barge M. Cerebral venous pressure,sinus pressure and intracranial pressure (in French).Neurochurgie. 1974;20:623–32,

    CAS  Google Scholar 

  17. Schneck MJ. Normal pressure hydrocephalus. http://emedicine.medscape.com/article/1150924-overview#a6 accessed 0n 6 June 2016.

  18. Damasio AR, Anderson SW. The Frontal lobes In: Clinical Neuropschology Ed. Kenneth M., Heillman and Edward Valenstein. 3rd ed. Oxford University Press. New York. 1993. Pp 439.

    Google Scholar 

  19. Adams RD, Fisher CM, Hakim S, Ojemann RG, Sweet WH. Symptomatic occult hydrocephalus with ‘normal ‘ cerebrospinal fluid pressue. A treatable syndrome. NEJM. 1965;273:117–26.

    Article  CAS  PubMed  Google Scholar 

  20. Price TR, Tucker GJ. Psychiatric and behavioural manifesatations of normal pressure hydrocephalus: a case report and brief review. J Nerv Ment Dis. 1977;164:51–55.

    Article  CAS  PubMed  Google Scholar 

  21. Rice E, Gendelman S. Psychiatric aspects of normal pressure hydrocephalus. J Am Med Ass. 1973;223:409–412,

    Article  CAS  Google Scholar 

  22. Nagaratnam N, Verma S, Nagaratnam K. Psychiatric and behavioural manifestations of normal pressure hydrocephalus. Brit J Clin Pract. 1994;48:122–124.

    CAS  PubMed  Google Scholar 

  23. Bingley T. Mental symptoms in temporal lobe epilepsy mid temporal lobe gliomas: with special reference to laterality of lesion and the relationship between handedness and brainedness. Acta Pychiatr Neurol. 1958 120(suppl,33)1–143.

    CAS  Google Scholar 

  24. Wikkelso C, Anderson H, Blomstrand C, Lindqvist G, Svendsen P. Normal pressure hydrocephalus predictive value of the cerebrospinal fluid test. Acta Neurol Scand. 1986;73:566–573.

    Article  CAS  PubMed  Google Scholar 

Traumatic Brain Injury

  1. Thompson HJ, McCormick WC, Kagan SH. Traumatic brain injury in older adults: Epidemiology, outcomes and future implications. J Am Geriatr Soc. 2006;54(10):1590–1505.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mak CHK, Wong SKH, Wong GK, Ng S, Wang KKW, Lam PK, et al. Traumatic brain injury in the elderly: Is it as bad as we think?. Curr Transl Geriatr Exp Gerontol Rep. 2012;12(3):171–178.

    Article  Google Scholar 

  3. Roozenbeek B, Mass AIR, Menon DK. Changing patterns in the epidemiology of traumatic brain injury. Nat Rev Neurol. 2013;9:231–236.

    Article  PubMed  Google Scholar 

  4. Papa L, Mendes ME, Braga CF. Mild traumatic brain injury among the geriatric population. Curr Transl Geriatr Exp Gerontol Rep. 2012;1(3):135–142.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Senzaki A. Neurobehavioral disability following traumatic brain injury: 7 cases that exhibited neuropsychological impairments and neuropsychitric syndrpomes. Seishin Shinkeigaku Zasshi. 2007;109(3):199–214.

    PubMed  Google Scholar 

  6. Riggio S, Wong M. Neurobehavioural sequelae of traumatic brain injury. Mt Sinai J Med. 2009;76(2):163–72.

    Article  PubMed  Google Scholar 

  7. Simpson JR. DSM-5 .Neurocognitive disorders. J Am Acad Psychiatry Law. 2014;42:2:159–164.

    PubMed  Google Scholar 

  8. World Health Organisation: Dementia: A public health priority. Geneva: World Health Organiation; 2012.

    Google Scholar 

  9. Bullain SS, Corrada MM. Dementia in the oldest old. Continuum (Minneap Minn). 2013;19(2Dementia):457–69.

    Google Scholar 

  10. Wilmot A, Johsson L, Bond J, Prince M, Winbald B. The world –wide economic impact of dementia2010-Alzheimer’s &Dementia. J Alz Assoc . http://aanddjournal.net/article/S1552-5260(12)-7/ful text.

  11. Dementia UK.Update. https://www.alzheimers.org.uk.dementiauk.

  12. Johns H. Testimoy of Harry Johns,President and CEO of the Alzheimer’s Association. Fiscal Year 204 Appropriations for Alzheimer’s –relatd Activities at the US Department of Health.

    Google Scholar 

  13. Speech Notes. The social and economic impact of dementia on ageing people. 6th Annual Australian Ageing Population Summit. Nov 5 2010.

    Google Scholar 

  14. Rising Tide: the impact of dementia on Canadian Society. Executuve Screening. www.al

  15. Kasper JD, Freedman VA, Spillman BC., Wolff JL. The disprportionate impact of dementia on families and unpaid care giving to older adults. Health Affairs. 2015;34(10):1642–1649.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Nuffield Council on Bioethics (NCB). Dementia: EtgicalIssues, Nuffield Council of Bioethics, London UK 2009.

    Google Scholar 

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Authors and Affiliations

  1. The University of Sydney, Westmead Clinical School, Westmead, NSW, Australia

    Nages Nagaratnam & Kujan Nagaratnam

  2. Rehabilitation and Aged Care Service, Blacktown-Mt Druitt Hospital, Mount Druitt, NSW, Australia

    Gary Cheuk

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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Neurodegenerative Disorders. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_71

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