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Inflammation and Perinatal Brain Injury

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Neonatology

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Abstract

Inflammation is a critical contributor to both normal development and injury outcome in the immature brain. The consequences of immune activation in brain injury will be entirely different depending on context and stage of central nervous system (CNS) maturity. The immature brain can be exposed to inflammation in connection with viral or bacterial infection during pregnancy or as a result of sterile CNS insults such as hypoxia-ischemia and neonatal stroke. Through efficient anti-inflammatory and reparative processes, inflammation may resolve without any harmful effects on the brain. Alternatively, inflammation contributes to injury or enhances CNS vulnerability. Acute inflammation can also be shifted to a chronic inflammatory state and/or adversely affect brain development resulting in neurologic disease in children or adults.

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Authors and Affiliations

  1. Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden

    Henrik Hagberg

  2. Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, UK

    Henrik Hagberg

  3. Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Carina Mallard

  4. Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Karin Sävman

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  1. Henrik Hagberg
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  2. Carina Mallard
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  3. Karin Sävman
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Correspondence to Henrik Hagberg .

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Editors and Affiliations

  1. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Giuseppe Buonocore

  2. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women’s Hospital Neonatal Unit, Liverpool, UK

    Michael Weindling

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Hagberg, H., Mallard, C., Sävman, K. (2018). Inflammation and Perinatal Brain Injury. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-29489-6_265

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