Synonyms
Definition
Is a locally aggressive fibrolipomatous, hemosiderin-rich neoplasia
Clinical Features
Incidence
Rare soft tissue neoplasm
Age
Occur mainly in the fifth and sixth decade of life (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).
Sex
Affects predominantly women (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).
Site
Most commonly affected sites are the dorsum of the foot and the ankle region. Less frequently effected regions include the upper limbs, hands, and the head/neck region (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).
Treatment
Complete surgical excision is the treatment of choice.
Outcome
The local recurrence rate is 30–50% if initially incompletely excised. Complete excision is generally curative (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).
Macroscopy
HFLT is an ill-defined yellowish-brown tumor with a tumor size ranging from 1 to 20 cm...
References and Further Reading
Antonescu, C. R., Zhang, L., Nielsen, G. P., et al. (2011). Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. Genes, Chromosomes and Cancer, 50, 757–764. PMID: 21717526.
Browne, T. J., & Fletcher, C. D. (2006). Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): Analysis of 13 new cases in support of a distinct entity. Histopathology, 48, 453–461. PMID: 16487368.
Elco, C. P., Mariño-EnrÃquez, A., Abraham, J. A., et al. (2010). Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: Report of a case providing further evidence for a pathogenetic link. The American Journal of Surgical Pathology, 34, 1723–1727. PMID: 20871391.
Hallor, K. H., Sciot, R., Staaf, J., et al. (2009). Two genetic pathways, t(1;10) and amplification of 3p11–12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions. The Journal of Pathology, 217, 716–727. PMID: 19199331.
Marshall-Taylor, C., & Fanburg-Smith, J. C. (2000). Hemosiderotic fibrohistiocytic lipomatous lesion: Ten cases of a previously undescribed fatty lesion of the foot/ankle. Modern Pathology, 13, 1192–1199. PMID: 11106076.
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Liegl-Atzwanger, B. (2020). Hemosiderotic Fibrolipomatous Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5397-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5397-1
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