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Vaccine Therapy and Immunotherapy for Pancreatic Cancer

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Pancreatic Cancer

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Abstract

Recent advances in the tumor immunology field of research have enriched our knowledge of how tumor cells initially evade immune surveillance and how existing tumors actively suppress immune recognition of their progression. Based on these advances, strategies for immunotherapy have been developed to enhance antitumor immunity and to target the mechanisms underlying tumor evasion and immune tolerance. These immunotherapy strategies have been employed in the design of novel treatments for pancreatic cancer and are being tested in preclinical studies and human clinical trials. Evidence of immune activation has been demonstrated in a number of these studies and, in some cases, correlated with clinical responses. However, a number of challenges must be addressed before the true potential of immune-based therapies can be determined. Consequently, future studies need to focus on identifying new pancreatic cancer-associated antigens and on identifying and targeting the immune checkpoints that inhibit effective immune cell activation. In addition, the development of these new therapies will require designing clinical trials that efficiently assess combinations of biologics that target multiple immune pathways and incorporate validated predictors of immune response. Finally, demonstrating the success of these new therapies will likely require establishing new criteria to evaluate clinical responses that are associated with immune-mediated mechanisms of tumor control.

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Authors and Affiliations

  1. The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Lei Zheng & Elizabeth M. Jaffee

Authors
  1. Lei Zheng
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  2. Elizabeth M. Jaffee
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Corresponding author

Correspondence to Lei Zheng .

Editor information

Editors and Affiliations

  1. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    John P. Neoptolemos

  2. Division of Research Department of Surgery and Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Raul Urrutia

  3. Division of Medical Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA

    James L. Abbruzzese

  4. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    Markus W. Büchler

Section Editor information

  1. Division of Surgery and Oncology, University of Liverpool, Daulby Street, Liverpool, UK

    John Neoptolemos

  2. Mayo Clinic Cancer Center, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA

    Raul A. Urrutia

  3. Duke University Medical Center, Durham, NC, USA

    James L. Abbruzzese

  4. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Markus W. Büchler

  5. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Thilo Hackert

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Zheng, L., Jaffee, E.M. (2018). Vaccine Therapy and Immunotherapy for Pancreatic Cancer. In: Neoptolemos, J., Urrutia, R., Abbruzzese, J., Büchler, M. (eds) Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7193-0_53

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