Synonyms
Inflammatory myofibrohistiocytic proliferation; Inflammatory pseudotumor; Plasma cell granuloma; Pseudosarcomatous myofibroblastic tumor
Definition
Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts accompanied by a mixed inflammatory infiltrate.
Clinical Features
Incidence
IMT is a relatively rare tumor in the genitourinary system.
Age
It may occur at all ages, including in children. The mean age at diagnosis is 50 years.
Sex
It involves more frequently male subjects.
Site
Genitourinary IMT arise more frequently in the bladder, but cases have been reported also in the kidneys, prostate, spermatic cord, and testis.
Treatment
In the bladder, most cases are treated with transurethral resection. Some patients have undergone partial cystectomy.
Outcome
IMT is a locally aggressive neoplasm, with tendency to local recurrence, and rare incidence of metastasis.
Macroscopy
Grossly, IMT appears as a circumscribed solitary or multinodular mass with a white to...
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Harik, L. R., Merino, C., Coindre, J. M., et al. (2006). Pseudosarcomatous myofibroblastic proliferations of the bladder: A clinicopathologic study of 42 cases. The American Journal of Surgical Pathology, 30, 787–794.
Jebastin, J. A. S., Smith, S. C., Perry, K. D., Gupta, N. S., Alanee, S., Carskadon, S., Chitale, D. A., Palanisamy, N., & Williamson, S. R. (2018). Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements. Histopathology, 73, 321–326.
Kapusta, L., Weiss, M., Ramsay, J., et al. (2003). Inflammatory myofibroblastic tumors of the kidney: A clinicopathologic and immunohistochemical study of 12 cases. The American Journal of Surgical Pathology, 27, 658–666.
Montgomery, E. A., Shuster, D. D., Burkart, A. L., Esteban, J. M., Sgrignoli, A., Elwood, L., Vaughn, D. J., Griffin, C. A., & Epstein, J. I. (2006). Inflammatory myofibroblastic tumors of the urinary tract: A clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma. The American Journal of Surgical Pathology, 30, 1502–1512.
Tsuzuki, T., Magi-Galluzzi, C., & Epstein, J. I. (2004). ALK-1 expression in inflammatory myofibroblastic tumor of the urinary bladder. The American Journal of Surgical Pathology, 28, 1609–1614.
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Franchi, A. (2020). Inflammatory Myofibroblastic Tumor. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4832
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4832
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Publisher Name: Springer, Cham
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