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Intensive Care of the Child After Liver Transplantation

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Solid Organ Transplantation in Infants and Children

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

The intensive care of the pediatric patient following solid organ transplant actually begins prior to surgery with a discussion of the patient among all the key stakeholders. Giving families tours of the pediatric intensive care unit, building a dedicated nursing team, and having resources available are essential. Following surgery, attention to detail is the key component during the transition from the operating room to the intensive care unit. This review covers handoff from the operating room to the intensive care unit, postoperative stabilization, and management including respiratory management, fluids, electrolytes and acid/base status, cardiovascular management, assessment of graft function, and neurologic management. Other topics specific to the transplant include immunosuppression, anticoagulation, infection prevention, and nutrition. It is important to monitor for complications following solid organ transplant; failure to rescue starts with a failure to recognize. Common complications following transplantation are discussed including primary nonfunction, vascular complications, biliary complications, rejection, and infection.

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References

  • de Haan K, Groeneveld AB, de Geus HR et al (2014) Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis. Crit Care 18:660

    Article  PubMed  PubMed Central  Google Scholar 

  • Desai CS, Sharma S, Gruessner A et al (2015) Effect of small donor weight and donor-recipient weight ratio on the outcome of liver transplantation in children. Pediatr Transplant 19:366–370

    Article  PubMed  Google Scholar 

  • Feldman AG, Sundaram SS, Beaty BL et al (2017) Hospitalizations for respiratory syncytial virus and vaccine-preventable infections in the first 2 years after pediatric liver transplant. J Pediatr 182:232–238.e1. epub ahead of press

    Article  PubMed  Google Scholar 

  • Fernandez D, El-Azzabi TI, Jain V et al (2010) Neurologic problems after pediatric liver transplantation and combined liver and bowel transplantations: a single tertiary centre experience. Transplantation 90:319–324

    Article  PubMed  Google Scholar 

  • Fullington NM, Cauley RP, Potanos KM et al (2015) Immediate extubation after pediatric liver transplantation: a single-center experience. Liver Transpl 21:57–62

    Article  PubMed  Google Scholar 

  • Ganschow R, Nolkemper D, Helmke K et al (2000) Intensive care management after pediatric liver transplantation: a single-center experience. Pediatr Transplant 4:273–279

    Article  CAS  PubMed  Google Scholar 

  • Ghosh PS, Hupertz V, Ghosh D (2012) Neurological complications following pediatric liver transplant. J Pediatr Gastroenterol Nutr 54:540–546

    Article  PubMed  Google Scholar 

  • Gungor S, Kilic B, Arslan M et al (2017) Early and late neurological complications of liver transplantation in pediatric patients. Pediatr Transplant 21:e12872

    Article  Google Scholar 

  • Hackl C, Schlitt HJ, Melter M et al (2015) Current developments in pediatric liver transplantation. World J Hepatol 7:1509–1520

    Article  PubMed  PubMed Central  Google Scholar 

  • Hong SH, Kwak JA, Jeon JY et al (2013) Prediction of early allograft dysfunction using serum phosphorus level in living donor liver transplantation. Transpl Int 26:402–410

    Article  CAS  PubMed  Google Scholar 

  • Jamieson LH, Arys B, Low G et al (2014) Doppler ultrasound velocities and resistive indexes immediately after pediatric liver transplantation: normal ranges and predictors of failure. AJR Am J Roentgenol 203:W110–W116

    Article  PubMed  Google Scholar 

  • Kerkar N, Danialifar T (2014) Changing definitions of successful outcomes in pediatric liver transplantation. Curr Opin Organ Transplant 19:480–485

    Article  PubMed  Google Scholar 

  • Kukreti V, Daoud H, Bola SS et al (2014) Early critical care course in children after liver transplant. Crit Care Res Pract 2014:725748

    PubMed  PubMed Central  Google Scholar 

  • Lee YJ, Yum M-S, Kim E-H et al (2014) Risk factors for neurological complications and their correlation with survival following pediatric liver transplantation. Pediatr Transplant 18:177–184

    Article  PubMed  Google Scholar 

  • Legarda M, Gordon G, Lloyd C et al (2013) Vitamin D deficiency and insufficiency after pediatric liver transplantation. Pediatr Transplant 17:631–637

    CAS  PubMed  Google Scholar 

  • Manczur TI, Greenough A, Rafferty GF et al (2002) Diaphragmatic dysfunction after pediatric orthotopic liver transplantation. Transplantation 73:228–232

    Article  PubMed  Google Scholar 

  • Matloff RG, Arnon R, Saland JM (2012) The kidney in pediatric liver transplantation: an updated perspective. Pediatr Transplant 16:818–828

    Article  CAS  PubMed  Google Scholar 

  • Miloh T (2014) Medical management of children after liver transplantation. Curr Opin Organ Transplant 19:474–479

    Google Scholar 

  • Miloh T, Barton A, Wheeler J et al (2017) Immunosuppression in pediatric liver transplant recipients: unique aspects. Liver Transpl 23:244–256

    Article  PubMed  Google Scholar 

  • Murase K, Chihara Y, Takahashi K et al (2012) Use of noninvasive ventilation for pediatric patients after liver transplantation: decrease in the need for reintubation. Liver Transpl 18:1217–1225

    Article  PubMed  Google Scholar 

  • Narkewicz MR, Green M, Dunn S et al (2013) Decreasing incidence of symptomatic Epstein-Barr virus disease and post-transplant lymphoproliferative disorder in pediatric liver transplant recipients: report of the studies of pediatric liver transplantation experience. Liver Transpl 19:730–740

    Article  PubMed  PubMed Central  Google Scholar 

  • Santos J, Young P, Barjaktarevic I et al (2014) The successful use of inhaled nitric oxide in the management of severe hepatopulmonary syndrome after orthotopic liver transplantation. Case Reports Hepatol 2014:415109

    Article  PubMed  PubMed Central  Google Scholar 

  • Schiller O, Avitzur Y, Kadmon G et al (2011) Nitric oxide for post-liver-transplantation hypoxemia in pediatric hepatopulmonary syndrome: case report and review. Pediatr Transplant 15:E130–E134

    Article  PubMed  Google Scholar 

  • Shepherd RW, Turmelle Y, Nadler M et al (2008) Risk factors for rejection and infection in pediatric liver transplantation. Am J Transplant 8:396–403

    Article  CAS  PubMed  Google Scholar 

  • Soriano-Lopez DP, Alcantar-Fierros JM, Hernandez-Plata JA et al (2016) A scheduled program of molecular screening for Epstein-Barr virus decreases the incidence of post-transplantation lymphoproliferative disease in pediatric liver transplantation. Transplant Proc 48:654–657

    Article  CAS  PubMed  Google Scholar 

  • Spada M, Riva S, Maggiore G et al (2009) Pediatric liver transplantation. World J Gastroenterol 15:648–674

    Article  PubMed  PubMed Central  Google Scholar 

  • Tannuri U, Tannuri AC (2014) Postoperative care in pediatric liver transplantation. Clinics 69(S1):42–46

    Article  PubMed  PubMed Central  Google Scholar 

  • Verma A, Palaniswamy K, Cremonini G et al (2017) Late cytomegalovirus infection in children: high incidence of allograft rejection and hepatitis in donor negative and seropositive liver transplant recipients. Pediatr Transplant 21:e12879

    Article  Google Scholar 

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Correspondence to Ranna A. Rozenfeld .

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Rozenfeld, R.A., Harris, Z.L. (2018). Intensive Care of the Child After Liver Transplantation. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07284-5_44

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  • DOI: https://doi.org/10.1007/978-3-319-07284-5_44

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07283-8

  • Online ISBN: 978-3-319-07284-5

  • eBook Packages: MedicineReference Module Medicine

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