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Monogenic and Polygenic Contributions to Hypertension

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Pediatric Hypertension

Abstract

This chapter provides an overview of the genetics of hypertension, reviewing what is known about rare mendelian forms of hypertension, which can be explained by mutations in single genes, as well as the genetics of primary hypertension. Different approaches that allow discovery of new aspects of the genetics of primary hypertension such as candidate gene approaches, linkage studies, and genome-wide association studies are discussed. It is hoped that this chapter will provide a concise primer for reading the literature in the area of genetics and hypertension. The chapter also provides guidance on patient evaluation and approach.

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Authors and Affiliations

  1. Division of Nephrology, MassGeneral for Children at Massachusetts General Hospital, Harvard Medical School, Department of Pediatrics, Fruit St. 55, Boston, MA, 02114, USA

    Julie R. Ingelfinger

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  1. Julie R. Ingelfinger
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Editors and Affiliations

  1. University of Washington School of Medicine, Department of Pediatrics and Seattle Children’s Hospital Division of Nephrology, Seattle, WA, USA

    Joseph T. Flynn

  2. Division of Nephrology MassGeneral for Children at Massachusetts General Hospital, Harvard Medical School Department of Pediatrics, Boston, MA, USA

    Julie R. Ingelfinger

  3. St. Luke’s Health System, Children’s Nephrology and Hypertension, Boise, ID, USA

    Karen M. Redwine

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  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Harvard Medical School, Fruit St. 55, 02114, Boston, MA, USA

    Julie R. Ingelfinger M.D.

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Ingelfinger, J.R. (2018). Monogenic and Polygenic Contributions to Hypertension. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31107-4_6

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